Nastruzzi Claudio


Responsabile dell'U.O.

Cognome e Nome

Nastruzzi Claudio

Qualifica

PA

Dipartimento

Scienze Chimiche e Farmaceutiche e Agrarie

Settore scientifico disciplinare

Chim 09

E-mail

nas@unife.it

Telefono

Personale strutturato

Cognome e Nome

Cortesi Rita

Qualifica

PA

Dipartimento

Scienze Chimiche e Farmaceutiche e Agrarie

Ente di appartenenza

Università di Ferrara

Cognome e Nome

Esposito Elisabetta

Qualifica

PA

Dipartimento

Scienze Chimiche e Farmaceutiche e Agrarie

Ente di appartenenza

Università di Ferrara

Personale non strutturato

Cognome e Nome

Sguizzato Maddalena

Qualifica

RTDA

Dipartimento

Dipartimento di Scienze chimiche, farmaceutiche ed agrarie

Ente di appartenenza

Università di Ferrara

Linee di ricerca

Nano- and Micro-systems for drug delivery Controlled release of biological response modifiers. Production and characterization of particulate delivery systems: liposomes, cubosomes, microspheres for gene therapy Conduits for nerve repair Development and optimization of different bioencapsulation methods for the production of conduits for nerve repair. Study of new materials for cell encapsulation and identification of new processes allowing the use of these materials under mild and biocompatible conditions Lab-on-a-chip Prodution and characterization of nano- and microparticellar system for biopharmaceutical applications on a Lab-on-a-chip based microelectronic technology" Phytonutrients Design, production and characterization of microparticles made of enteric resistant polymers to prevent phytonutrients release to the stomach and to the upper small intestine Lipospheres Lipidic microspheres, lipospheres (LS) as new type of fat-based encapsulation system developed for drug delivery of bioactive compounds (especially lipophilic compounds). LS combine the advantages of polymeric nanoparticles, fat emulsions and liposomes avoiding some of their disadvantages, such as cytotoxic effects after phagocytosis, toxic effects of organic residues after the production of polymers, lack of large industrial scale production Multifunctional microcapsules for islets entrapment We introduced a new approach for the integrated immunoprotection of transplanted islets, irrespective of the islet origin and maturation level. In this approach, the ‘‘islet compartment’’ benefit from a ‘‘chemical/pharmacologic agent compartment’’ constituted of a sustained release formulation able to deliver the included biological response modifiers for long periods of time Liposomes, micelles and microemulsions as delivery systems for biological response modifiers Design and performance of specialized delivery systems (SDSs) such as liposomes, micellar solutions and microemulsions Prototyping Rapid prototyping technology for the quick production of three-dimensional objects without expensive tooling techniques during the product development stage

Tecnologie in uso dall'UO

  1. 1.
    Nano- and Micro-systems for drug delivery
  2. 2.
    Lab-on-a-chip
  3. 3.
    Lipospheres
  4. 4.
    Liposomes, micelles and microemulsions as delivery systems
  5. 5.
    Prototyping
  6. 6.
    Conduits for nerve repair
  7. 7.
    Phytonutrients
  8. 8.
    Multifunctional microcapsules for islets entrapment
  9. 9.
    Gelatin devices

Strumentazione

Denominazione

HPLC
Spray Drier
Vibrating encapsulator
DSC
Laser granulometer
Zetasizer Nano 90S
Rheometer

Struttura ove la strumentazione è allocata

Dip. Scienze Chimiche e Farmaceutiche e Agr.
Dip. Scienze Chimiche e Farmaceutiche e Agr.
Dip. Scienze Chimiche e Farmaceutiche e Agr.
Dip. Scienze Chimiche e Farmaceutiche e Agr.
Dip. Scienze Chimiche e Farmaceutiche e Agr.
Dip. Scienze Chimiche e Farmaceutiche e Agr.
Dip. Scienze Chimiche e Farmaceutiche e Agr.

Responsabile

Claudio Nastruzzi, Rita Cortesi
Claudio Nastruzzi, Rita Cortesi
Claudio Nastruzzi,
Claudio Nastruzzi
Claudio Nastruzzi
Rita Cortesi
Claudio Nastruzzi

Pubblicazioni

  1. 1.
    1. Esposito E, Nastruzzi C, Sguizzato M, Cortesi R. Nanomedicines to Treat Skin Pathologies with Natural Molecules. Curr Pharm Des. 2019;25(21):2323-2337. doi: 10.2174/1381612825666190709210703.
  2. 2.
    2. Esposito E, Sguizzato M, Drechsler M, Mariani P, Carducci F, Nastruzzi C, Valacchi G, Cortesi R. Lipid nanostructures for antioxidant delivery: a comparative preformulation study. Beilstein J Nanotechnol. 2019 Aug 29;10:1789-1801. doi: 10.3762/bjnano.10.174. eCollection 2019.
  3. 3.
    3. Pitingolo G, Taly V, Nastruzzi C. Coins in microfluidics: From mere scale objects to font of inspiration for microchannel circuits. Biomicrofluidics. 2019 Apr 9;13(2):024106. doi: 10.1063/1.5086535. eCollection 2019 Mar.
  4. 4.
    4. Pitingolo G, Riaud A, Nastruzzi C, Taly V. Gelatin-Coated Microfluidic Channels for 3D Microtissue Formation: On-Chip Production and Characterization. Micromachines (Basel). 2019 Apr 19;10(4). pii: E265. doi: 10.3390/mi10040265.
  5. 5.
    5. Esposito E, Pecorelli A, Sguizzato M, Drechsler M, Mariani P, Carducci F, Cervellati F, Nastruzzi C, Cortesi R, Valacchi G. Production and Characterization of Nanoparticle Based Hyaluronate Gel Containing Retinyl Palmitate for Wound Healing. Curr Drug Deliv. 2018;15(8):1172-1182. doi: 10.2174/1567201815666180518123926.
  6. 6.
    6. Mancuso F, Calvitti M, Milardi D, Grande G, Falabella G, Arato I, Giovagnoli S, Vincenzoni F, Mancini F, Nastruzzi C, Bodo M, Baroni T, Castagnola M, Marana R, Pontecorvi A, Calafiore R, Luca G. Testosterone and FSH modulate Sertoli cell extracellular secretion: Proteomic analysis. Mol Cell Endocrinol. 2018 Nov 15;476:1-7. doi: 10.1016/j.mce.2018.04.001. Epub 2018 Apr 25.
  7. 7.
    7. Esposito E, Sguizzato M, Bories C, Nastruzzi C, Cortesi R. Production and Characterization of a Clotrimazole Liposphere Gel for Candidiasis Treatment. Polymers (Basel). 2018 Feb 8;10(2). pii: E160. doi: 10.3390/polym10020160.
  8. 8.
    8. Mancuso F, Arato I, Lilli C, Bellucci C, Bodo M, Calvitti M, Aglietti MC, dell'Omo M, Nastruzzi C, Calafiore R, Luca G, Marinucci L. Acute effects of lead on porcine neonatal Sertoli cells in vitro. Toxicol In Vitro. 2018 Apr;48:45-52. doi: 10.1016/j.tiv.2017.12.013. Epub 2017 Dec 19.
  9. 9.
    9. Esposito E, Sguizzato M, Drechsler M, Mariani P, Carducci F, Nastruzzi C, Cortesi R. Progesterone lipid nanoparticles: Scaling up and in vivo human study. Eur J Pharm Biopharm. 2017 Oct;119:437-446. doi: 10.1016/j.ejpb.2017.07.015. Epub 2017 Jul 29.
  10. 10.
    10. Angelozzi M, Penolazzi L, Mazzitelli S, Lambertini E, Lolli A, Piva R, Nastruzzi C. Dedifferentiated Chondrocytes in Composite Microfibers As Tool for Cartilage Repair. Front Bioeng Biotechnol. 2017 Jun 13;5:35. doi: 10.3389/fbioe.2017.00035. eCollection 2017

Dottorati di ricerca

Componente UO

Nastruzzi Claudio
Rita Cortesi
Elisabetta Esposito

Dottorato di ricerca

Scienze Chimiche
Scienze Chimiche
Scienze Chimiche

Coordinatore

Alberto Cavazzini
Alberto Cavazzini
Alberto Cavazzini

Sede

Università di Ferrara
Università di Ferrara
Università di Ferrara