role of the microRNAs in the induction of cellular senescence/aging regulation of differentiation of embryonic stem cells (ESC) and regulation of the response to genotoxic stress molecular mechanisms responsible for the acquisition/maintenance of polarity in epithelial cells and molecular mechanism by which trisomy of chromosome 21 (Hsa21) causes the Down syndrome (DS) phenotype role and therapeutic use of non-coding RNAs in different types of human tumors mechanisms of intracellular traffiking of GPI-anchored proteins in healt and diseases role of the putative oncosuppressor HIPK2 in cytokinesis and induction of chromosomal instability role of intracellular trafficking in the pathogenesis of Prion disease and role of the folding in the endoplasmic reticulum and rafts association in the conversion of the prion proteins