BIANCHI MICHELE MARIA


Responsabile dell'U.O.

Cognome e Nome

BIANCHI MICHELE MARIA

Qualifica

PA

Dipartimento

Biologia e Biotecnologie Charles Darwin

Settore scientifico disciplinare

CHEM-07/C

E-mail

michele.bianchi@uniroma1.it

Telefono

0649912215

Personale strutturato

Cognome e Nome

Rinaldi Teresa

Qualifica

PA

Dipartimento

Biologia e Biotecnologie Charles Darwin

Ente di appartenenza

Sapienza Università di Roma

Cognome e Nome

Cristina Mazzoni

Qualifica

PA

Dipartimento

Biologia e Biotecnologie Charles Darwin

Ente di appartenenza

Sapienza Università di Roma

Cognome e Nome

Daniela Uccelletti

Qualifica

PO

Dipartimento

Biologia e Biotecnologie Charles Darwin

Ente di appartenenza

Sapienza Università di Roma

Personale non strutturato

Linee di ricerca

Prof. Bianchi: response of yeast(s) to environmental factors, light and hypoxia. Cellular, physiological and metabolic aspects. Use of yeasts(s) for the production of chemicals, proteins and metabolites of industrial interest and their applications. Prof. Rinaldi: one line of research focuses on the use of yeast and bacteria for the study and selection of molecules of pharmaceutical interest, synthetic peptides and small molecules. The second line relates to the Biotechnology of cultural heritage, the selection of green molecules for the protection and bioconservation of cultural heritage, the geomicrobiology of underground environments and carbonate-forming bacteria for bioremediation. Prof. Mazzoni studies programmed cell death using yeast as a model. Her studies have also examined the effects of pharmaceutical molecules and natural extracts, as well as human gene expression, on oxidative stress and longevity, as well as the production of nutraceutical products. Recently, Prof. Mazzoni has expanded her research to analyze microbial biodiversity in extreme environments for astrobiology and biotechnological applications, focusing on biomineralization. She aims to develop "Nature Based Next-Gen Carbon Capture" by utilizing microorganisms' metabolic capabilities. Prof. Uccelletti: her research interests focus on various areas of microbial biotechnology and on the use of the nematode C. elegans as a model organism for toxicological and aging studies. In addition, she is interested in the use of bioactive molecules derived from plant matrices, their by-products, and alternative sources for the evaluation of antimicrobial and antioxidant properties. More recently, she has developed an interest in the production of microbial polymers for various fields of application.

Tecnologie in uso dall'UO

  1. 1.
    Fermentation in bioreactor

Strumentazione

Denominazione

Bioreactor BiostatQ

Struttura ove la strumentazione è allocata

Biologia e Biotecnologie Charles Darwin

Responsabile

Bianchi

Pubblicazioni

  1. 1.
    Oxidative deterioration of polypropylene by redox mediators and yeast expressing a fungal recombinant laccase Sabellico G., Baggetta A., Sandrucci E., Zanellato G., Martinelli A., Montanari A. and Bianchi M.M. INT. BIODETER. BIODEGR. (doi: 10.1016/j.ibiod.2024.105947) 196, 105947 (2025).
  2. 2.
    Light stress in yeasts: signaling and responses in creatures of the night Camponeschi I., Montanari A., Mazzoni C. and Bianchi M.M. INT. J. MOL. SCI. (doi: 10.3390/ijms24086929) 24, 6929 (2023).
  3. 3.
    Light-stress response mediated by the transcription factor KlMga2 in the yeast Kluyveromyces lactis Camponeschi I., Montanari A., Beccaccioli M., Reverberi M., Mazzoni C. and Bianchi M.M. FRONT. MICROBIOL. doi: 10.3389/fmicb.2021.705012 (2021).
  4. 4.
    Phenotypic suppression caused by resonance with light-dark cycles indicates the presence of a 24-hours oscillator in yeast and suggests a new role of intrinsically disordered protein regions as internal mediators Camponeschi I., Damasco A., Uversky V.N., Giuliani A. and Bianchi M.M. J. BIOMOL. STRUCTURE & DYNAMICS. (doi:10.1080/07391102.2020.1749133) 39, 2490–2501 (2021).
  5. 5.
    In Kluyveromyces lactis a pair of paralogous isozymes catalyze the first committed step of leucine biosynthesis in either the mitochondria or the cytosol Aguirre-López B., Escalera-Fanjul X., Hersch-González J., Rojas-Ortega E., El-Hafidi M., Lezama M., González J., Bianchi M.M., López G., Márquez D., Scazzocchio C., Riego-Ruiz L. and González A. FRONT. MICROBIOL. (doi: 10.3389/FMICB.2020.01843) 11, 1843 (2020).
  6. 6.
    The hypoxic expression of the glucose transporter RAG1 reveals the role of the bHLH transcription factor Sck1 as a novel hypoxic modulator in Kluyveromyces lactis Santomartino R., Ottaviano D., Camponeschi I., Alcarpio Landicho T.A., Falato L., Visca A., Soulard A., Lemaire M. and Bianchi M.M. FEMS YEAST RES. 19, foz041 (doi: 10.1093/femsyr/foz041) (2019).
  7. 7.
    The hypoxic transcription factor KlMga2 mediates the response to oxidative stress and influences longevity in the yeast Kluyveromyces lactis Santomartino R., Camponeschi I., Polo G., Immesi A., Rinaldi T., Mazzoni C., Brambilla L. and Bianchi M.M. FEMS YEAST RES. 19, foz020 (doi: 10.1093/femsyr/foz020) (2019).
  8. 8.
    Three, two, one yeast fatty acid desaturases: regulation and function Santomartino R., Riego-Ruiz L. and Bianchi M.M. WORLD J. MICROBIOL. BIOTECHNOL. (doi: 10.1007/s11274-017-2257-y) 33, 89 (2017).
  9. 9.
    Functional roles of the fatty acid desaturases encoded by KlOLE1, FAD2 and FAD3 in the yeast Kluyveromyces lactis De Angelis L., Rinaldi T., Cirigliano A., Bello C., Reverberi M., Amaretti A., Montanari A., Santomartino R., Raimondi S., Gonzalez A. and Bianchi M.M. MICROBIOLOGY (doi: 10.1099/mic.0.000315) 162, 1435-45 (2016).
  10. 10.
    Epigenetic and posttranslational modifications in light signal transduction and the circadian clock in Neurospora crassa Proietto M., Bianchi M.M., Ballario P. and Brenna A. INT. J. MOL. SCI. (doi:10.3390/ijms160715347) 16, 15347-15383 (2015).

Dottorati di ricerca

Componente UO

Teresa Rinaldi
Cristina Mazzoni
Daniela Uccelletti

Dottorato di ricerca

Biologia Cellulare e Sviluppo
Biologia Cellulare e Sviluppo
Biologia Cellulare e Sviluppo

Coordinatore

Prof. Simone Ferrari
Prof. Simone Ferrari
Prof. Simone Ferrari

Sede

Sapienza Università di Roma
Sapienza Università di Roma
Sapienza Università di Roma