- Non-invasive prenatal diagnosis of single point mutations causing inherited genetic disease using advanced technologies such as droplet digital PCR and SPR-based biosensors. -Investigation of signaling pathway and secretomic profile in Shwachman-Diamond Syndrome. -Non coding RNA modulation as innovative therapeutic strategy in thalassemia and cystic fibrosis. -Identification of novel compounds as inducers of erythroid differentiation for β-thalassemia and sickle cell disease. -Analysis of the effects in vivo of molecules of interest in the therapy of β-thalassemia: the zebrafish model. -Analysis of anti-inflammatory molecules and inflammatory pathways for cystic fibrosis, COPD disease and Shwachman-Diamond syndrome. - Identification of novel anti-inflammatory agents and CFTR-modulators for cystic fibrosis. -Read-through strategy for the treatments of genetic rare diseases caused by nonsense mutations such as cystic fibrosis and Shwachman-Diamond syndrome. -Peptide nucleic acids as tool for the development of innovative protocols in the diagnosis of genetic diseases using SPR technologies: β-thalassemia, cystic fibrosis, sickle-cell disease. -Biological and diagnostic applications of dielectrophoresis (DEP) based Lab-on-a-chip devices to diagnosis and drug research and development. -Studies on the anti-proliferative and pro-apoptotic activities of natural or synthetic derivatives.