Direzione e uffici C.I.B.

Direzione CIB:
Prof. Claudio Schneider
Email: claudio.schneider@Lncib.it

Segreteria CIB:
Prof. Roberto Gambari
Email: roberto.gambari@unife.it

SEGRETERIA ORGANIZZATIVA:
Elisabetta Lambertini
Tel: 0532/974451
Fax: 0532/974484
E-mail: lmblbt@unife.it

AMMINISTRAZIONE:
Vanessa Florit
Area di Ricerca
Padriciano, 99 - 34012 Trieste
Tel: 040/398979
Fax: 040/398990
E-mail: cib@lncib.it

Posta certificata C.I.B.:
cib@poste-certificate.it

Login



Rusnati Marco Stampa
RESPONSABILE DELLA U. O.
Cognome e Nome Rusnati Marco
Qualifica Full Professor
Dipartimento Molecular and Translational Medicine, University of Brescia
Settore Scientifico Disciplinare MED04 “Patologia Generale”
E-mail Questo indirizzo e-mail è protetto dallo spam bot. Abilita Javascript per vederlo.
Tel +39-030-3717315  cell: +39-366-6692550

PERSONALE STRUTTURATO

Cognome e Nome Urbinati Chiara
Qualifica Technician
Dipartimento Molecular and Translational Medicine
Ente di appartenenza University of Brescia
Cognome e Nome Ravelli Cosetta
Qualifica Technician
Dipartimento Molecular and Translational Medicine
Ente di appartenenza University of Brescia
Cognome e Nome Tobia Chiara
Qualifica Technician
Dipartimento Molecular and Translational Medicine
Ente di appartenenza University of Brescia

PERSONALE NON STRUTTURATO

Cognome e Nome Paiardi Giulia
Qualifica PhD student, technology for health, University of Brescia
Dipartimento Molecular and Translational Medicine
Ente di appartenenza University of Brescia
Cognome e Nome Chiodelli Paola
Qualifica Post-Doc research fellow, University of Brescia
Dipartimento Molecular and Translational Medicine
Ente di appartenenza University of Brescia

LINEE DI RICERCA

1983-1985: Purification and biochemical characterization of D-amino acid oxidase.

1986-1992: Purification and characterization angiogenic factors (FGFs), identification of their functional domains.

1992-present: Interaction of FGFs with their receptors and co-receptors present onto the cell-membrane or in the extracellular matrix of endothelium.

1996-present: Extracellular activity of HIV Tat, gp120 and p17, study of their interaction with soluble, extracellular matrix or cell-associated binders/receptors.

2001-present: Study of molecular interaction by surface plasmon resonance (BIAcore technology).

2006-present: Study of the role of glycosilation of integrins and VEGFR2 in angiogenesis

2008-present: Development of inhibitor of HPV, HSV & RSV infection.

2015-present: Screening of compounds acting as antagonists of the Eph-ephrin system.

2014-present: Screening of compounds acting as cystic fibrosis therapeutics.


TECNOLOGIE IN POSSESSO DELL'U. O.

  • Recombinant proteins
  • Angiogenesis assays
  • Fast liquid protein chromatography
  • Surface plasmon resonance interaction assay
  • Time-lapse microscopy
  • Protein mutagenesis
  • Retro and lentivirus cell transfection

STRUMENTAZIONE

Denominazione Struttura ove la strumentazione è allocata Responsabile della strumentazione
BIACORE X-100 surface plasmon resonance unit for macromolecular interaction assay Section of Experimental Oncology and Immunology Prof. Marco Rusnati

PUBBLICAZIONI

Speeding Up the Identification of Cystic Fibrosis Transmembrane Conductance Regulator-Targeted Drugs: An Approach Based on Bioinformatics Strategies and Surface Plasmon Resonance. Rusnati M, Sala D, Orro A, Bugatti A., Trombetti Cichero E, Urbinati C, Di Somma M, Millo E, Galietta LJV, Milanesi L, Fossa P, D’Ursi P. Molecules. 2018 jan 23(1), 120; doi:10.3390/molecules23010120

Contribution of vascular endothelial growth factor receptor-2 sialylation to the process of angiogenesis. Chiodelli P, Rezzola S, Urbinati C, Federici Signori F, Monti E, Ronca R, Presta M, Rusnati M. Oncogene. 2017 Nov 23;36(47):6531-6541. doi: 10.1038/onc.2017.243. Epub 2017 Aug 7. PMID: 28783175

Syndecan-1 increases B-lymphoid cell extravasation in response to HIV-1 Tat via αvβ3/pp60src/pp125FAK pathway. Urbinati C, Grillo E, Chiodelli P, Tobia C, Caccuri F, Fiorentini S, David G, Rusnati M. Oncogene. 2017 May 4;36(18):2609-2618. doi: 10.1038/onc.2016.420. Epub 2016 Nov 7. PMID: 27819680

Heparin/Heparan sulfate proteoglycans glycomic interactome in angiogenesis: biological implications and therapeutical use. Chiodelli P, Bugatti A, Urbinati C, Rusnati M. Molecules. 2015 Apr 10;20(4):6342-88. doi: 10.3390/molecules20046342. PMID: 25867824

Angiogenic growth factors interactome and drug discovery: The contribution of surface plasmon resonance. Rusnati M, Presta M. Cytokine Growth Factor Rev. 2015 Jun;26(3):293-310. doi: 10.1016/j.cytogfr.2014.11.007. Epub 2014 Nov 20. PMID: 25465594

Bridging the past and the future of virology: surface plasmon resonance as a powerful tool to investigate virus/host interactions. Rusnati M, Chiodelli P, Bugatti A, Urbinati C. Crit Rev Microbiol. 2015 Jun;41(2):238-60. doi: 10.3109/1040841X.2013.826177. Epub 2013 Sep 23. PMID: 24059853

Molecular interaction studies of HIV-1 matrix protein p17 and heparin: identification of the heparin-binding motif of p17 as a target for the development of multitarget antagonists. Bugatti A, Giagulli C, Urbinati C, Caccuri F, Chiodelli P, Oreste P, Fiorentini S, Orro A, Milanesi L, D'Ursi P, Caruso A, Rusnati M. J Biol Chem. 2013 Jan 11;288(2):1150-61. doi: 10.1074/jbc.M112.400077. Epub 2012 Nov 19. PMID: 23166320

Sialic acid associated with αvβ3 integrin mediates HIV-1 Tat protein interaction and endothelial cell proangiogenic activation. Chiodelli P, Urbinati C, Mitola S, Tanghetti E, Rusnati M. J Biol Chem. 2012 Jun 8;287(24):20456-66. doi: 10.1074/jbc.M111.337139. Epub 2012 Apr 23. PMID: 22528484

Substrate-immobilized HIV-1 Tat drives VEGFR2/α(v)β(3)-integrin complex formation and polarization in endothelial cells. Urbinati C, Ravelli C, Tanghetti E, Belleri M, Giacopuzzi E, Monti E, Presta M, Rusnati M. Arterioscler Thromb Vasc Biol. 2012 May;32(5):e25-34. doi: 10.1161/ATVBAHA.111.242396. Epub 2012 Feb 23. PMID: 22362758

Heparan sulfate proteoglycans mediate the angiogenic activity of the vascular endothelial growth factor receptor-2 agonist gremlin. Chiodelli P, Mitola S, Ravelli C, Oreste P, Rusnati M, Presta M. Arterioscler Thromb Vasc Biol. 2011 Dec;31(12):e116-27. doi: 10.1161/ATVBAHA.111.235184. Epub 2011 Sep 15. PMID: 21921258


DOTTORATI DI RICERCA

Componente U.O. Dottorato di Ricerca Coordinatore Sede
Rusnati Marco Technology for Health Prof. Sardini Emilio Brescia

CONGRESSI C.I.B.


Congressi Partecipazione
Congresso di torino Si