De Flora Antonio

Professore Ordinario

Medicina e Chirurgia

Medicina Sperimentale (DIMES), Sezione di Biochimica, Università di Genova

BIO10 - Biochimica

Cognome e Nome

De Flora Antonio

Qualifica

Full Professor

Dipartimento

Dept. of Experimental Medicine (DIMES), Section of Biochemistry

Ente di appartenenza

University of Genova

Cognome e Nome

Leoncini Giuliana

Qualifica

Full Professor

Dipartimento

Dept. of Experimental Medicine (DIMES), Section of Biochemistry

Ente di appartenenza

University of Genova

Cognome e Nome

Zocchi Elena

Qualifica

Full Professor

Dipartimento

Dept. of Experimental Medicine (DIMES), Section of Biochemistry

Ente di appartenenza

University of Genova

Cognome e Nome

Basile Giovanna

Qualifica

Research Fellow

Dipartimento

Dept. of Experimental Medicine (DIMES), Section of Biochemistry

Ente di appartenenza

University of Genova

Cognome e Nome

Bodrato Nicoletta

Qualifica

Ph D Student

Dipartimento

Dept. of Experimental Medicine (DIMES), Section of Biochemistry

Ente di appartenenza

University of Genova

Cognome e Nome

Bruzzese Debora

Qualifica

Ph D Student

Dipartimento

Dept. of Experimental Medicine (DIMES), Section of Biochemistry

Ente di appartenenza

University of Genova

Cognome e Nome

Fresia Chiara

Qualifica

Ph D Student

Dipartimento

Dept. of Experimental Medicine (DIMES), Section of Biochemistry

Ente di appartenenza

University of Genova

Cognome e Nome

Magnone Mirko

Qualifica

Ph D Student

Dipartimento

Dept. of Experimental Medicine (DIMES), Section of Biochemistry

Ente di appartenenza

University of Genova

Cognome e Nome

Moreschi Iliana

Qualifica

Ph D Student

Dipartimento

Dept. of Experimental Medicine (DIMES), Section of Biochemistry

Ente di appartenenza

University of Genova

Cognome e Nome

Scarfì Sonia

Qualifica

Research Fellow

Dipartimento

Dept. of Experimental Medicine (DIMES), Section of Biochemistry

Ente di appartenenza

University of Genova

Cognome e Nome

Signorello Maria Grazia

Qualifica

Research Fellow

Dipartimento

Dept. of Experimental Medicine (DIMES), Section of Biochemistry

Ente di appartenenza

University of Genova

1. Subcellular and intercellular trafficking of second messengers causally related to regulation of intracellular calcium homeostasis (Cyclic ADP-ribose, ADP-ribose, NAADP+). Autocrine and paracrine mechanisms and molecular studies on relevant transporter systems and receptors.

2. Biological roles and signalling pathways triggered by extracellular pyridine nucleotides (NAD+, NAADP+).

3. Mechanisms of expansion/differentiation of mesenchymal and hemopoietic stem cells and their impact in biomedicine (bone marrow transplantation, bone regeneration).

4. Biological roles, metabolism and molecular mechanisms of adenylic homodinucleotides generated by ADP-ribosyl cyclases and featuring cytotoxic activities.

5. Biological roles, metabolism and molecular mechanisms of the phytohormone abscisic acid in mammals.

6. Modulation of functional activities of human platelets.

1. Paracrinally stimulated expansion of early hemopoietic progenitors by stroma-generated cyclic ADP-ribose. Zocchi, E., Podestà, M., Pitto, A., Usai, C., Bruzzone, S., Franco, L., Guida, L., Bacigalupo, A., and De Flora, A. FASEB J. 15, 1610-1612, 2001.

2. The temperature-signaling cascade in sponges involves a heat-gated cation channel, abscisic acid, and cyclic ADP-ribose. Zocchi, E., Carpaneto, A., Cerrano, C., Bavestrello, G., Giovine, M., Bruzzone, S., Guida, L., Franco, L., Usai, C. Proc. Natl. Acad. Sci. USA 98, 14859-14864, 2001.

3. Cyclic ADP-ribose generation by CD38 improves human hemopoietic stem cell engraftment into NOD/SCID mice. Podestà, M., Pitto, A., Figari, O., Bacigalupo, A., Bruzzone, S., Guida, L., Franco, L., De Flora, A., and E. Zocchi. FASEB J. 17, 310-312, 2003.

4. Spatio-temporal propagation of Ca2+ signals by cyclic ADP-ribose in 3T3 cells stimulated via purinergic P2Y receptors. Bruzzone, S., Kunerth, S., Zocchi, E., De Flora, A., and Guse, A.H. J. Cell Biol. 163, 837-845, 2003.

5. Concentrative influx of functionally active cyclic ADP-ribose in dimethylsulfoxide-differentiated HL-60 cells. Guida, L., Franco, L., Bruzzone, S., Sturla, L., Zocchi, E., Basile, G., Usai, C. and De Flora, A.. J Biol Chem. 279, 22066-22075, 2004.

6. Abscisic acid signaling through cyclic ADP-ribose in hydroid regeneration. Puce, S., Basile, G., Bavestrello, G., Bruzzone, S., Cerrano, C., Giovine, M., Arillo, A., Zocchi, E. J. Biol. Chem. 279, 39783-39788, 2004.

7. Synthesis and in vitro inhibitory activity on human platelet aggregation of novel properly substituted 4-(1-piperazinyl)coumarins. Di Braccio, M., Grossi, G., Roma, G., Signorello, M.G., Leoncini, G. Eur. J. Med. Chem. 39, 397-409, 2004.

8. The L-arginine/NO pathway in the early phases of platelet stimulation by collagen. Leoncini, G., Bruzzese, D., Signorello, M.G. Biochem. Pharmacol. 69, 289-296, 2005.

9. Concentrative uptake of cyclic ADP-ribose generated by BST-1+ stroma stimulates proliferation of human hematopoietic progenitors. Podestà, M., Benvenuto, F., Pitto, A., Figari, O., Bacigalupo, A., Bruzzone, S., Guida, L., Franco, L., Paleari, L., Bodrato, N., Usai, C., De Flora, A. and Zocchi, E. J. Biol Chem. 280, 5343-5349, 2005.

10. ADP-ribosyl cyclases generate two unusual adenine homodinucleotides with cytotoxic activity on mammalian cells. Basile, G., Taglialatela-Scafati, O., Damonte, G., Armirotti, A., Bruzzone, S., Guida, L., Franco, L., Usai, C., Fattorusso, E., De Flora, A. and Zocchi, E. Proc. Natl. Acad. Sci. USA 102, 14509-14514, 2005.