Saggio-lab projects -Gene therapy vectors In the years we have been dealing with different viruses, including AAV, lentivirus, adenovirus and humanized phages. We use viral vectors for gene correction and disease modeling. Along with this we have been studying the properties of these viral vectors to understand their biology and possibly to design their amelioration. -Telomeres and lamins in natural and pathological aging We have characterized a new telomeric gene interacting with lamins named AKTIP. AKTIP properties put it at the crossroad of central aspects of human metabolism including DNA replication, nuclear architecture, telomeropathies, laminopathies and cancer. We’re studying the implication of this gene in the different metabolic pathways by in tube and in vivo analyses. Collaborative projects -Stem cell related bone disease We collaborate with P. Bianco lab (Sapienza Univeristy) in a project aiming at modeling, studying and correcting the bone genetic disease fibrous dysplasia. -Neonatal diabetes We collaborate with F. Barbetti lab (TorVergata University) for the development of a therapeutic approach for neonatal diabetes associated with dominant insulin gene mutations by means of allele specific silencing.