Direzione e uffici C.I.B.

Direzione CIB:
Prof. Claudio Schneider
Email: claudio.schneider@Lncib.it

Segreteria CIB:
Prof. Roberto Gambari
Email: roberto.gambari@unife.it

SEGRETERIA ORGANIZZATIVA:
Elisabetta Lambertini
Tel: 0532/974451
Fax: 0532/974484
E-mail: lmblbt@unife.it

AMMINISTRAZIONE:
Vanessa Florit
Area di Ricerca
Padriciano, 99 - 34012 Trieste
Tel: 040/398979
Fax: 040/398990
E-mail: cib@lncib.it

Posta certificata C.I.B.:
cib@poste-certificate.it

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Cenacchi Giovanna Stampa
RESPONSABILE DELLA U. O.

Cognome e Nome Cenacchi Giovanna
Qualifica Associate Professor
Dipartimento DIBINEM
Settore Scientifico Disciplinare MED 08
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PERSONALE STRUTTURATO

Cognome e Nome Foschini Maria Pia
Qualifica Full Professor
Dipartimento Dibinem
Ente di appartenenza Università di Bologna
Cognome e Nome Asioli Sofia
Qualifica Assistant Professor
Dipartimento Dibinem
Ente di appartenenza Università di Bologna
Cognome e Nome Costa Roberta
Qualifica PhD Technician
Dipartimento Dibinem
Ente di appartenenza Università di Bologna
Cognome e Nome Morandi Luca
Qualifica PhD Technician
Dipartimento Dibinem
Ente di appartenenza Università di Bologna

PERSONALE NON STRUTTURATO

Cognome e Nome Papa Valentina
Qualifica Biologist, Technician
Dipartimento Dibinem
Ente di appartenenza Università di Bologna
Cognome e Nome Rodia Maria Teresa
Qualifica Post-Doc
Dipartimento Dibinem
Ente di appartenenza Università di Bologna

LINEE DI RICERCA

The research topics are mainly focused on neoplastic pathology (breast, head-neck, neuro-endocrine system, central nervous system ) and on muscle pathology.

The multicentricity and multifocality of breast ductal carcinoma is investigated through the study of clonality with mitochondrial DNA analysis and through the concept of field cancerization especially  on resection margins.  Moreover,  the diagnostic  and prognostic values of  DNA methylation analyzing several target genes by quantitative bisulfite next-generation sequencing and miRNAs analysis  in oral carcinoma (follow-up of pre-neoplastic lesions using genetic markers on scraping to identify patients to be biopsied) is evaluated. Finally we investigate potential prognostic and predictive value of  morphological / biomolecular markers to predict survival and response to therapy in high grade osteosarcoma  of maxillary bones.

Central Nervous System: one focus of research is on the evaluation of the prognostic impact of Galectin 3 on ACTH pituitary . Another  is   the correlations between morphology of recurrences of glioblastoma multiforme (GBM) and response to radio-chemotherapeutic treatment.

The research in muscle pathology mainly addresses to the study of etio-pathogenetic mechanism in muscle dystrophies with specific interest in muscle dystrophy 1F, a rare disease with  dominant autosomic inheritance by ultrastructural study on patient biopsies and an in vitro study by WB, CRISPR-CAS 9 and immunohistochemistry (IF at confocal microscopy). Mutation on Transportin 3 gene has been recently identified (Transportin 3 protein of the importin/exportin family) . A relationship between nucleus and cytoskeletal system has been established with likely important role in functional alteration allowing to muscle atrophy.  On the same in vitro model in collaboration with prof Angelini’s group (IRCCS S.Camillo, Ve) we are studying the expression of  the muscle-specific miRNA  during myoblast differentiation related to Transportin 3 expression. Transmission electron microscopy is constantly a useful tool in both SNC and muscle pathology studies


TECNOLOGIE IN POSSESSO DELL'U. O.

Mutational Anlysis by Next Generation sequencing (NGS)

CRISPR-Cas9

DNA metylation anlysis by bisulfite NGS

Array Comparative Genomic Hybridization

non coding RNA analysis by NGS

 

Microscopia elettronica

 

Colture cellulari

 


STRUMENTAZIONE

Denominazione

Struttura ove la strumentazione è allocata

Responsabile della strumentazione

Ventana Benchmark Automated slides stainer

Anatomia Patologica Ospedale Bellaria

Prof.  Maria Pia Foschni

Micro array Scanner Agilent

Anatomia Patologica Ospedale Bellaria

Prof.  Maria Pia Foschni


PUBBLICAZIONI

Ghetti M, Topouzi H, Theocharidis G, Papa V, Williams G, Bondioli E, Cenacchi G, Connelly JT, Higgins CA.Sub-Populations of Dermal Skin Fibroblasts Secrete Distinct Extracellular Matrix: Implications for Using Skin Substitutes in the Clinic. Br J Dermatol. 2017 Dec 20. doi: 10.1111/bjd.16255. [Epub ahead of print]

 

Iannello G, Graziano C, Cenacchi G, Cordelli DM, Zuntini R, Papa V, Magistà AM, Gagliardi M, Procopio R, Quattrone A, Annesi G.J A new PLA2G6 mutation in a family with infantile neuroaxonal dystrophy. Neurol Sci. 2017 Oct 15;381:209-212. doi: 10.1016/j.jns.2017.08.3260. Epub 2017 Sep 1. Erratum in: J Neurol Sci. 2017 Dec 15;:.

 

Morelli FF, Verbeek DS, Bertacchini J, Vinet J, Mediani L, Marmiroli S, Cenacchi G, Nasi M, De Biasi S, Brunsting JF, Lammerding J, Pegoraro E, Angelini C, Tupler R, Alberti S, Carra S.Aberrant Compartment Formation by HSPB2 Mislocalizes Lamin A and Compromises Nuclear Integrity and Function. Cell Rep. 2017 Aug 29;20(9):2100-2115. doi: 10.1016/j.celrep.2017.08.018

 

Mignani R, Moschella M, Cenacchi G, Donati I, Flachi M, Grimaldi D, Cerretani D, Giovanni P, Montevecchi M, Rigotti A, Ravasio A.Different renal phenotypes in related adult males with Fabry disease with the same classic genotype. Mol Genet Genomic Med. 2017 May 8;5(4):438-442. doi: 10.1002/mgg3.292. eCollection 2017 Jul

 

Papa V, Romanin B, Bergamaschi R, Cordelli DM, Costa R, De Giorgi LB, Cenacchi G.Juvenile dermatomyositis: A report of three cases. Ultrastruct Pathol. 2016;40(2):83-5. doi: 10.3109/01913123.2016.1141823. Epub 2016 Feb 17.

 

Turri-Zanoni M, Maragliano R, Battaglia P, Giovannardi M, Antognoni P,Lombardi D, Morassi ML, Pasquini E, Tarchini P, Asioli S, Foschini MP, Sessa F,Nicolai P, Castelnuovo P, La Rosa S. The clinicopathological spectrum ofolfactory neuroblastoma and sinonasal neuroendocrine neoplasms: Refinements indiagnostic criteria and impact of multimodal treatments on survival. Oral Oncol. 2017 Nov;74:21-29. doi: 10.1016/j.oraloncology.2017.09.010. PubMed PMID:

 

Ambrosi F, Righi A, Ricci C, Erickson LA, Lloyd RV, Asioli S. Hobnail Variant of Papillary Thyroid Carcinoma: a Literature Review. Endocr Pathol. 2017Dec;28(4):293-301. doi: 10.1007/s12022-017-9502-7. Review. PubMed PMID: 29019044.

 

Palladini A, Nicoletti G, Lamolinara A, Dall'Ora M, Balboni T, Ianzano ML,Laranga R, Landuzzi L, Giusti V, Ceccarelli C, Santini D, Taffurelli M, Di Oto E,Asioli S, Amici A, Pupa SM, De Giovanni C, Tagliabue E, Iezzi M, Nanni P, LolliniPL. HER2 isoforms co-expression differently tunes mammary tumor phenotypesaffecting onset, vasculature and therapeutic response. Oncotarget. 2017 Apr13;8(33):54444-54458. doi: 10.18632/oncotarget.17088. eCollection 2017 Aug 15.PubMed PMID: 28903354; PubMed Central PMCID: PMC5589593.

 

Morandi L, Gissi D, Tarsitano A, Asioli S, Gabusi A, Marchetti C, MontebugnoliL, Foschini MP. CpG location and methylation level are crucial factors for theearly detection of oral squamous cell carcinoma in brushing samples usingbisulfite sequencing of a 13-gene panel. Clin Epigenetics. 2017 Aug 15;9:85. doi:10.1186/s13148-017-0386-7. eCollection 2017. PubMed PMID: 28814981; PubMedCentral PMCID: PMC5558660.

 

Asioli S, Righi A, Rucci P, Tarsitano A, Marchetti C, Bacchini P, Balbi T,Bertoni F, Foschini MP. p16 protein expression and correlation with clinical and pathological features in osteosarcoma of the jaws: Experience of 37 cases. HeadNeck. 2017 Sep;39(9):1825-1831. doi: 10.1002/hed.24835. Epub 2017 May 31. PubMed PMID: 28560748.

 


DOTTORATI DI RICERCA

Componente U.O.

Dottorato di Ricerca

Coordinatore

Sede

Foschini Maria Pia

Dottorato in oncologia, ematologia e patologia

Prof. Pier Luigi Lollini

Università di Bologna

Asioli Sofia

Dottorato di ricerca in Scienze Biomediche

Prof  Lucio Cocco

Università di Bologna

 

 

 

 


CONGRESSI C.I.B.

Congressi Partecipazione
CNB4
CNB5
CNB6
CNB7
CNB8
CNB9
CNB10