MARTINI FERNANDA

Responsabile dell'U.O.

Cognome e Nome

MARTINI FERNANDA

Qualifica

PA

Dipartimento

Department of Medical Sciences

Settore scientifico disciplinare

BIOS-10/A

E-mail

fernanda.martini@unife.it

Telefono

+39 0532455538

Personale strutturato

Cognome e Nome

Mazzoni Elisa

Qualifica

PA

Dipartimento

Department of Chemical, Pharmaceutical and Agricultural Sciences

Ente di appartenenza

University of Ferrara

Cognome e Nome

De Mattei Monica

Qualifica

PA

Dipartimento

Department of Medical Sciences

Ente di appartenenza

University of Ferrara

Cognome e Nome

Tognon Mauro

Qualifica

Professore emerito

Dipartimento

Department of Medical Sciences

Ente di appartenenza

University of Ferrara

Personale non strutturato

Cognome e Nome

Tonnini Giulia

Qualifica

Ph.D student

Dipartimento

Department of Medical Sciences

Ente di appartenenza

University of Ferrara

Cognome e Nome

Mazziotta Chiara

Qualifica

Post-doc

Dipartimento

Department of Medical Sciences

Ente di appartenenza

University of Ferrara

Cognome e Nome

Badiale Giada

Qualifica

Borsista

Dipartimento

Department of Medical Sciences

Ente di appartenenza

University of Ferrara

Cognome e Nome

Oimo Milena

Qualifica

Borsista

Dipartimento

Department of Medical Sciences

Ente di appartenenza

University of Ferrara

Cognome e Nome

Cervellera Christian Felice

Qualifica

Ph.D student

Dipartimento

Department of Medical Sciences

Ente di appartenenza

University of Ferrara

Cognome e Nome

Tramarin Maria Letizia

Qualifica

Ph.D student

Dipartimento

Department of Medical Sciences

Ente di appartenenza

University of Ferrara

Cognome e Nome

De Pace Raffaella

Qualifica

Ph.D student

Dipartimento

Department of Medical Sciences

Ente di appartenenza

University of Ferrara

Cognome e Nome

Iaquinta Maria Rosa

Qualifica

Post-doc

Dipartimento

Department of Medical Sciences

Ente di appartenenza

University of Ferrara

Linee di ricerca

Our laboratory carries out research in cell and molecular biology applied to oncology and regenerative medicine. In particular, we are working on two tumours: pleural mesothelioma (PM) and Merkel cell carcinoma (MCC). PM is a rare but very aggressive tumour of the pleura. We are studying the role of a serum protein, alpha-1-antitrypsin (AAT), in tumourigenesis and non-coding RNAs (ncRNAs) in the diagnosis and prognosis of this tumour. MCC is also a rare but very aggressive tumour of the skin, caused in 80% of cases by the Merkel cell polyoma virus (MCPyV). Studies in this case are focused on finding new therapeutic strategies to treat this tumour. Regenerative medicine research is investigating new biomaterials to regenerate bone tissue.

Tecnologie in uso dall'UO

  1. 1.
    ddPCR
  2. 2.
    Real time PCR
  3. 3.
    Western Blot
  4. 4.
    Immunofluorescence
  5. 5.
    Cell culture

Strumentazione

Denominazione

QX200 Droplet Digital PCR (ddPCR) System
QX200 AutoDG Droplet Digital PCR System

Struttura ove la strumentazione è allocata

CUBO-Via Fossato di Mortara, 70
CUBO-Via Fossato di Mortara, 70

Responsabile

Fernanda Martini
Fernanda Martini

Pubblicazioni

  1. 1.
    Mazziotta C, Badiale G, Cervellera CF, Tonnini G, Oimo M, Touzé A, Arnold F, Zanussi S, Schioppa O, Fanetti G, Tognon M, Martini F, Rotondo JC. Serum antibodies against mimotopes of Merkel cell polyomavirus oncoproteins detected by a novel immunoassay in healthy individuals and Merkel cell carcinoma patients. Microbial Biotechnology. 2024. 17(10):e14536.
  2. 2.
    Mazziotta C, Badiale G, Cervellera CF, Morciano G, Di Mauro G, Touzé A, Pinton P, Tognon Martini F, Rotondo JC. All-trans retinoic acid exhibits anti-proliferative and differentiating activity in Merkel cell carcinoma cells via retinoid pathway modulation. J Eur Acad Dermatol Venereol. 2024 Jul;38(7):1419-1431.
  3. 3.
    Lanzillotti C, Iaquinta MR, De Pace R, Mosaico M, Patergnani S, Giorgi C, Tavoni M, Dapporto M, Sprio S, Tampieri A, Montesi M, Martini F, Mazzoni E. Osteosarcoma cell death induced by innovative scaffolds doped with chemotherapeutics. J Cell Physiol. 2024 May;239(5):e31256.
  4. 4.
    Nicol JTJ, Mazzoni E, Iaquinta MR, De Pace R, Gaboriaud P, Maximova N, Cason C, De Martino E, Mazziotta C, Coursaget P, Touzé A, Boz V, Comar M, Tognon M, Martini F. Prevalence of IgG antibodies against Malawi polyomavirus in patients with autoimmune diseases and lymphoproliferative disorders subjected to bone marrow transplantation. Front Immunol. 2024 Jan 17:14:1293313.
  5. 5.
    Mazzoni E, Di Stefano M, Fiore JR, Destro F, Manfrini M, Rotondo JC, Casali MV, Vesce F, Greco P, Scutiero G, Martini F, Tognon M. Corrigendum: Serum IgG antibodies from pregnant women reacting to mimotopes of Simian virus 40 large T antigen, the viral oncoprotein. Front Immunol. 2024 Jan 5:14:1329317.
  6. 6.
    Mazziotta C, Badiale G, Cervellera CF, Tognon M, Martini F, Rotondo JC. Regulatory mechanisms of circular RNAs during human mesenchymal stem cell osteogenic differentiation. Theranostics. 2024 Jan 1;14(1):143-158.
  7. 7.
    Bellu E, Garroni G, Cruciani S, Balzano F, Serra D, Satta D, Montesu MA, Fadda A, Mulas M, Sarais G, Bandiera P, Torreggiani E, Martini F, Tognon M, Ventura C, Beznoska J, Amler E, Maioli M. Correction: Bellu et al. Smart Nanofibers with Natural Extracts Prevent Senescence Patterning in a Dynamic Cell Culture Model of Human Skin. Cells 2020, 9, 2530. Cells. 2024 Jul 31;13(15):1285.
  8. 8.
    Tognon M, Martini F, Rotondo JC, Fiume G. Editorial: Recent advances in diagnosis, prognosis, and therapy of oncogenic virus-driven tumors. Front Oncol. 2024 Apr 10:14:1402877.
  9. 9.
    Mazziotta C, Iaquinta MR, Tramarin ML, Badiale G, Cervellera CF, Tonnini G, Patergnani S, Pinton P, Lanza G, Gafà R, Tognon M, Martini F, De Mattei M, Rotondo JC. Hsa-microRNA-1249-3p/Homeobox A13 axis modulates the expression of β-catenin gene in human epithelial cells. Sci Rep. 2023 Dec 18;13(1):22872.
  10. 10.
    Mazzoni E, Iaquinta MR, Mosaico M, De Pace R, D'Agostino A, Tognon M, Martini F. Human Mesenchymal Stem Cells and Innovative Scaffolds for Bone Tissue Engineering Applications. Tissue Eng Part B Rev. 2023 Oct;29(5):514-531.

Dottorati di ricerca

Componente UO

Fernanda Martini
Elisa Mazzoni
Monica De Mattei

Dottorato di ricerca

Medical, omics and oncological sciences
Medical, omics and oncological sciences
Medical, omics and oncological sciences

Coordinatore

Paolo Pinton
Paolo Pinton
Paolo Pinton

Sede

University of Ferrara
University of Ferrara
University of Ferrara