Pesole Graziano Stampa
RESPONSABILE DELLA U. O.

Cognome e Nome PESOLE GRAZIANO
Qualifica FULL PROFESSOR
Dipartimento BIOSCIENCES, BIOTECHNOLOGY AND BIOPHARMACEUTICS
Settore Scientifico Disciplinare BIO/11
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PERSONALE STRUTTURATO

Cognome e Nome GISSI CARMELA
Qualifica ASSOCIATE PROFESSOR
Dipartimento BIOSCIENCES, BIOTECHNOLOGY AND BIOPHARMACEUTICS
Ente di appartenenza UNIVERSITY OF BARI “A. MORO”
Cognome e Nome D’ERCHIA ANNA MARIA
Qualifica ASSISTANT PROFESSOR (RUTI)
Dipartimento BIOSCIENCES, BIOTECHNOLOGY AND BIOPHARMACEUTICS
Ente di appartenenza UNIVERSITY OF BARI “A. MORO”
Cognome e Nome
PICARDI ERNESTO
Qualifica
ASSISTANT PROFESSOR (RUTI)
Dipartimento
BIOSCIENCES, BIOTECHNOLOGY AND BIOPHARMACEUTICS
Ente di appartenenza
UNIVERSITY OF BARI “A. MORO”
Cognome e Nome CHIMIENTI GUGLIELMINA
Qualifica ASSISTANT PROFESSOR (RUTI)
Dipartimento BIOSCIENCES, BIOTECHNOLOGY AND BIOPHARMACEUTICS
Ente di appartenenza UNIVERSITY OF BARI “A. MORO”
Cognome e Nome DE VIRGILIO CATERINA
Qualifica ASSISTANT PROFESSOR (RUTI)
Dipartimento BIOSCIENCES, BIOTECHNOLOGY AND BIOPHARMACEUTICS
Ente di appartenenza UNIVERSITY OF BARI “A. MORO”
Cognome e Nome VOLPICELLA MARIATERESA
Qualifica ASSISTANT PROFESSOR (RUTI)
Dipartimento BIOSCIENCES, BIOTECHNOLOGY AND BIOPHARMACEUTICS
Ente di appartenenza UNIVERSITY OF BARI “A. MORO”
Cognome e Nome CECI LUIGI RUGGIERO
Qualifica SENIOR RESEARCHER
Dipartimento INSTITUTE OF BIOMEMBRANES, BIOENERGETICS AND MOLECULAR BIOTECHNOLOGY (IBIOM)
Ente di appartenenza CONSIGLIO NAZIONALE DELLE RICERCHE
Cognome e Nome TULLO APOLLONIA
Qualifica RESEARCHER
Dipartimento INSTITUTE OF BIOMEMBRANES, BIOENERGETICS AND MOLECULAR BIOTECHNOLOGY (IBIOM)
Ente di appartenenza CONSIGLIO NAZIONALE DELLE RICERCHE
Cognome e Nome CARATOZZOLO MARIANO FRANCESCO
Qualifica RESEARCHER
Dipartimento INSTITUTE OF BIOMEMBRANES, BIOENERGETICS AND MOLECULAR BIOTECHNOLOGY (IBIOM)
Ente di appartenenza CONSIGLIO NAZIONALE DELLE RICERCHE
Cognome e Nome PLACIDO ANTONIO
Qualifica RESEARCHER
Dipartimento INSTITUTE OF BIOMEMBRANES, BIOENERGETICS AND MOLECULAR BIOTECHNOLOGY (IBIOM)
Ente di appartenenza CONSIGLIO NAZIONALE DELLE RICERCHE
Cognome e Nome SANTAMARIA MONICA
Qualifica RESEARCHER
Dipartimento INSTITUTE OF BIOMEMBRANES, BIOENERGETICS AND MOLECULAR BIOTECHNOLOGY (IBIOM)
Ente di appartenenza CONSIGLIO NAZIONALE DELLE RICERCHE
Cognome e Nome FOSSO BRUNO
Qualifica RESEARCHER
Dipartimento INSTITUTE OF BIOMEMBRANES, BIOENERGETICS AND MOLECULAR BIOTECHNOLOGY (IBIOM)
Ente di appartenenza CONSIGLIO NAZIONALE DELLE RICERCHE
Cognome e Nome MANZARI CATERINA
Qualifica TECHNICAL ASSISTANT
Dipartimento INSTITUTE OF BIOMEMBRANES, BIOENERGETICS AND MOLECULAR BIOTECHNOLOGY (IBIOM)
Ente di appartenenza CONSIGLIO NAZIONALE DELLE RICERCHE

PERSONALE NON STRUTTURATO

Cognome e Nome LEONI CLAUDIA
Qualifica POST-DOC (ASSEGNISTA DI RICERCA)
Dipartimento BIOSCIENCES, BIOTECHNOLOGY AND BIOPHARMACEUTICS
Ente di appartenenza UNIVERSITY OF BARI “A. MORO”
Cognome e Nome LAVECCHIA ANNA
Qualifica POST-DOC (ASSEGNISTA DI RICERCA)
Dipartimento BIOSCIENCES, BIOTECHNOLOGY AND BIOPHARMACEUTICS
Ente di appartenenza UNIVERSITY OF BARI “A. MORO”
Cognome e Nome DE FAZIO GIUSEPPE
Qualifica PhD STUDENT (DOTTORANDO)
Dipartimento BIOSCIENCES, BIOTECHNOLOGY AND BIOPHARMACEUTICS
Ente di appartenenza UNIVERSITY OF BARI “A. MORO”
Cognome e Nome MARZANO MARINELLA
Qualifica POST-DOC (ASSEGNISTA DI RICERCA)
Dipartimento INSTITUTE OF BIOMEMBRANES, BIOENERGETICS AND MOLECULAR BIOTECHNOLOGY (IBIOM)
Ente di appartenenza CONSIGLIO NAZIONALE DELLE RICERCHE
Cognome e Nome MARZANO FLAVIANA
Qualifica POST-DOC (ASSEGNISTA DI RICERCA)
Dipartimento INSTITUTE OF BIOMEMBRANES, BIOENERGETICS AND MOLECULAR BIOTECHNOLOGY (IBIOM)
Ente di appartenenza CONSIGLIO NAZIONALE DELLE RICERCHE
Cognome e Nome ORANGER ANNARITA
Qualifica POST-DOC (ASSEGNISTA DI RICERCA)
Dipartimento INSTITUTE OF BIOMEMBRANES, BIOENERGETICS AND MOLECULAR BIOTECHNOLOGY (IBIOM)
Ente di appartenenza CONSIGLIO NAZIONALE DELLE RICERCHE
Cognome e Nome DE ROBERTIS MARIANGELA
Qualifica POST-DOC (ASSEGNISTA DI RICERCA)
Dipartimento INSTITUTE OF BIOMEMBRANES, BIOENERGETICS AND MOLECULAR BIOTECHNOLOGY (IBIOM)
Ente di appartenenza CONSIGLIO NAZIONALE DELLE RICERCHE
Cognome e Nome LO GIUDICE CLAUDIO
Qualifica POST-DOC (ASSEGNISTA DI RICERCA)
Dipartimento INSTITUTE OF BIOMEMBRANES, BIOENERGETICS AND MOLECULAR BIOTECHNOLOGY (IBIOM)
Ente di appartenenza CONSIGLIO NAZIONALE DELLE RICERCHE

LINEE DI RICERCA

1) Development of experimental strategies, based on massive sequencing and other molecular biology approaches, for genomic sequencing, analysis of the transcriptional profile, alternative splicing pattern, RNA editing and other epigenetic features.

2) Development of bioinformatics methodologies and specialized databases for the analysis and functional characterization of "omics" data. In particular, bioinformatics methodologies include: i) assembly and annotation of viral, prokaryotic and eukaryotic genomes; ii) study of the transcriptome in prokaryotes and eukaryotes and of the alternative splicing pattern of eukaryotic genes; iii) identification and functional characterization of RNA editing events; iv) epigenetic analysis; v) evolution and functional characterization of the mitochondrial genome; vi) taxonomic and functional characterization of the microbiome.

3) Identification of biomarkers and characterization of specific molecular processes in aging, neurodegenerative diseases and tumors;

4) Study of the microbiome in clinical and environmental samples using metagenomic approaches.

 

5) Strategies of "bioremediation" from heavy metals through the identification in the bacterium R. sphaeroides, of the genes involved in the phenomena of resistance / tolerance to high concentrations of heavy metals in the growth environment.

6) Characterization of corn proteins identified as a cause of food allergies. The study will provide the information necessary for subsequent applications in the diagnostic and therapeutic field of these proteins.


7) Pathophysiological lipoprotein proteins, in particular LDL-like lipoprotein Lp (a) as a risk factor for cardiovascular and neuronal diseases.

8) Study of genetic polymorphisms, protein isoforms and their possible interactions with changes in dietary habits in the etiology of acute or chronic inflammatory diseases of the nervous, gastrointestinal and vascular systems.


TECNOLOGIE IN POSSESSO DELL'U. O.

  • Protein cloning, expression and analysis
  • Real time and Digital PCR
  • Genome walking
  • Phage display
  • Bioinformatics
  • Comparative Genomics and Molecular Evolution
  • Next Generation Sequencing
  • Genome editing
  • Molecular Databases
  • Integrative Omics

STRUMENTAZIONE

Denominazione
Struttura ove la strumentazione è allocata
Responsabile della strumentazione
Illumina Next 500
BIOSCIENCES, BIOTECHNOLOGY AND BIOPHARMACEUTICS
Prof. Pesole
Liquid Handling Hamilton for NGS BIOSCIENCES, BIOTECHNOLOGY AND BIOPHARMACEUTICS Prof. Pesole
Droplet Real Time PCR BIOSCIENCES, BIOTECHNOLOGY AND BIOPHARMACEUTICS Prof. Pesole
Agilent Tapestation BIOSCIENCES, BIOTECHNOLOGY AND BIOPHARMACEUTICS Prof. Pesole
Illumina MiSeq INSTITUTE OF BIOMEMBRANES, BIOENERGETICS AND MOLECULAR BIOTECHNOLOGY (IBIOM) Prof. Pesole
MiniION Oxford Nanopore INSTITUTE OF BIOMEMBRANES, BIOENERGETICS AND MOLECULAR BIOTECHNOLOGY (IBIOM) Prof. Pesole

PUBBLICAZIONI

1. Mezzapesa A, Orset C, Plawinski L, Doeuvre L, Martinez de Lizarrondo S,

Chimienti G, Vivien D, Mansour A, Matà S, Pepe G, Anglés-Cano E. Plasminogen in

cerebrospinal fluid originates from circulating blood. J Neuroinflammation. 2014

Sep 16;11:154. doi: 10.1186/s12974-014-0154-y. PubMed PMID: 25220760; PubMed

Central PMCID: PMC4173110 (settore: Immunology; Q1).

 

2. Volpicella M, Leoni C, Fanizza I, Rinalducci S, Placido A, Ceci LR. Expression

and characterization of a new isoform of the 9 kDa allergenic lipid transfer

protein from tomato (variety San Marzano). Plant Physiol Biochem. 2015

Nov;96:64-71. doi: 10.1016/j.plaphy.2015.07.019. Epub 2015 Jul 21. PubMed PMID:

26232648 (settore: Plant Sciences; Q1).

 

3. Chiara M, Fanelli F, Mulè G, Logrieco AF, Pesole G, Leslie JF, Horner DS,

Toomajian C. Genome sequencing of multiple isolates highlights sub-telomeric

genomic diversity within Fusarium fujikuroi. Genome Biol Evol. 2015 Oct 15. pii:

evv198. [Epub ahead of print] PubMed PMID: 26475319. (settore: Genetics & Heredity; Q1)

 

4. Fransen F, Zagato E, Mazzini E, Fosso B, Manzari C, El Aidy S, Chiavelli A,

D'Erchia AM, Sethi MK, Pabst O, Marzano M, Moretti S, Romani L, Penna G, Pesole

G, Rescigno M. BALB/c and C57BL/6 Mice Differ in Polyreactive IgA Abundance,

which Impacts the Generation of Antigen-Specific IgA and Microbiota Diversity.

Immunity. 2015 Sep 15;43(3):527-40. doi: 10.1016/j.immuni.2015.08.011. Epub 2015

Sep 8. PubMed PMID: 26362264. (settore: Immunology; Q1)

 

5. Placido A, Hai T, Ferrer M, Chernikova TN, Distaso M, Armstrong D, Yakunin AF,

Toshchakov SV, Yakimov MM, Kublanov IV, Golyshina OV, Pesole G, Ceci LR, Golyshin

PN. Diversity of hydrolases from hydrothermal vent sediments of the Levante Bay,

Vulcano Island (Aeolian archipelago) identified by activity-based metagenomics

and biochemical characterization of new esterases and an arabinopyranosidase.

Appl Microbiol Biotechnol. 2015 Dec;99(23):10031-46. doi:10.1007/s00253-015-6873-x. Epub 2015 Aug 13. PubMed PMID: 26266751; PubMed Central PMCID: PMC4643112. (settore: Applied Microbiology and Biotechnology; Q1)

 

 

6. Chiara M, Caruso M, D'Erchia AM, Manzari C, Fraccalvieri R, Goffredo E,

Latorre L, Miccolupo A, Padalino I, Santagada G, Chiocco D, Pesole G, Horner DS,

Parisi A. Comparative Genomics of Listeria Sensu Lato: Genus-Wide Differences in

Evolutionary Dynamics and the Progressive Gain of Complex, Potentially

Pathogenicity-Related Traits through Lateral Gene Transfer. Genome Biol Evol.

2015 Jul 15;7(8):2154-72. doi: 10.1093/gbe/evv131. PubMed PMID: 26185097; PubMed

Central PMCID: PMC4558849. (settore: Genetics & Heredity; Q1)

 

7. Giulietti M, Piva F, D'Antonio M, D'Onorio De Meo P, Paoletti D, Castrignanò

T, D'Erchia AM, Picardi E, Zambelli F, Principato G, Pavesi G, Pesole G.

SpliceAid-F: a database of human splicing factors and their RNA-binding sites.

Nucleic Acids Res. 2013 Jan;41(Database issue):D125-31. doi: 10.1093/nar/gks997.

Epub 2012 Oct 30. PubMed PMID: 23118479; PubMed Central PMCID: PMC3531144. (settore: Biochemistry and Molecular Biology; Q1)

 

8. Santamaria M, Fosso B, Consiglio A, De Caro G, Grillo G, Licciulli F, Liuni S, Marzano M, Alonso-Alemany D, Valiente G, Pesole G. Reference databases for taxonomic assignment in metagenomics. Brief Bioinform. 2012 Nov;13(6):682-95. doi: 10.1093/bib/bbs036. Epub 2012 Jul 10. Review. PubMed PMID: 22786784. (settore: Biochemical Research Methods; Q1)

 

9. D'Erchia AM, Atlante A, Gadaleta G, Pavesi G, Chiara M, De Virgilio C, Manzari

C, Mastropasqua F, Prazzoli GM, Picardi E, Gissi C, Horner D, Reyes A, Sbisà E,

Tullo A, Pesole G. Tissue-specific mtDNA abundance from exome data and its

correlation with mitochondrial transcription, mass and respiratory activity.

Mitochondrion. 2015 Jan;20:13-21. doi: 10.1016/j.mito.2014.10.005. Epub 2014 Nov

1. PubMed PMID: 25446395. (settore: Biochemistry and Molecular Biology; Q1)

 

10. Picardi E, Pesole G. Mitochondrial genomes gleaned from human whole-exome

sequencing. Nat Methods. 2012 May 30;9(6):523-4. doi: 10.1038/nmeth.2029. PubMed

PMID: 22669646.(settore: Biochemical Research Methods; Q1)


DOTTORATI DI RICERCA

Componente U.O. Dottorato di Ricerca Coordinatore Sede
PESOLE GRAZIANO
GENOMICA E PROTEOMICA FUNZIONALE E APPLICATA
VALENTI IVANA
Bari
GISSI CARMELA GENOMICA E PROTEOMICA FUNZIONALE E APPLICATA VALENTI IVANA Bari
D’ERCHIA ANNA MARIA GENOMICA E PROTEOMICA FUNZIONALE E APPLICATA VALENTI IVANA Bari
PICARDI ERNESTO GENOMICA E PROTEOMICA FUNZIONALE E APPLICATA VALENTI IVANA Bari
TULLO APOLLONIA GENOMICA E PROTEOMICA FUNZIONALE E APPLICATA VALENTI IVANA Bari

CONGRESSI C.I.B.

Congressi Partecipazione
CNB3
SI
CNB2
SI
CNB9 SI
CNB10 SI
CNB11 SI