Direzione e uffici C.I.B.

Direzione CIB:
Prof. Claudio Schneider
Email: claudio.schneider@Lncib.it

Segreteria CIB:
Prof. Roberto Gambari
Email: roberto.gambari@unife.it

SEGRETERIA ORGANIZZATIVA:
Elisabetta Lambertini
Tel: 0532/974451
Fax: 0532/974484
E-mail: lmblbt@unife.it

AMMINISTRAZIONE:
Vanessa Florit
Area di Ricerca
Padriciano, 99 - 34012 Trieste
Tel: 040/398979
Fax: 040/398990
E-mail: cib@lncib.it

Posta certificata C.I.B.:
cib@poste-certificate.it

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Ciani Elisabetta Stampa

RESPONSABILE DELLA U. O.

Cognome e Nome Ciani Elisabetta
Qualifica Associate Professor
Dipartimento Department of Biomedical and Neuromotor Sciences, University of Bologna
Settore Scientifico Disciplinare BIO/09 FISIOLOGIA
E-mail Questo indirizzo e-mail è protetto dallo spam bot. Abilita Javascript per vederlo.
tel 0512091773

PERSONALE STRUTTURATO

Cognome e Nome Guidi Sandra
Qualifica Assistant Professor (RTI)
Dipartimento Department of Biomedical and Neuromotor Sciences
Ente di appartenenza University of Bologna
Cognome e Nome Trazzi Stefania
Qualifica Assistant Professor (RTI)
Dipartimento Department of Biomedical and Neuromotor Sciences
Ente di appartenenza University of Bologna

PERSONALE NON STRUTTURATO

Cognome e Nome Fuchs Claudia
Qualifica Postdoc
Dipartimento Department of Biomedical and Neuromotor Sciences
Ente di appartenenza University of Bologna
Cognome e Nome Stagni Fiorenza
Qualifica Post-Doc
Dipartimento Department of Biomedical and Neuromotor Sciences
Ente di appartenenza University of Bologna
Cognome e Nome Gennaccaro Laura
Qualifica Post-Doc
Dipartimento Department of Biomedical and Neuromotor Sciences
Ente di appartenenza University of Bologna
Cognome e Nome Giacomini Andrea
Qualifica Post-Doc
Dipartimento Department of Biomedical and Neuromotor Sciences
Ente di appartenenza University of Bologna
Cognome e Nome Ren Elisa
Qualifica Post-Doc
Dipartimento Department of Biomedical and Neuromotor Sciences
Ente di appartenenza University of Bologna
Cognome e Nome Emili Marco
Qualifica PhD student
Dipartimento Department of Biomedical and Neuromotor Sciences
Ente di appartenenza University of Bologna
Cognome e Nome Medici Giorgio
Qualifica PhD student
Dipartimento Department of Biomedical and Neuromotor Sciences
Ente di appartenenza University of Bologna
Cognome e Nome Uguagliati Beatrice
Qualifica PhD student
Dipartimento Department of Biomedical and Neuromotor Sciences
Ente di appartenenza University of Bologna

LINEE DI RICERCA

The main research lines concern the identification of therapies able to improve the severe cognitive disability that characterizes two neurodevelopmental disorders: CDKL5 disorder and Down Syndrome (DS).

CDKL5 disorder is a rare, severe neurodevelopmental disorder that mostly affects girls. CDKL5 patients show a range of phenotypes including seizures, visual impairment, mental retardation and autism. Currently, there is no cure or effective treatment for CDKL5 disorder, and the mainstay of care for this disorder is support for the families. Therefore, identification of therapies for CDKL5 disorder will represent an important social challenge.

The goal of this project is to identify therapies for CDKL5 disorder. Precisely, we aim to develop and evaluate the efficacy of therapeutic approaches targeting molecules affected by CDKL5 mutations in a Cdkl5 knockout mouse model. Treatment options will range from pharmacological drug therapies, to gene therapy, to an innovative “protein substitution therapy" that compensates for CDKL5 deficiency through administration of a recombinant protein produced in the laboratory. Ours preliminary results, suggest that a CDKL5 protein therapy could be indeed an effective therapeutic approach. Altogether, we deem that the approaches used in this project shall ensure achievement of substantial advances in the development of new interventions for this disorder.

A second topic concerns the study of mechanisms underlying mental retardation in DS (trisomy 21), the most common genetic cause of mental retardation and autosomal aneuplodia compatible with postnatal survival. The study is aimed to clarify the possible causes underlying changes in neurogenesis during critical phases of brain development. Research is carried out in the Ts65dn mouse model of DS and in human fetuses. In an attempt to find effective treatments, possibly useful in humans, we are focusing on therapies that could enhance neuron production.


TECNOLOGIE IN POSSESSO DELL'U. O.

Behavior Analysis

Molecular cloning

Primary and established cell line culture

Histological and immunohistochemistry procedures

Animal treatments

Western blot analysis

Dendritic arbor reconstruction

Radioactive kinase assay

Phosphoproteomic analysis


STRUMENTAZIONE

Denominazione

Struttura ove la strumentazione è allocata

Responsabile della strumentazione

GloMax® Discover System

DIBINEM Piazza di Porta San Donato 2

Elisabetta Ciani

Nikon Eclipse E600 microscope equipped with a Nikon Digital Camera DXM1200 (ATI System) and Working Station

DIBINEM Piazza di Porta San Donato 2

Elisabetta Ciani


PUBBLICAZIONI

Long-term effect of neonatal inhibition of APP gamma-secretase on hippocampal development in the Ts65Dn mouse model of Down syndrome.

Stagni F, Raspanti A, Giacomini A, Guidi S, Emili M, Ciani E, Giuliani A, Bighinati A, Calzà L, Magistretti J, Bartesaghi R.

Neurobiol Dis. 2017 Jul;103:11-23. doi: 10.1016/j.nbd.2017.03.012. Epub 2017 Mar 28.

 

Lithium Restores Age-related Olfactory Impairment in the Ts65Dn Mouse Model of Down Syndrome.

Guidi S, Bianchi P, Stagni F, Giacomini A, Emili M, Trazzi S, Ciani E, Bartesaghi R.

CNS Neurol Disord Drug Targets. 2017;16(7):812-819. doi: 10.2174/1871527315666160801143108.

 

HDAC4: a key factor underlying brain developmental alterations in CDKL5 disorder.

Trazzi S, Fuchs C, Viggiano R, De Franceschi M, Valli E, Jedynak P, Hansen FK, Perini G, Rimondini R, Kurz T, Bartesaghi R, Ciani E.

Hum Mol Genet. 2016 Sep 15;25(18):3887-3907. doi: 10.1093/hmg/ddw231. Epub 2016 Jul 27.

 

Short- and long-term effects of neonatal pharmacotherapy with epigallocatechin-3-gallate on hippocampal development in the Ts65Dn mouse model of Down syndrome.

Stagni F, Giacomini A, Emili M, Trazzi S, Guidi S, Sassi M, Ciani E, Rimondini R, Bartesaghi R.

Neuroscience. 2016 Oct 1;333:277-301. doi: 10.1016/j.neuroscience.2016.07.031. Epub 2016 Jul 25.

 

Inhibition of APP gamma-secretase restores Sonic Hedgehog signaling and neurogenesis in the Ts65Dn mouse model of Down syndrome.

Giacomini A, Stagni F, Trazzi S, Guidi S, Emili M, Brigham E, Ciani E, Bartesaghi R.

Neurobiol Dis. 2015 Oct;82:385-396. doi: 10.1016/j.nbd.2015.08.001. Epub 2015 Aug 5.

 

Inhibition of GSK3β rescues hippocampal development and learning in a mouse model of CDKL5 disorder.

Fuchs C, Rimondini R, Viggiano R, Trazzi S, De Franceschi M, Bartesaghi R, Ciani E.

Neurobiol Dis. 2015 Oct;82:298-310. doi: 10.1016/j.nbd.2015.06.018. Epub 2015 Jul 2.

 

Long-term effects of neonatal treatment with fluoxetine on cognitive performance in Ts65Dn mice.

Stagni F, Giacomini A, Guidi S, Ciani E, Ragazzi E, Filonzi M, De Iasio R, Rimondini R, Bartesaghi R.

Neurobiol Dis. 2015 Feb;74:204-18. doi: 10.1016/j.nbd.2014.12.005. Epub 2014 Dec 10.

 

Loss of CDKL5 impairs survival and dendritic growth of newborn neurons by altering AKT/GSK-3β signaling.

Fuchs C, Trazzi S, Torricella R, Viggiano R, De Franceschi M, Amendola E, Gross C, Calzà L, Bartesaghi R, Ciani E.

Neurobiol Dis. 2014 Oct;70:53-68. doi: 10.1016/j.nbd.2014.06.006. Epub 2014 Jun 18.

 

APP-dependent alteration of GSK3β activity impairs neurogenesis in the Ts65Dn mouse model of Down syndrome.

Trazzi S, Fuchs C, De Franceschi M, Mitrugno VM, Bartesaghi R, Ciani E.

Neurobiol Dis. 2014 Jul;67:24-36. doi: 10.1016/j.nbd.2014.03.003. Epub 2014 Mar 15.

 

Prenatal pharmacotherapy rescues brain development in a Down's syndrome mouse model.

Guidi S, Stagni F, Bianchi P, Ciani E, Giacomini A, De Franceschi M, Moldrich R, Kurniawan N, Mardon K, Giuliani A, Calzà L, Bartesaghi R.

Brain. 2014 Feb;137(Pt 2):380-401. doi: 10.1093/brain/awt340. Epub 2013 Dec 12.

 


DOTTORATI DI RICERCA

Componente U.O.

Dottorato di Ricerca

Coordinatore

Sede

Elisabetta Ciani

Scienze Biomediche

Prof  Lucio Cocco

Università di Bologna


CONGRESSI C.I.B.

Congressi Partecipazione
CNB4
CNB5
CNB6
CNB7
CNB8
CNB9
CNB10