Responsabile dell'U.O.
Cognome e Nome
Uberti Daniela Letizia
Qualifica
PO
Dipartimento
Molecular and Translational Medicine, University of Brescia
Settore scientifico disciplinare
BIO-14 FARMACOLOGIA
daniela.uberti@unibs.it
Telefono
0303717519
Personale strutturato
Cognome e Nome
Bonini Sara
Qualifica
RTDB
Dipartimento
Molecular and Translational Medicine
Ente di appartenenza
University of Brescia
Cognome e Nome
Gianoncelli Alessandra
Qualifica
PA
Dipartimento
Molecular and Translational Medicine
Ente di appartenenza
University of Brescia
Cognome e Nome
Peron Gregorio
Qualifica
RTDB
Dipartimento
Molecular and Translational Medicine
Ente di appartenenza
University of Brescia
Cognome e Nome
Abate Giulia
Qualifica
RTDA
Dipartimento
Molecular and Translational Medicine
Ente di appartenenza
University of Brescia
Cognome e Nome
Mastinu Andrea
Qualifica
RTDA
Dipartimento
Molecular and Translational Medicine
Ente di appartenenza
University of Brescia
Personale non strutturato
Cognome e Nome
Pucci Mariachiara
Qualifica
Post-doc
Dipartimento
Molecular and Translational Medicine
Ente di appartenenza
Molecular and Translational Medicine
Cognome e Nome
Tirelli Emanuela
Qualifica
Ph.D student
Dipartimento
Molecular and Translational Medicine
Ente di appartenenza
Molecular and Translational Medicine
Linee di ricerca
- Pathophysiology of neurodegenerative diseases and psychiatric disorders. - identification and validation of early biomarkers for the timely diagnosis of Alzheimer’s disease
- identification and validation of biomarkers for monitoring L-DOPA therapy in Parkinson's disease
- Electrochemical sensors for biomarker detection - Proteomics and redox-proteomics studies in neurodegenerative diseases - Study of redox homeostasis regulation in aging brain processes - study of Nutraceuticals and botanicals in term of phytochemical characterization, biological activity and therapeutic effects
Tecnologie in uso dall'UO
- 1.Proteomics and redox-proteomics
- 2.2D-DIGE
- 3.Antioxidant enzyme activity assay
- 4.Confocal microscopy
- 5.EthoVision XT software (Noldus) for mice behavioral test battery
- 6.HPLC
- 7.Mass spectrometry
- 8.Computational methods for drug discovery
Strumentazione
Denominazione
Syngene G:BOX Chemi XX6/XX9
HPLC-DAD
MALDI-MS
SHIMADZU HPLC-UV-VIS
Struttura ove la strumentazione è allocata
Section of Pharmacology
Section of Pharmacology
Proteomic platform
Proteomic platform
Responsabile
Prof. Daniela Uberti
Dr. Andrea Mastinu
Prof. Gianoncelli
Prof. Gianoncelli
Pubblicazioni
- 1.The Bright Side of Psychedelics: Latest Advances and Challenges in Neuropharmacology. Mastinu A, Anyanwu M, Carone M, Abate G, Bonini SA, Peron G, Tirelli E, Pucci M, Ribaudo G, Oselladore E, Premoli M, Gianoncelli A, Uberti DL, Memo M.Int J Mol Sci. 2023 Jan 10;24(2):1329. doi: 10.3390/ijms24021329
- 2.Different Seasonal Collections of Ficus carica L. Leaves Diversely Modulate Lipid Metabolism and Adipogenesis in 3T3-L1 Adipocytes. Pucci M, Mandrone M, Chiocchio I, Sweeney EM, Tirelli E, Uberti D, Memo M, Poli F, Mastinu A, Abate G.Nutrients. 2022 Jul 10;14(14):2833. doi: 10.3390/nu14142833
- 3.Methylglyoxal affects cognitive behaviour and modulates RAGE and Presenilin-1 expression in hippocampus of aged mice. Pucci M, Aria F, Premoli M, Maccarinelli G, Mastinu A, Bonini S, Memo M, Uberti D, Abate G.Food Chem Toxicol. 2021 Dec;158:112608. doi: 10.1016/j.fct.2021.112608. Epub 2021 Oct 14
- 4.A Conformation Variant of p53 Combined with Machine Learning Identifies Alzheimer Disease in Preclinical and Prodromal Stages. Abate G, Vezzoli M, Polito L, Guaita A, Albani D, Marizzoni M, Garrafa E, Marengoni A, Forloni G, Frisoni GB, Cummings JL, Memo M, Uberti D.J Pers Med. 2020 Dec 26;11(1):14. doi: 10.3390/jpm11010014
- 5.Mitochondria and cellular redox state on the route from ageing to Alzheimer's disease. Abate G, Vezzoli M, Sandri M, Rungratanawanich W, Memo M, Uberti D.Mech Ageing Dev. 2020 Dec;192:111385. doi: 10.1016/j.mad.2020.111385. Epub 2020 Oct 28.
- 6.A telescope GWAS analysis strategy, based on SNPs-genes-pathways ensamble and on multivariate algorithms, to characterize late onset Alzheimer's disease. Squillario M, Abate G, Tomasi F, Tozzo V, Barla A, Uberti D; Alzheimer’s Disease Neuroimaging Initiative.Sci Rep. 2020 Jul 21;10(1):12063. doi: 10.1038/s41598-020-67699-8.
- 7.Gamma-oryzanol Prevents LPS-induced Brain Inflammation and Cognitive Impairment in Adult Mice. Mastinu A, Bonini SA, Rungratanawanich W, Aria F, Marziano M, Maccarinelli G, Abate G, Premoli M, Memo M, Uberti D.Nutrients. 2019 Mar 29;11(4):728. doi: 10.3390/nu11040728
- 8.γ-Oryzanol Improves Cognitive Function and Modulates Hippocampal Proteome in Mice. 4 Rungratanawanich W, Cenini G, Mastinu A, Sylvester M, Wilkening A, Abate G, Bonini SA, Aria F, Marziano M, Maccarinelli G, Memo M, Voos W, Uberti D
- 9.Monitoring Caco-2 to enterocyte-like cells differentiation by means of electric impedance analysis on printed sensors. Marziano M, Tonello S, Cantù E, Abate G, Vezzoli M, Rungratanawanich W, Serpelloni M, Lopomo NF, Memo M, Sardini E, Uberti D.Biochim Biophys Acta Gen Subj. 2019 May;1863(5):893-902. doi: 10.1016/j.bbagen.2019.02.008.
- 10.Protein nitration profile of CD3+ lymphocytes from Alzheimer disease patients: Novel hints on immunosenescence and biomarker detection. Tramutola A, Abate G, Lanzillotta C, Triani F, Barone E, Iavarone F, Vincenzoni F, Castagnola M, Marziano M, Memo M, Garrafa E, Butterfield DA, Perluigi M, Di Domenico F, Uberti D.Free Radic Biol Med. 2018 Dec;129:430-439. doi: 10.1016/j.freeradbiomed.2018.10.414. Epub 2018
Dottorati di ricerca
Componente UO
Uberti Daniela
Bonini Sara
Gianoncelli Alessandra
Dottorato di ricerca
Biochemical Science and Translational Medicine
Biochemical Science and Translational Medicine
Precision Medicine
Coordinatore
Prof. Mariacristina Missale
Prof. Mariacristina Missale
Prof. Marco Presta
Sede
Brescia
Brescia
Brescia