Calonghi Natalia


Responsabile dell'U.O.

Cognome e Nome

Calonghi Natalia

Qualifica

PA

Dipartimento

Pharmacy and Biotechnology

Settore scientifico disciplinare

BIO/10

E-mail

natalia.calonghi@unibo.it

Telefono

Personale strutturato

Cognome e Nome

Sartor Giorgio

Qualifica

PA

Dipartimento

Pharmacy and Biotechnology

Ente di appartenenza

Alma Mater Studiorum – Università di Bologna

Cognome e Nome

Fato Romana

Qualifica

PA

Dipartimento

Pharmacy and Biotechnology

Ente di appartenenza

Alma Mater Studiorum – Università di Bologna

Cognome e Nome

Boga Carla

Qualifica

Ricercatore

Dipartimento

Pharmacy and Biotechnology

Ente di appartenenza

Alma Mater Studiorum – Università di Bologna

Cognome e Nome

Passerini Nadia

Qualifica

PA

Dipartimento

Pharmacy and Biotechnology

Ente di appartenenza

Alma Mater Studiorum – Università di Bologna

Cognome e Nome

Albertini Beatrice

Qualifica

PA

Dipartimento

Pharmacy and Biotechnology

Ente di appartenenza

Alma Mater Studiorum – Università di Bologna

Cognome e Nome

Luppi Barbara

Qualifica

PA

Dipartimento

Pharmacy and Biotechnology

Ente di appartenenza

Alma Mater Studiorum – Università di Bologna

Cognome e Nome

Bergamini Christian

Qualifica

RTDB

Dipartimento

Pharmacy and Biotechnology

Ente di appartenenza

Alma Mater Studiorum – Università di Bologna

Personale non strutturato

Cognome e Nome

Parolin Carola

Qualifica

Borsista

Dipartimento

Pharmacy and Biotechnology

Ente di appartenenza

Alma Mater Studiorum – Università di Bologna

Cognome e Nome

Abruzzo Angela

Qualifica

Borsista

Dipartimento

Pharmacy and Biotechnology

Ente di appartenenza

Alma Mater Studiorum – Università di Bologna

Cognome e Nome

Wenping Wang

Qualifica

Ph.D student

Dipartimento

Pharmacy and Biotechnology

Ente di appartenenza

Alma Mater Studiorum – Università di Bologna

Cognome e Nome

Bertoni Serena

Qualifica

Ph.D student

Dipartimento

Pharmacy and Biotechnology

Ente di appartenenza

Alma Mater Studiorum – Università di Bologna

Linee di ricerca

Role of HDAC1 dependent co-regulating complexes in carcinogenesis Study of calcification mechanism in marine organisms Structure and function of mitochondrial Complex I Complex I production of Reactive Oxygen Specie Study on the effect of toxicants on the functionality of mitochondrial respiratory chain Development and characterization of innovative systems (micro- and nano- particles, liposomes) for the delivery of Active Pharmaceutical Ingredients: drugs, peptides, proteins, nucleic acids and cells (i.e. probiotic bacteria) Synthesis of long- and short-chain lipid peroxidation products such as 4-hydroxy-trans-2-nonenal and hydroxystearic acids and their derivatives. Synthesis and reactivity of organic compounds containing the aza group. Identification and characterization of products and of labile intermediates of organic reactions through NMR spectroscopy studies (1H, 13C, 31P)

Tecnologie in uso dall'UO

  1. 1.
    Confocal Microscopy
  2. 2.
    Production and characterization of liposomes, nano- and micro- particles.
  3. 3.
    Western Blot, RT-PCR, Real time PCR, ChIP
  4. 4.
    Flow cytometry
  5. 5.
    Gene silencing
  6. 6.
    HPLC
  7. 7.
    Synthesis, characterization of intermediates and organic compounds using advanced NMR spectroscopy techniques
  8. 8.
    Cell transfection
  9. 9.
    Drug permeation and drug release
  10. 10.
    Spectrophotometry and Spectrofluorometry

Strumentazione

Denominazione

confocal laser-scanning microscope
MRC1024 confocal laser microscope
Fluorimenter Photon Technology International
Beckman Coulter flow cytometer
HPLC
Aktapurifier GE Healthcare
RT-PCR
High Field NMR Spectrometers
Gas. Chromatograph Mass Spectrometer Agilent
Spray-dryer, Spray-congealer, Freeze-dryer
HPLC with autosampler
Dynamic Light Scattering
Differential Scanning Calorimetry

Struttura ove la strumentazione è allocata

CIRB
CIRB
CIRB
CIRB
CIRB
CIRB
CIRB
Faculty of Industrial Chemistry
Science and Technology of Industrial Chemistry
Dept. of Pharmacy and Biotechnology
Dept. of Pharmacy and Biotechnology
Dept. of Pharmacy and Biotechnology
Dept. of Pharmacy and Biotechnology

Responsabile

Calonghi
Calonghi
Sartor
Faruggia
Sartor
Sartor
Capranico
Mazzanti
Boga
Passerini/Luppi
Passerini/Luppi
Passerini/Luppi
Passerini/Luppi

Pubblicazioni

  1. 1.
    Parolin C, Marangoni A, Laghi L, Foschi C, Ñahui Palomino RA, Calonghi N, Cevenini R, Vitali B. PLoS One. 2015 Jun 22;10(6):e01312201. Isolation of Vaginal Lactobacilli and Characterization of Anti-Candida Activity.
  2. 2.
    Anal Bioanal Chem. 2013 Jan;405(2-3):795-804Bartolini M, Naldi M, Nicolau DV, van Delft FC, van Zijl J, Snijder J, van den Heuvel EF, Naburgh EP, Calonghi N, Andrisano V.2. Fluorescence biosensing micropatterned surfaces based on immobilized human acetylcholinesterase.
  3. 3.
    Biochim Biophys Acta. 2012 Oct;1821(10):1334-40.Parolin C, Calonghi N, Presta E, Boga C, Caruana P, Naldi M, Andrisano V, Masotti L, Sartor G.in colon cancer.3. Mechanism and stereoselectivity of HDAC I inhibition by (R)-9-hydroxystearic acid
  4. 4.
    Int J Pharm. 2013 Jan 20;440(2):238-49Albertini B, Di Sabatino M, Calonghi N, Rodriguez L, Passerini N.4. Novel multifunctional platforms for potential treatment of cutaneous wounds: development and in vitro characterization.
  5. 5.
    Int J Pharm. 2014 Jul 20;469(1):67-79Albertini B, Di Sabatino M, Melegari C, Passerini N.5. Formulating SLMs as oral pulsatile system for potential delivery of melatonin to pediatric population.
  6. 6.
    Eur J Pharm Sci. 2012 Aug 15;46(5):346-56Di Sabatino M, Albertini B, Kett VL, Passerini N.Spray congealed lipid microparticles with high protein loading: preparation and solid state characterisation.
  7. 7.
    PLoS One. 2012;7(3):e33712Bergamini C, Moruzzi N, Sblendido A, Lenaz G, Fato R.A water soluble CoQ10 formulation improves intracellular distribution and promotes mitochondrial respiration in cultured cells.
  8. 8.
    PLoS One. 2014 Sep 30;9(9):e108112Aldini R, Micucci M, Cevenini M, Fato R, Bergamini C, Nanni C, Cont M, Camborata C, Spinozzi S, Montagnani M, Roda G, D'Errico-Grigioni A, Rosini F, Roda A, Mazzella G, Chiarini A, Budriesi R.8. Antiinflammatory effect of phytosterols in experimental murine colitis model: prevention, induction, remission study.
  9. 9.
    J Med Chem. 2014 Oct 23;57(20):8576-89Nepovimova E, Uliassi E, Korabecny J, Peña-Altamira LE, Samez S, Pesaresi A, Garcia GE, Bartolini M, Andrisano V, Bergamini C, Fato R, Lamba D, Roberti M, Kuca K, Monti B, Bolognesi ML.9. Multitarget drug design strategy: quinone-tacrine hybrids designed to block amyloid-β aggregation and to exert anticholinesterase and antioxidant effects.
  10. 10.
    J Med Chem. 2015 Aug 27;58(16):6422-34Prati F, Bergamini C, Molina MT, Falchi F, Cavalli A, Kaiser M, Brun R, Fato R, Bolognesi ML.10. 2-Phenoxy-1,4-naphthoquinones: From a Multitarget Antitrypanosomal to a Potential Antitumor Profile.

Dottorati di ricerca

Componente UO

Calonghi Natalia
Luppi Barbara
Fato Romana

Dottorato di ricerca

Biotechnological and Pharmaceutical Sciencess
Biotechnological and Pharmaceutical Sciencess
Biotechnological and Pharmaceutical Sciencess

Coordinatore

Prof. Santi Mario Spampinato
Prof. Santi Mario Spampinato
Prof. Santi Mario Spampinato

Sede

FaBiT
FaBiT
FaBiT