The Physiology lab of Tuscia University is mainly aimed to investigate (neuro-) physiopathological phenomena affecting the transport and signaling pathways, the dynamics of death and survival, the molecular receptors/targets and the substances that control them, with a mechanistic and translational approach in cell and tissue functions. In particular: • Physiology of skeletal muscle and neuromuscular diseases. Mitochondria, metabolism, myogenesis and regeneration. Molecular mechanisms of proliferation and differentiation of satellite cells. Central and peripheral nerve components. New targets and therapeutic strategies, including nutraceuticals, of translational interest. • Neurodegeneration and neuroprotection. Retina, nerve circuits, synapses. Neurotoxicity, hypoxic, metabolic and ischemic stress. Neuropeptides, nutraceuticals, oxidative stress and protection strategies of neurons and the glial component. • Dynamics and signaling of autophagy, apoptosis and death/survival processes in cells and tissues, including neurons, nerve structures, and transformed (tumoural) cells. • Natural substances and synthetic analogues of pharmacological interest. Nutraceutical substances. Functional properties, molecular mechanisms and potential applications. The Physical Chemistry lab is aimed at the molecular understanding of the relationship between a specific biological function and the dynamic and structural characteristics of the bioactive peptide; the chemical-physical characterization of the interaction between the peptide or the protein and the biological membranes; the definition of structural determinants capable of regulating the specificity and directing the activity of a given bioactive molecule; design and design of new peptides with high specificity of action and selectivity.