Responsabile dell'U.O.
Cognome e Nome
Rossi luigia
Qualifica
PO
Dipartimento
Scienze Biomolecolari (DISB)
Settore scientifico disciplinare
BIO/10
luigia.rossi@uniurb.it
Telefono
0722305201
Personale strutturato
Cognome e Nome
ANTONELLI ANTONELLA
Qualifica
Technician
Dipartimento
Scienze Biomolecolari (DISB)
Ente di appartenenza
Università degli Studi di Urbino “Carlo Bo”
Cognome e Nome
CASABIANCA ANNA
Qualifica
Ricercatore
Dipartimento
Scienze Biomolecolari (DISB)
Ente di appartenenza
Università degli Studi di Urbino “Carlo Bo”
Cognome e Nome
FANELLI MIRCO
Qualifica
PO
Dipartimento
Scienze Biomolecolari (DISB)
Ente di appartenenza
Università degli Studi di Urbino “Carlo Bo”
Personale non strutturato
Linee di ricerca
1. Red blood cells as a delivery system for contrasting agents. The advantage of the proposed strategy lies on the possibility to prevent premature degradation, inactivation or elimination of contrasting agents leading to a longer detection and observation times for imaging purposes.
2. Erythrocytes-mediated delivery of glucocorticoid analogue in clinical studies. Autologous erythrocytes loaded with glucocorticoid analogues will be administered to patients with inflammatory diseases. The aim is to improve the pharmacokinetic properties of the drugs in order to obtain low, constant and prolonged concentrations of glucocorticoids in circulation.
3. Drug delivery to macrophages by erythrocytes. Drugs, including nucleotide analogues, will be selectively administered to macrophages by erythrocytes. Special attention will be focused to the modulation of drug intracellular compartimentation by using the endosomolytic protein listeriolysin O.
Tecnologie in uso dall'UO
- Drug delivery and targeting by loaded erythrocytes
- Molecular biotechnology
- RT-PCR technology
- Cellular culture