Direzione e uffici C.I.B.

Direzione CIB:
Prof. Claudio Schneider
Email: claudio.schneider@Lncib.it

Segreteria CIB:
Prof. Roberto Gambari
Email: roberto.gambari@unife.it

SEGRETERIA ORGANIZZATIVA:
Elisabetta Lambertini
Tel: 0532/974451
Fax: 0532/974484
E-mail: lmblbt@unife.it

AMMINISTRAZIONE:
Vanessa Florit
Area di Ricerca
Padriciano, 99 - 34012 Trieste
Tel: 040/398979
Fax: 040/398990
E-mail: cib@lncib.it

Posta certificata C.I.B.:
cib@poste-certificate.it

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Medici Alessandro Stampa
RESPONSABILE DELLA U. O.

Cognome e Nome
Medici Alessandro
Qualifica
PO
Facoltà
Ingegneria
Dipartimento Risorse naturali e culturali UNIFE
Settore Scientifico Disciplinare CHIM/06
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PERSONALE STRUTTURATO

Cognome e Nome GIOVANNINI Pier Paolo
Qualifica tecnico
Dipartimento Risorse naturali e culturali
Ente di appartenenza
Università di Ferrara
Cognome e Nome PEDRINI Paola
Qualifica
PA
Dipartimento Risorse naturali e culturali
Ente di appartenenza
Università di Ferrara
Cognome e Nome
SACCHETTI Gianni
Qualifica
PA
Dipartimento Risorse naturali e culturali
Ente di appartenenza
Università di Ferrara
Cognome e Nome
Qualifica
Dipartimento
Ente di appartenenza
Cognome e Nome
Qualifica
Dipartimento
Ente di appartenenza
Cognome e Nome
Qualifica
Dipartimento
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PERSONALE NON STRUTTURATO

Cognome e Nome
MAIETTI Silvia
Qualifica Assegnista
Dipartimento
Risorse naturali e culturali
Ente di appartenenza
Università di Ferrara
Cognome e Nome
MANTOVANI Matteo
Qualifica
Dottorando
Dipartimento
Risorse naturali e culturali
Ente di appartenenza
Università di Ferrara
Cognome e Nome
Qualifica
Dipartimento
Ente di appartenenza
Cognome e Nome
Qualifica
Dipartimento
Ente di appartenenza
Cognome e Nome
Qualifica
Dipartimento
Ente di appartenenza
Cognome e Nome
Qualifica
Dipartimento
Ente di appartenenza

LINEE DI RICERCA

The synthesis of enantiomerically pure compounds is a more and more interesting research field by applicatory point of view regarding the production of pharmaceuticals and agrochemicals compounds, as pesticides, fungicides and herbicides, and flavouring compounds for food industry. A very significant datum concerns the world market of chiral derivatives that, in 1996, was about 73 thousand million dollars and that, in 2000, is increased to 90 thousands million dollars. As a consequence, the development of efficient processes, but, in the meantime, acceptable for the environment, for the synthesis of optically active compounds is essential and represents the most important challenge of the organic synthesis. Our research line concerns the synthesis of optically active molecules in mild and controlled conditions using biocalysts. The studied reactions are the redox reactions mediated by alcohol dehydrogenase of bacteria, moulds and vegetable cells of upper plants. Bacteria and moulds are also used in oxidation of ketones to esters (Baeyer-Villiger reaction), in particular utilizing bicyclic ketones as synthetic intermediates to obtain prostaglandins and prostacyclins, and in the oxidation of sulfides to sulfoxides. Endophite fungi, coming from different habitats, and plant cells are also utilized for the synthesis of enantiomerically enriched secondary alcohols and lactams by biotransformation of exogenous substrates. These are prochiral ketones or racemic alcohols if redox bioprocesses are present and racemic esters or lactams for hydrolytic bioprocesses. The choice of vegetables as substrate for biotransformation will fall on plants with agronomic interest and on undifferentiated, stabilized in vitro, plant cultured cells.

TECNOLOGIE IN POSSESSO DELL'U. O.

  • Isolation and characterization of microrganisms
  • Biocatalyzed redox reactions
  • Metabolic fingerprint of microrganisms

STRUMENTAZIONE

Denominazione
Struttura ove la strumentazione è allocata
Responsabile della strumentazione
HPLC
Dip. Risorse naturali e culturali
Medici
GC-Mass spectrometry
Dip. Risorse naturali e culturali
Medici
NMR spectrometry
Dip. Chimica
Dondoni
GC
Dip. Risorse naturali e culturali
Medici
Fermenter
Dip. Risorse naturali e culturali
Medici

PUBBLICAZIONI

G. FANTIN, M. FOGAGNOLO, A. MEDICI, P. PEDRINI, S. FONTANA – Kinetic resolution of racemic secondary alcohols via oxidation with Yarrowia lipolytica strains. Tetrahedron Asymm. 11, 2367, 2000 (Chemisty, Organic, 20/53, 2.163).

MUZZOLI M., SACCHETTI G. - Biological activity of four thiophene compounds in resting Saccharomyces cerevisiae cells. Pharmacetical Biology. 39, 40-42, 2001 (Pharmacology & Pharmacy, 180/188, 0.262).

BRUNI R., FANTIN G., MEDICI A., PEDRINI P., SACCHETTI G. - Plants in organic synthesis: an alternative to baker's yeast. Tetrahedron Letters. 43: 3377-3379, 2002 (Chemistry Organic, 14/53, 2.357).

MEDICI A., PEDRINI P., BIANCHINI E., FANTIN G., GUERRINI A., NATALINI B. AND PELLICCIARI R. – 7α-OH Epimerization of bile acids via oxido-reduction with Xanthomonas maltophilia. Steroids, 67, 51, 2002 (Biochemistry, Molecular Biology 110/266, 2.524).

O. BORTOLINI, G. FANTIN, M. FOGAGNOLO, R. FORLANI, S. MAIETTI, P. PEDRINI – Improved enantioselectivity in the epoxidation of cinnamic acid derivatives with dioxiranes from keto bile acids. J. Org. Chem. 67, 5802 (2002).

R. BRUNI, A. MEDICI, E. ANDREOTTI, G. FANTIN, M. MUZZOLI, M. DEHESA, C. ROMAGNOLI, G. SACCHETTI - Chemical Composition and Biological Activities of Ishpingo Essential Oil, a Traditional Ecuadorian Spice from Ocotea quixos (Lam.) Kosterm. (Lauraceae) flower calices. Food Chemistry, 85, 415-421 (2004) (Food & Science Technology, 15/92, 1.396).

G. SACCHETTI, S. MAIETTI, M. MUZZOLI, M. SCAGLIANTI, S. MANFREDINI, M. RADICE, R. BRUNI - Comparative evaluation of 11 essential oils of different origin as functional antioxidants, antiradicals and antimicrobials in foods. Food Chemistry, 91: 621-632, 2005.

R. BRUNI, G. SACCHETTI Microorganism – plant interactions as influencers of medicinal plants secondary metabolism. Minerva Biotecnologica; 17(3): 119-125, 2005.

F. CONFORTI, G. STATTI, M.R. LOIZZO, G. SACCHETTI, F. POLI, F. MENICHINI - In Vitro Antioxidant and Antidiabetic Effects of two Varieties of Amaranthus caudatus seeds. Biological & Pharmaceutical Bulletin, 28:1098-1102, 2005. (IF 1,124 Pharmacology and Pharmacy).

P. PEDRINI, E. ANDREOTTI, M. DEAN, G. FANTIN, P.P. GIOVANNINI, A. GUERRINI – Xanthomonas maltophilia CBS 897.97 as a source of new 7- and 7-hydroxysteroid dehydrogenases and cholylglycine hydrolase: improved biotransformations of bile acids. Steroids, 71,189-198 (2006).

DOTTORATI DI RICERCA

Componente U.O. Dottorato di Ricerca Coordinatore Sede
Medici Alessandro
Biologia cellulare e delle strutture sopramolecolari
Grazi
Ferrara
Pedrini Paola
Biologia cellulare e delle strutture sopramolecolari
Grazi
Ferrara
Sacchetti Gianni
Biologia cellulare e delle strutture sopramolecolari
Grazi
Ferrara

CONGRESSI C.I.B.

Congressi Partecipazione
CNB4

CNB5

CNB6

CNB7

CNB8

CNB9
CNB10