Presta Marco

Responsabile dell'U.O.

Cognome e Nome

Presta Marco

Qualifica

PO

Dipartimento

Molecular and Translational Medicine, University of Brescia

Settore scientifico disciplinare

MED04 “Patologia Generale”

E-mail

marco.presta@unibs.it

Telefono

+39-030-3717310

Personale strutturato

Cognome e Nome

Belleri Mirella

Qualifica

Technician

Dipartimento

Molecular and Translational Medicine

Ente di appartenenza

University of Brescia

Cognome e Nome

Arianna Giacomini

Qualifica

PA

Dipartimento

Molecular and Translational Medicine

Ente di appartenenza

University of Brescia

Cognome e Nome

Tiberio Laura

Qualifica

Ricercatore

Dipartimento

Molecular and Translational Medicine

Ente di appartenenza

University of Brescia

Personale non strutturato

Cognome e Nome

Capoferri Davide

Qualifica

Post-doc

Dipartimento

Molecular and Translational Medicine

Ente di appartenenza

University of Brescia

Cognome e Nome

Guerra Jessica

Qualifica

Post-doc

Dipartimento

Molecular and Translational Medicine

Ente di appartenenza

University of Brescia

Cognome e Nome

Mignani Luca

Qualifica

Post-doc

Dipartimento

Molecular and Translational Medicine

Ente di appartenenza

University of Brescia

Linee di ricerca

• Role of angiogenesis in tumor growth and characterization of novel anti-angiogenic compounds • Development of novel in vitro and in vivo experimental models for the characterization of pro- and anti-angiogenic compounds. • Study of the signal transduction pathways activated by the interaction of the angiogenic growth factor FGF2 with its tyrosine-kinase FGFR receptors • Zebrafish in experimental oncology and hereditary human diseases • Role of sphingolipid metabolism in tumor growth, angiogenesis, and metastasis

Tecnologie in uso dall'UO

  1. 1.
    Recombinant proteins
  2. 2.
    Angiogenesis assays
  3. 3.
    Gene expression analysis
  4. 4.
    Zebrafish morpholinos
  5. 5.
    Time-lapse microscopy
  6. 6.
    Protein mutagenesis
  7. 7.
    Retro and lentivirus cell transfection
  8. 8.
    Gene KO by CRISPR/Cas9 in zebrafish and cell lines
  9. 9.
    Tumor grafts in mice, zebrafish and chick embryos
  10. 10.
    Microscopy

Strumentazione

Denominazione

Inverted time-lapse fluorescence microscope

Struttura ove la strumentazione è allocata

Unit of Experimental Oncology and Immunology, Department of Molecular and Translational Medicine

Responsabile

Marco Presta

Pubblicazioni

  1. 1.
    L. Mignani, J. Guerra, M. Corli, D. Capoferri, M. Presta, Zebra-Sphinx: Modeling Sphingolipidoses in Zebrafish, Int J Mol Sci, 24 (2023) 4747.
  2. 2.
    D. Coltrini, A.M.K. Chandran, M. Belleri, P.L. Poliani, M. Cominelli, F. Pagani, M. Capra, S. Calza, S. Prioni, L. Mauri, A. Prinetti, J.K. Kofler, M.L. Escolar, M. Presta, beta-Galactosylceramidase Deficiency Causes Upregulation of Long Pentraxin-3 in the Central Nervous System of Krabbe Patients and Twitcher Mice, Int J Mol Sci, 23 (2022), 9436.
  3. 3.
    M. Belleri, P. Chiodelli, M. Corli, M. Capra, M. Presta, Oncosuppressive and oncogenic activity of the sphingolipid-metabolizing enzyme beta-galactosylceramidase, Biochim Biophys Acta Rev Cancer, 1877 (2022) 188675.
  4. 4.
    Schioppa T, Nguyen HO, Salvi V, Maugeri N, Facchinetti F, Villetti G, Civelli M, Gaudenzi C, Passari M, Sozio F, Barbazza I, Tamassia N, Cassatella MA, Del Prete A, Bosisio D, Tiberio L. The PDE4 Inhibitor Tanimilast Restrains the Tissue-Damaging Properties of Human Neutrophils. Int J Mol Sci. 23 (2022) 4982.
  5. 5.
    R. Ronca, S. Taranto, M. Corsini, C. Tobia, C. Ravelli, S. Rezzola, M. Belleri, F. De Cillis, A. Cattaneo, M. Presta, A. Giacomini, Pentraxin 3 Inhibits the Angiogenic Potential of Multiple Myeloma Cells, Cancers (Basel), 13 (2021) 2255
  6. 6.
    A. Giacomini, E. Grillo, S. Rezzola, D. Ribatti, M. Rusnati, R. Ronca, M. Presta, The FGF/FGFR system in the physiopathology of the prostate gland, Physiol Rev, 101 (2021) 569-610.
  7. 7.
    R. Ronca, G.C. Ghedini, F. Maccarinelli, A. Sacco, S.L. Locatelli, E. Foglio, S. Taranto, E. Grillo, S. Matarazzo, R. Castelli, G. Paganini, V. Desantis, N. Cattane, A. Cattaneo, M. Mor, C. Carlo-Stella, A. Belotti, A.M. Roccaro, M. Presta, A. Giacomini, FGF Trapping Inhibits Multiple Myeloma Growth through c-Myc Degradation-Induced Mitochondrial Oxidative Stress, Cancer Res, (2020) 2340-2354.
  8. 8.
    M. Belleri, G. Paganini, D. Coltrini, R. Ronca, D. Zizioli, M. Corsini, A. Barbieri, E. Grillo, S. Calza, R. Bresciani, E. Maiorano, M.G. Mastropasqua, T. Annese, A. Giacomini, D. Ribatti, J. Casas, T. Levade, G. Fabrias, M. Presta, beta-Galactosylceramidase Promotes Melanoma Growth via Modulation of Ceramide Metabolism, Cancer Res, 80 (2020) 5011-5023.
  9. 9.
    M. Belleri, D. Coltrini, M. Righi, C. Ravelli, S. Taranto, P. Chiodelli, S. Mitola, M. Presta, A. Giacomini, beta-Galactosylceramidase Deficiency Causes Bone Marrow Vascular Defects in an Animal Model of Krabbe Disease, Int J Mol Sci, 21 (2019) 251.
  10. 10.
    Tiberio L, Del Prete A, Schioppa T, Sozio F, Bosisio D, Sozzani S. Chemokine and chemotactic signals in dendritic cell migration. Cell Mol Immunol. 15 (2018) 346-352.

Dottorandi di ricerca

Componente UO

Presta Marco
Giacomini Arianna

Dottorato di ricerca

Precision Medicine
Precision Medicine

Coordinatore

Presta Marco
Presta Marco

Sede

Brescia
Brescia