Responsabile dell'U.O.
Cognome e Nome
Calonghi Natalia
Qualifica
PA
Dipartimento
Pharmacy and Biotechnology
Settore scientifico disciplinare
BIO/10
natalia.calonghi@unibo.it
Telefono
Personale strutturato
Cognome e Nome
Sartor Giorgio
Qualifica
PA
Dipartimento
Pharmacy and Biotechnology
Ente di appartenenza
Alma Mater Studiorum – Università di Bologna
Cognome e Nome
Fato Romana
Qualifica
PA
Dipartimento
Pharmacy and Biotechnology
Ente di appartenenza
Alma Mater Studiorum – Università di Bologna
Cognome e Nome
Boga Carla
Qualifica
Ricercatore
Dipartimento
Pharmacy and Biotechnology
Ente di appartenenza
Alma Mater Studiorum – Università di Bologna
Cognome e Nome
Passerini Nadia
Qualifica
PA
Dipartimento
Pharmacy and Biotechnology
Ente di appartenenza
Alma Mater Studiorum – Università di Bologna
Cognome e Nome
Albertini Beatrice
Qualifica
PA
Dipartimento
Pharmacy and Biotechnology
Ente di appartenenza
Alma Mater Studiorum – Università di Bologna
Cognome e Nome
Luppi Barbara
Qualifica
PA
Dipartimento
Pharmacy and Biotechnology
Ente di appartenenza
Alma Mater Studiorum – Università di Bologna
Cognome e Nome
Bergamini Christian
Qualifica
RTDB
Dipartimento
Pharmacy and Biotechnology
Ente di appartenenza
Alma Mater Studiorum – Università di Bologna
Personale non strutturato
Cognome e Nome
Parolin Carola
Qualifica
Borsista
Dipartimento
Pharmacy and Biotechnology
Ente di appartenenza
Alma Mater Studiorum – Università di Bologna
Cognome e Nome
Abruzzo Angela
Qualifica
Borsista
Dipartimento
Pharmacy and Biotechnology
Ente di appartenenza
Alma Mater Studiorum – Università di Bologna
Cognome e Nome
Wenping Wang
Qualifica
Ph.D student
Dipartimento
Pharmacy and Biotechnology
Ente di appartenenza
Alma Mater Studiorum – Università di Bologna
Cognome e Nome
Bertoni Serena
Qualifica
Ph.D student
Dipartimento
Pharmacy and Biotechnology
Ente di appartenenza
Alma Mater Studiorum – Università di Bologna
Linee di ricerca
Role of HDAC1 dependent co-regulating complexes in carcinogenesis
Study of calcification mechanism in marine organisms
Structure and function of mitochondrial Complex I
Complex I production of Reactive Oxygen Specie
Study on the effect of toxicants on the functionality of mitochondrial respiratory chain
Development and characterization of innovative systems (micro- and nano- particles, liposomes) for the delivery of Active Pharmaceutical Ingredients: drugs, peptides, proteins, nucleic acids and cells (i.e. probiotic bacteria)
Synthesis of long- and short-chain lipid peroxidation products such as 4-hydroxy-trans-2-nonenal and hydroxystearic acids and their derivatives. Synthesis and reactivity of organic compounds containing the aza group. Identification and characterization of products and of labile intermediates of organic reactions through NMR spectroscopy studies (1H, 13C, 31P)
Tecnologie in uso dall'UO
- Confocal Microscopy
- Production and characterization of liposomes, nano- and micro- particles.
- Western Blot, RT-PCR, Real time PCR, ChIP
- Flow cytometry
- Gene silencing
- HPLC
- Synthesis, characterization of intermediates and organic compounds using advanced NMR spectroscopy techniques
- Cell transfection
- Drug permeation and drug release
- Spectrophotometry and Spectrofluorometry
Strumentazione
Denominazione
confocal laser-scanning microscope
MRC1024 confocal laser microscope
Fluorimenter Photon Technology International
Beckman Coulter flow cytometer
HPLC
Aktapurifier GE Healthcare
RT-PCR
High Field NMR Spectrometers
Gas. Chromatograph Mass Spectrometer Agilent
Spray-dryer, Spray-congealer, Freeze-dryer
HPLC with autosampler
Dynamic Light Scattering
Differential Scanning Calorimetry
Struttura ove la strumentazione è allocata
CIRB
CIRB
CIRB
CIRB
CIRB
CIRB
CIRB
Faculty of Industrial Chemistry
Science and Technology of Industrial Chemistry
Dept. of Pharmacy and Biotechnology
Dept. of Pharmacy and Biotechnology
Dept. of Pharmacy and Biotechnology
Dept. of Pharmacy and Biotechnology
Responsabile
Calonghi
Calonghi
Sartor
Faruggia
Sartor
Sartor
Capranico
Mazzanti
Boga
Passerini/Luppi
Passerini/Luppi
Passerini/Luppi
Passerini/Luppi
Pubblicazioni
- Parolin C, Marangoni A, Laghi L, Foschi C, Ñahui Palomino RA, Calonghi N, Cevenini R, Vitali B. PLoS One. 2015 Jun 22;10(6):e01312201. Isolation of Vaginal Lactobacilli and Characterization of Anti-Candida Activity.
- Anal Bioanal Chem. 2013 Jan;405(2-3):795-804Bartolini M, Naldi M, Nicolau DV, van Delft FC, van Zijl J, Snijder J, van den Heuvel EF, Naburgh EP, Calonghi N, Andrisano V.2. Fluorescence biosensing micropatterned surfaces based on immobilized human acetylcholinesterase.
- Biochim Biophys Acta. 2012 Oct;1821(10):1334-40.Parolin C, Calonghi N, Presta E, Boga C, Caruana P, Naldi M, Andrisano V, Masotti L, Sartor G.in colon cancer.3. Mechanism and stereoselectivity of HDAC I inhibition by (R)-9-hydroxystearic acid
- Int J Pharm. 2013 Jan 20;440(2):238-49Albertini B, Di Sabatino M, Calonghi N, Rodriguez L, Passerini N.4. Novel multifunctional platforms for potential treatment of cutaneous wounds: development and in vitro characterization.
- Int J Pharm. 2014 Jul 20;469(1):67-79Albertini B, Di Sabatino M, Melegari C, Passerini N.5. Formulating SLMs as oral pulsatile system for potential delivery of melatonin to pediatric population.
- Eur J Pharm Sci. 2012 Aug 15;46(5):346-56Di Sabatino M, Albertini B, Kett VL, Passerini N.Spray congealed lipid microparticles with high protein loading: preparation and solid state characterisation.
- PLoS One. 2012;7(3):e33712Bergamini C, Moruzzi N, Sblendido A, Lenaz G, Fato R.A water soluble CoQ10 formulation improves intracellular distribution and promotes mitochondrial respiration in cultured cells.
- PLoS One. 2014 Sep 30;9(9):e108112Aldini R, Micucci M, Cevenini M, Fato R, Bergamini C, Nanni C, Cont M, Camborata C, Spinozzi S, Montagnani M, Roda G, D'Errico-Grigioni A, Rosini F, Roda A, Mazzella G, Chiarini A, Budriesi R.8. Antiinflammatory effect of phytosterols in experimental murine colitis model: prevention, induction, remission study.
- J Med Chem. 2014 Oct 23;57(20):8576-89Nepovimova E, Uliassi E, Korabecny J, Peña-Altamira LE, Samez S, Pesaresi A, Garcia GE, Bartolini M, Andrisano V, Bergamini C, Fato R, Lamba D, Roberti M, Kuca K, Monti B, Bolognesi ML.9. Multitarget drug design strategy: quinone-tacrine hybrids designed to block amyloid-β aggregation and to exert anticholinesterase and antioxidant effects.
- J Med Chem. 2015 Aug 27;58(16):6422-34Prati F, Bergamini C, Molina MT, Falchi F, Cavalli A, Kaiser M, Brun R, Fato R, Bolognesi ML.10. 2-Phenoxy-1,4-naphthoquinones: From a Multitarget Antitrypanosomal to a Potential Antitumor Profile.
Dottorati di ricerca
Componente UO
Calonghi Natalia
Luppi Barbara
Fato Romana
Dottorato di ricerca
Biotechnological and Pharmaceutical Sciencess
Biotechnological and Pharmaceutical Sciencess
Biotechnological and Pharmaceutical Sciencess
Coordinatore
Prof. Santi Mario Spampinato
Prof. Santi Mario Spampinato
Prof. Santi Mario Spampinato
Sede
FaBiT
FaBiT
FaBiT