Nastruzzi Claudio Stampa
RESPONSABILE DELLA U. O.

Cognome e Nome Nastruzzi Claudio
Qualifica Professore Associato
Dipartimento Scienze Chimiche e Farmaceutiche
Settore Scientifico Disciplinare Chim 09
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PERSONALE STRUTTURATO

Cognome e Nome Cortesi Rita
Qualifica PA
Dipartimento Scienze Chimiche e Farmaceutiche
Ente di appartenenza Università di Ferrara
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Cognome e Nome Esposito Elisabetta
Qualifica RTD-B
Dipartimento Scienze Chimiche e Farmaceutiche
Ente di appartenenza Università di Ferrara
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PERSONALE NON STRUTTURATO

Cognome e Nome Sguizzato Maddalena
Qualifica Assegnista di Ricerca
Dipartimento Scienze Chimiche e Farmaceutiche
Ente di appartenenza Università di Ferrara
Cognome e Nome HALLAN Singh Supandeep
Qualifica Dottorando
Dipartimento Scienze Chimiche e Farmaceutiche
Ente di appartenenza Università di Ferrara

LINEE DI RICERCA

Nano- and Micro-systems for drug delivery

Controlled release of biological response modifiers. Production and characterization of particulate delivery systems: liposomes, cubosomes, microspheres for gene therapy

Conduits for nerve repair

Development and optimization of different bioencapsulation methods for the production of conduits for nerve repair. Study of new materials for cell encapsulation and identification of new processes allowing the use of these materials under mild and biocompatible conditions

Lab-on-a-chip

Prodution and characterization of nano- and microparticellar system for biopharmaceutical applications on a Lab-on-a-chip based microelectronic technology"

Phytonutrients

Design, production and characterization of microparticles made of enteric resistant polymers to prevent phytonutrients release to the stomach and to the upper small intestine

Lipospheres

Lipidic microspheres, lipospheres (LS) as new type of fat-based encapsulation system developed for drug delivery of bioactive compounds (especially lipophilic compounds). LS combine the advantages of polymeric nanoparticles, fat emulsions and liposomes avoiding some of their disadvantages, such as cytotoxic effects after phagocytosis, toxic effects of organic residues after the production of polymers, lack of large industrial scale production

Multifunctional microcapsules for islets entrapment

We introduced a new approach for the integrated immunoprotection of transplanted islets, irrespective of the islet origin and maturation level. In this approach, the ‘‘islet compartment’’ benefit from a ‘‘chemical/pharmacologic agent compartment’’ constituted of a sustained release formulation able to deliver the included biological response modifiers for long periods of time

Liposomes, micelles and microemulsions as delivery systems for biological response modifiers

Design and performance of specialized delivery systems (SDSs) such as liposomes, micellar solutions and microemulsions

Prototyping

Rapid prototyping technology for the quick production of three-dimensional objects without expensive tooling techniques during the product development stage


TECNOLOGIE IN POSSESSO DELL'U. O.

  • Nano- and Micro-systems for drug delivery
  • Lab-on-a-chip
  • Lipospheres
  • Liposomes, micelles and microemulsions as delivery systems
  • Prototyping
  • Conduits for nerve repair
  • Phytonutrients
  • Multifunctional microcapsules for islets entrapment
  • Gelatin devices

STRUMENTAZIONE

Denominazione

Struttura ove la strumentazione è allocata

Responsabile della strumentazione

HPLC

Dip. Scienze Chimiche e Farmaceutiche

Claudio Nastruzzi, Rita Cortesi

Spray Drier

Dip. Scienze Chimiche e Farmaceutiche

Claudio Nastruzzi, Rita Cortesi

Vibrating encapsulator

Dip. Scienze Chimiche e Farmaceutiche

Claudio Nastruzzi

DSC

Dip. CScienze Chimiche e Farmaceuticheo

Claudio Nastruzzi

Laser granulometer

Dip. Scienze Chimiche e Farmaceutiche

Claudio Nastruzzi

Zetasizer Nano 90S

Dip. Scienze Chimiche e Farmaceutiche

Rita Cortesi

Rheometer

Dip. Scienze Chimiche e Farmaceutiche

Claudio Nastruzzi

PUBBLICAZIONI

1. Esposito E, Nastruzzi C, Sguizzato M, Cortesi R. Nanomedicines to Treat Skin Pathologies with Natural Molecules. Curr Pharm Des. 2019;25(21):2323-2337. doi: 10.2174/1381612825666190709210703.

2. Esposito E, Sguizzato M, Drechsler M, Mariani P, Carducci F, Nastruzzi C, Valacchi G, Cortesi R. Lipid nanostructures for antioxidant delivery: a comparative preformulation study. Beilstein J Nanotechnol. 2019 Aug 29;10:1789-1801. doi: 10.3762/bjnano.10.174. eCollection 2019.

3. Pitingolo G, Taly V, Nastruzzi C. Coins in microfluidics: From mere scale objects to font of inspiration for microchannel circuits. Biomicrofluidics. 2019 Apr 9;13(2):024106. doi: 10.1063/1.5086535. eCollection 2019 Mar.

4. Pitingolo G, Riaud A, Nastruzzi C, Taly V. Gelatin-Coated Microfluidic Channels for 3D Microtissue Formation: On-Chip Production and Characterization. Micromachines (Basel). 2019 Apr 19;10(4). pii: E265. doi: 10.3390/mi10040265.

5. Esposito E, Pecorelli A, Sguizzato M, Drechsler M, Mariani P, Carducci F, Cervellati F, Nastruzzi C, Cortesi R, Valacchi G. Production and Characterization of Nanoparticle Based Hyaluronate Gel Containing Retinyl Palmitate for Wound Healing. Curr Drug Deliv. 2018;15(8):1172-1182. doi: 10.2174/1567201815666180518123926.

6. Mancuso F, Calvitti M, Milardi D, Grande G, Falabella G, Arato I, Giovagnoli S, Vincenzoni F, Mancini F, Nastruzzi C, Bodo M, Baroni T, Castagnola M, Marana R, Pontecorvi A, Calafiore R, Luca G. Testosterone and FSH modulate Sertoli cell extracellular secretion: Proteomic analysis. Mol Cell Endocrinol. 2018 Nov 15;476:1-7. doi: 10.1016/j.mce.2018.04.001. Epub 2018 Apr 25.

7. Esposito E, Sguizzato M, Bories C, Nastruzzi C, Cortesi R. Production and Characterization of a Clotrimazole Liposphere Gel for Candidiasis Treatment. Polymers (Basel). 2018 Feb 8;10(2). pii: E160. doi: 10.3390/polym10020160.

8. Mancuso F, Arato I, Lilli C, Bellucci C, Bodo M, Calvitti M, Aglietti MC, dell'Omo M, Nastruzzi C, Calafiore R, Luca G, Marinucci L. Acute effects of lead on porcine neonatal Sertoli cells in vitro. Toxicol In Vitro. 2018 Apr;48:45-52. doi: 10.1016/j.tiv.2017.12.013. Epub 2017 Dec 19.

9. Esposito E, Sguizzato M, Drechsler M, Mariani P, Carducci F, Nastruzzi C, Cortesi R. Progesterone lipid nanoparticles: Scaling up and in vivo human study. Eur J Pharm Biopharm. 2017 Oct;119:437-446. doi: 10.1016/j.ejpb.2017.07.015. Epub 2017 Jul 29.

10. Angelozzi M, Penolazzi L, Mazzitelli S, Lambertini E, Lolli A, Piva R, Nastruzzi C. Dedifferentiated Chondrocytes in Composite Microfibers As Tool for Cartilage Repair. Front Bioeng Biotechnol. 2017 Jun 13;5:35. doi: 10.3389/fbioe.2017.00035. eCollection 2017.

 


DOTTORATI DI RICERCA

Componente U.O.

Dottorato di Ricerca

Coordinatore

Sede

Nastruzzi Claudio

Scienze Chimiche

Alberto Cavazzini

Ferrara
Rita Cortesi Scienze Chimiche Alberto Cavazzini Ferrara
Elisabetta Esposito Scienze Chimiche Alberto Cavazzini Ferrara

CONGRESSI C.I.B.

Congressi Partecipazione
CNB4
si
CNB5
si
CNB6
si