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RESPONSABILE DELLA U. O. |
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Cognome e Nome |
Duatti Adriano |
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Qualifica |
Associate Professor
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Facoltà |
Engineering |
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Dipartimento |
SA & Radiological Sciences |
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Settore Scientifico Disciplinare |
CHIM/03 |
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E-mail |
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PERSONALE STRUTTURATO |
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Cognome e Nome |
Boschi Alessandra |
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Qualifica |
Research Assistant |
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Dipartimento |
SA & Radiological Sciences |
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Ente di appartenenza |
University of Ferrara
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Cognome e Nome |
Cittanti Corrado |
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Qualifica |
Senior Researcher
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Dipartimento |
SA & Radiological Sciences |
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Ente di appartenenza |
University of Ferrara
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Cognome e Nome |
Giganti Melchiore |
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Qualifica |
Associate Professor
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Dipartimento |
SA & Radiological Sciences |
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Ente di appartenenza |
University of Ferrara
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Cognome e Nome |
Rossin Rodolfo
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Qualifica |
TSRM |
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Dipartimento |
SA & Radiological Sciences |
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Ente di appartenenza |
University of Ferrara
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Cognome e Nome |
Uccelli Licia |
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Qualifica |
Senior Researcher
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Dipartimento |
SA & Radiological Sciences |
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Ente di appartenenza |
University of Ferrara
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PERSONALE NON STRUTTURATO |
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Cognome e Nome |
Pasquali Micol |
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Qualifica |
Ph. D. |
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Dipartimento |
SA & Radiological Sciences |
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Ente di appartenenza |
University of Ferrara |
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LINEE DI RICERCA |
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Molecular imaging is an emerging field of study that deals with imaging of disease on a molecular and functional level rather than on a macroscopic level. The ability to noninvasively monitor cell biology in vivo is the goal of molecular imaging, which is progressively becoming a fundamental tool for exploring the behaviour of biomolecular interactions when entangled in a living tissue with other processes to form an interacting biological network. Tremendous advances in molecular biology have revealed the sequence, structure, and function of genes and proteins, the physicochemical properties of cellular ligands and receptors, and crucial details about the cell cycle and genetic mutations. These discoveries have led to an increased understanding of the fundamental mechanisms of disease and to the development of biomolecular based therapies. Research in biologic sciences combined with exploration in radiologic sciences could allow to image the molecular basis of disease, to image responses to therapy on a molecular level, and to evaluate the effectiveness of a specific therapeutic approach noninvasively. Single-Photon Emission-Computed Tomography (SPECT) and Positron Emission Tomography (PET) are external imaging techniques with high sensitivity and resolution that is best suited for monitoring biochemical reactions in vivo on integrated living systems. Though new, highly sensitive in vivo investigations, such as magnetic resonance imaging and spiral computed tomography, are able to locate relatively small focal abnormalities, however, these methods basically rely on the detection of morphological changes. Therefore, they are unable to discriminate active processes from anatomic changes. Radiopharmaceuticals are single radiolabeled molecules that accumulate in the target area as a result of local physiochemical changes. Thus, they act as molecular probes interacting with subcellular structures or specific biomolecular processes. It turns out that, since scintigraphic images do not depend on morphological alterations, they may provide information on biological pathways at the deepest molecular level, but without perturbing those biochemical networks always operating in a living integrated system. |
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TECNOLOGIE IN POSSESSO DELL'U. O. |
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- SPECT (Single Photon Emission Computed Tomography)
- PET (Positron Emission Tomography)
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STRUMENTAZIONE |
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Denominazione
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Struttura ove la strumentazione è allocata
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Responsabile della strumentazione
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YAP(S)PET Small-animal Scanner
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Dept. of SA & Radiological Sciences
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A. Duatti
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HPLC
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Dept. of SA & Radiological Sciences
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A. Duatti
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Cyclone Imager Scanner
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Dept. of SA & Radiological Sciences
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A. Duatti
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PUBBLICAZIONI |
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A. Boschi, A. Duatti, L. Uccelli Development of Technetium-99m and Rhenium-188 Radiopharmaceuticals Containing a Terminal Metal–Nitrido Multiple Bond for Diagnosis and Therapy Topics in Current Chemistry 2005 (252): 85-101.
Tisato F, Refosco F, Porchia M, Bolzati C, Bandoli G, Dolmella A, Duatti A, Boschi A, Jung CM, Pietzsch HJ, Kraus W. The crucial role of the diphosphine heteroatom X in the stereochemistry and stabilization of the substitution-inert [M(N)(PXP)]2+ metal fragments (M = Tc, Re; PXP = diphosphine ligand). Inorg Chem. 2004 Dec 27;43(26):8617-25.
Hatada K, Riou LM, Ruiz M, Yamamichi Y, Duatti A, Lima RL, Goode AR, Watson DD, Beller GA, Glover DK. 99mTc-N-DBODC5, a new myocardial perfusion imaging agent with rapid liver clearance: comparison with 99mTc-sestamibi and 99mTc-tetrofosmin in rats. J Nucl Med. 2004 Dec;45(12):2095-101.
Duatti A. In vivo imaging of oligonucleotides with nuclear tomography. Curr Drug Targets. 2004 Nov;5(8):753-60. Review.
Boschi A, Uccelli L, Duatti A, Colamussi P, Cittanti C, Filice A, Rose AH, Martindale AA, Claringbold PG, Kearney D, Galeotti R, Turner JH, Giganti M. A kit formulation for the preparation of 188Re-lipiodol: preclinical studies and preliminary therapeutic evaluation in patients with unresectable hepatocellular carcinoma. Nucl Med Commun. 2004 Jul;25(7):691-9. Erratum in: Nucl Med Commun. 2004 Sep;25(9):983. Claringbold, Paul G [corrected to Claringbold, Phillip G]; Turner, Harvey J [corrected to Turner, J Harvey].
Bolzati C, Benini E, Cazzola E, Jung C, Tisato F, Refosco F, Pietzsch HJ, Spies H, Uccelli L, Duatti A. Synthesis, characterization, and biological evaluation of neutral nitrido technetium(V) mixed ligand complexes containing dithiolates and aminodiphosphines. A novel system for linking technetium to biomolecules. Bioconjug Chem. 2004 May-Jun;15(3):628-37.
Boschi A, Uccelli L, Duatti A, Bolzati C, Refosco F, Tisato F, Romagnoli R, Baraldi PG, Varani K, Borea PA. Asymmetrical nitrido tc-99m heterocomplexes as potential imaging agents for benzodiazepine receptors. Bioconjug Chem. 2003 Nov-Dec;14(6):1279-88.
Bolzati C, Mahmood A, Malago E, Uccelli L, Boschi A, Jones AG, Refosco F, Duatti A, Tisato F. The [(99m)Tc(N)(PNP)](2+) metal fragment: a technetium-nitrido synthon for use with biologically active molecules. The N-(2-methoxyphenyl)piperazyl-cysteine analogues as examples. Bioconjug Chem. 2003 Nov-Dec;14(6):1231-42.
Boschi A, Bolzati C, Uccelli L, Duatti A. High-yield synthesis of the terminal 188Re triple bond N multiple bond from generator-produced [188ReO4](-). Nucl Med Biol. 2003 May;30(4):381-7.
Boschi A, Uccelli L, Bolzati C, Duatti A, Sabba N, Moretti E, Di Domenico G, Zavattini G, Refosco F, Giganti M. Synthesis and biologic evaluation of monocationic asymmetric 99mTc-nitride heterocomplexes showing high heart uptake and improved imaging properties. J Nucl Med. 2003 May;44(5):806-14.
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DOTTORATI DI RICERCA |
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| Componente U.O. |
Dottorato di Ricerca |
Coordinatore |
Sede |
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Adriano Duatti
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Biochemistry, Molecular Biology, Biotechnology
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Roberto Gambari
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Dept. of Biotechnology
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CONGRESSI C.I.B. |
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| Congressi |
Partecipazione |
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CNB4
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CNB5
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CNB6
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CNB7
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CNB8
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Consorzio (sedi e unità operative) 