Direzione e uffici C.I.B.

Direzione CIB:
Prof. Claudio Schneider
Email: claudio.schneider@Lncib.it

Segreteria CIB:
Prof. Roberto Gambari
Email: roberto.gambari@unife.it

SEGRETERIA ORGANIZZATIVA:
Elisabetta Lambertini
Tel: 0532/974451
Fax: 0532/974484
E-mail: lmblbt@unife.it

AMMINISTRAZIONE:
Vanessa Florit
Area di Ricerca
Padriciano, 99 - 34012 Trieste
Tel: 040/398979
Fax: 040/398990
E-mail: cib@lncib.it

Posta certificata C.I.B.:
cib@poste-certificate.it

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Duatti Adriano Stampa
RESPONSABILE DELLA U. O.

Cognome e Nome Duatti Adriano
Qualifica
Associate Professor
Facoltà Engineering
Dipartimento SA & Radiological Sciences
Settore Scientifico Disciplinare CHIM/03
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PERSONALE STRUTTURATO

Cognome e Nome Boschi Alessandra
Qualifica Research Assistant
Dipartimento SA & Radiological Sciences
Ente di appartenenza
University of Ferrara
Cognome e Nome Cittanti Corrado
Qualifica
Senior Researcher
Dipartimento SA & Radiological Sciences
Ente di appartenenza
University of Ferrara
Cognome e Nome Giganti Melchiore
Qualifica
Associate Professor
Dipartimento SA & Radiological Sciences
Ente di appartenenza
University of Ferrara
Cognome e Nome
Rossin Rodolfo
Qualifica TSRM
Dipartimento SA & Radiological Sciences
Ente di appartenenza
University of Ferrara
Cognome e Nome Uccelli Licia
Qualifica
Senior Researcher
Dipartimento SA & Radiological Sciences
Ente di appartenenza
University of Ferrara
Cognome e Nome
Qualifica
Dipartimento
Ente di appartenenza

PERSONALE NON STRUTTURATO

Cognome e Nome Pasquali Micol
Qualifica Ph. D.
Dipartimento SA & Radiological Sciences
Ente di appartenenza University of Ferrara
Cognome e Nome
Qualifica
Dipartimento
Ente di appartenenza
Cognome e Nome
Qualifica
Dipartimento
Ente di appartenenza
Cognome e Nome
Qualifica
Dipartimento
Ente di appartenenza
Cognome e Nome
Qualifica
Dipartimento
Ente di appartenenza
Cognome e Nome
Qualifica
Dipartimento
Ente di appartenenza

LINEE DI RICERCA

Molecular imaging is an emerging field of study that deals with imaging of disease on a molecular and functional level rather than on a macroscopic level. The ability to noninvasively monitor cell biology in vivo is the goal of molecular imaging, which is progressively becoming a fundamental tool for exploring the behaviour of biomolecular interactions when entangled in a living tissue with other processes to form an interacting biological network. Tremendous advances in molecular biology have revealed the sequence, structure, and function of genes and proteins, the physicochemical properties of cellular ligands and receptors, and crucial details about the cell cycle and genetic mutations. These discoveries have led to an increased understanding of the fundamental mechanisms of disease and to the development of biomolecular based therapies. Research in biologic sciences combined with exploration in radiologic sciences could allow to image the molecular basis of disease, to image responses to therapy on a molecular level, and to evaluate the effectiveness of a specific therapeutic approach noninvasively. Single-Photon Emission-Computed Tomography (SPECT) and Positron Emission Tomography (PET) are external imaging techniques with high sensitivity and resolution that is best suited for monitoring biochemical reactions in vivo on integrated living systems. Though new, highly sensitive in vivo investigations, such as magnetic resonance imaging and spiral computed tomography, are able to locate relatively small focal abnormalities, however, these methods basically rely on the detection of morphological changes. Therefore, they are unable to discriminate active processes from anatomic changes. Radiopharmaceuticals are single radiolabeled molecules that accumulate in the target area as a result of local physiochemical changes. Thus, they act as molecular probes interacting with subcellular structures or specific biomolecular processes. It turns out that, since scintigraphic images do not depend on morphological alterations, they may provide information on biological pathways at the deepest molecular level, but without perturbing those biochemical networks always operating in a living integrated system.

TECNOLOGIE IN POSSESSO DELL'U. O.

  • SPECT (Single Photon Emission Computed Tomography)
  • PET (Positron Emission Tomography)
  • Molecular Imaging
  • Labeling of Biomolecules
  • Chromatography

STRUMENTAZIONE

Denominazione
Struttura ove la strumentazione è allocata
Responsabile della strumentazione
YAP(S)PET Small-animal Scanner
Dept. of SA & Radiological Sciences
A. Duatti
HPLC
Dept. of SA & Radiological Sciences
A. Duatti
Cyclone Imager Scanner
Dept. of SA & Radiological Sciences
A. Duatti

PUBBLICAZIONI

A. Boschi, A. Duatti, L. Uccelli Development of Technetium-99m and Rhenium-188 Radiopharmaceuticals Containing a Terminal Metal–Nitrido Multiple Bond for Diagnosis and Therapy Topics in Current Chemistry 2005 (252): 85-101.

Tisato F, Refosco F, Porchia M, Bolzati C, Bandoli G, Dolmella A, Duatti A, Boschi A, Jung CM, Pietzsch HJ, Kraus W. The crucial role of the diphosphine heteroatom X in the stereochemistry and stabilization of the substitution-inert [M(N)(PXP)]2+ metal fragments (M = Tc, Re; PXP = diphosphine ligand). Inorg Chem. 2004 Dec 27;43(26):8617-25.

Hatada K, Riou LM, Ruiz M, Yamamichi Y, Duatti A, Lima RL, Goode AR, Watson DD, Beller GA, Glover DK. 99mTc-N-DBODC5, a new myocardial perfusion imaging agent with rapid liver clearance: comparison with 99mTc-sestamibi and 99mTc-tetrofosmin in rats. J Nucl Med. 2004 Dec;45(12):2095-101.

Duatti A. In vivo imaging of oligonucleotides with nuclear tomography. Curr Drug Targets. 2004 Nov;5(8):753-60. Review.

Boschi A, Uccelli L, Duatti A, Colamussi P, Cittanti C, Filice A, Rose AH, Martindale AA, Claringbold PG, Kearney D, Galeotti R, Turner JH, Giganti M. A kit formulation for the preparation of 188Re-lipiodol: preclinical studies and preliminary therapeutic evaluation in patients with unresectable hepatocellular carcinoma. Nucl Med Commun. 2004 Jul;25(7):691-9. Erratum in: Nucl Med Commun. 2004 Sep;25(9):983. Claringbold, Paul G [corrected to Claringbold, Phillip G]; Turner, Harvey J [corrected to Turner, J Harvey].

Bolzati C, Benini E, Cazzola E, Jung C, Tisato F, Refosco F, Pietzsch HJ, Spies H, Uccelli L, Duatti A. Synthesis, characterization, and biological evaluation of neutral nitrido technetium(V) mixed ligand complexes containing dithiolates and aminodiphosphines. A novel system for linking technetium to biomolecules. Bioconjug Chem. 2004 May-Jun;15(3):628-37.

Boschi A, Uccelli L, Duatti A, Bolzati C, Refosco F, Tisato F, Romagnoli R, Baraldi PG, Varani K, Borea PA. Asymmetrical nitrido tc-99m heterocomplexes as potential imaging agents for benzodiazepine receptors. Bioconjug Chem. 2003 Nov-Dec;14(6):1279-88.

Bolzati C, Mahmood A, Malago E, Uccelli L, Boschi A, Jones AG, Refosco F, Duatti A, Tisato F. The [(99m)Tc(N)(PNP)](2+) metal fragment: a technetium-nitrido synthon for use with biologically active molecules. The N-(2-methoxyphenyl)piperazyl-cysteine analogues as examples. Bioconjug Chem. 2003 Nov-Dec;14(6):1231-42.

Boschi A, Bolzati C, Uccelli L, Duatti A. High-yield synthesis of the terminal 188Re triple bond N multiple bond from generator-produced [188ReO4](-). Nucl Med Biol. 2003 May;30(4):381-7.

Boschi A, Uccelli L, Bolzati C, Duatti A, Sabba N, Moretti E, Di Domenico G, Zavattini G, Refosco F, Giganti M. Synthesis and biologic evaluation of monocationic asymmetric 99mTc-nitride heterocomplexes showing high heart uptake and improved imaging properties. J Nucl Med. 2003 May;44(5):806-14.

DOTTORATI DI RICERCA

Componente U.O. Dottorato di Ricerca Coordinatore Sede
Adriano Duatti
Biochemistry, Molecular Biology, Biotechnology
Roberto Gambari
Dept. of Biotechnology

CONGRESSI C.I.B.

Congressi Partecipazione
CNB4

CNB5

CNB6

CNB7

CNB8

CNB9
CNB10