Direzione e uffici C.I.B.

Direzione CIB:
Prof. Claudio Schneider
Email: claudio.schneider@Lncib.it

Segreteria CIB:
Prof. Roberto Gambari
Email: roberto.gambari@unife.it

SEGRETERIA ORGANIZZATIVA:
Elisabetta Lambertini
Tel: 0532/974451
Fax: 0532/974484
E-mail: lmblbt@unife.it

AMMINISTRAZIONE:
Vanessa Florit
Area di Ricerca
Padriciano, 99 - 34012 Trieste
Tel: 040/398979
Fax: 040/398990
E-mail: cib@lncib.it

Posta certificata C.I.B.:
cib@poste-certificate.it

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Calonghi Natalia Stampa
RESPONSABILE DELLA U. O.

Cognome e Nome Calonghi Natalia
Qualifica PA
Facoltà
Dipartimento Pharmacy and Biotechnology
Settore Scientifico Disciplinare BIO/10
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PERSONALE STRUTTURATO

Cognome e Nome Sartor Giorgio
Qualifica PA
Dipartimento Pharmacy and Biotechnology
Ente di appartenenza Alma Mater Studiorum – Università di Bologna
Cognome e Nome Fato Romana
Qualifica PA
Dipartimento Pharmacy and Biotechnology
Ente di appartenenza Alma Mater Studiorum – Università di Bologna
Cognome e Nome Boga Carla
Qualifica Researcher
Dipartimento Science and Technology of Industrial Chemistry
Ente di appartenenza Alma Mater Studiorum – Università di Bologna
Cognome e Nome Passerini Nadia
Qualifica PA
Dipartimento Pharmacy and Biotechnology
Ente di appartenenza Alma Mater Studiorum – Università di Bologna
Cognome e Nome Albertini Beatrice
Qualifica PA
Dipartimento Pharmacy and Biotechnology
Ente di appartenenza Alma Mater Studiorum – Università di Bologna
Cognome e Nome Luppi Barbara
Qualifica PA
Dipartimento Pharmacy and Biotechnology
Ente di appartenenza Alma Mater Studiorum – Università di Bologna
Cognome e Nome Bergamini Christian
Qualifica RTB
Dipartimento Pharmacy and Biotechnology
Ente di appartenenza Alma Mater Studiorum – Università di Bologna

PERSONALE NON STRUTTURATO

Cognome e Nome Parolin Carola
Qualifica Research Fellow
Dipartimento Pharmacy and Biotechnology
Ente di appartenenza Alma Mater Studiorum – Università di Bologna
Cognome e Nome Abruzzo Angela
Qualifica Research Fellow
Dipartimento Pharmacy and Biotechnology
Ente di appartenenza Alma Mater Studiorum – Università di Bologna
Cognome e Nome Wenping Wang
Qualifica PhD student
Dipartimento Pharmacy and Biotechnology
Ente di appartenenza Alma Mater Studiorum – Università di Bologna
Cognome e Nome Bertoni Serena
Qualifica PhD student
Dipartimento Pharmacy and Biotechnology
Ente di appartenenza Alma Mater Studiorum – Università di Bologna

LINEE DI RICERCA

Role of HDAC1 dependent co-regulating complexes in carcinogenesis

Study of calcification mechanism in marine organisms

Structure and function of mitochondrial Complex I

Complex I production of Reactive Oxygen Specie

Study on the effect of toxicants on the functionality of mitochondrial respiratory chain

Development and characterization of innovative systems (micro- and nano- particles, liposomes) for the delivery of Active Pharmaceutical Ingredients: drugs, peptides, proteins, nucleic acids and cells (i.e. probiotic bacteria)

Synthesis of long- and short-chain lipid peroxidation products such as 4-hydroxy-trans-2-nonenal and hydroxystearic acids and their derivatives. Synthesis and reactivity of organic compounds containing the aza group. Identification and characterization of products and of labile intermediates of organic reactions  through NMR spectroscopy studies (1H, 13C, 31P).

TECNOLOGIE IN POSSESSO DELL'U. O.

Confocal Microscopy

HPLC

Production and characterization of liposomes, nano- and micro- particles.

Synthesis, characterization of intermediates and organic compounds using advanced NMR spectroscopy techniques

Western Blot, RT-PCR, Real time PCR, ChIP,

Cell transfection

Flow cytometry

Drug permeation and drug release

Gene silencing

Spectrophotometry and Spectrofluorometry


STRUMENTAZIONE

Denominazione

Struttura ove la strumentazione è allocata

Responsabile della strumentazione

Nikon C1s confocal laser-scanning microscope

Centro Interdipartimentale Ricerche Biotecnologiche (CIRB)

Calonghi

 

Bio-Rad MRC1024 confocal laser microscope

CIRB

Calonghi

 

Fluorimenter Photon Technology International

CIRB

Sartor

Beckman Coulter Epics XL-MCL flow cytometer

CIRB

Faruggia

 

HPLC

CIRB

Sartor

 

Aktapurifier GE Healthcare

CIRB

Sartor

 

RT-PCR

CIRB

Capranico

 

High Field NMR Spectrometers (400 e 600 MHz)

Faculty of Industrial Chemistry

Mazzanti

Gas. Chromatograph Mass Spectrometer Agilent 5973N

Science and Technology of Industrial Chemistry

Boga

Spray-dryer, Spray-congealer, Freeze-dryer, Fluid bed coater

Dept. of Pharmacy and Biotechnology

Passerini/Luppi

HPLC with autosampler

Dept. of Pharmacy and Biotechnology

Passerini/Luppi

Dynamic Light Scattering

Dept. of Pharmacy and Biotechnology

Passerini/Luppi

Differential Scanning Calorimetry (DSC)

Dept. of Pharmacy and Biotechnology

Passerini/Luppi


PUBBLICAZIONI

1. Parolin C, Marangoni A, Laghi L, Foschi C, Ñahui Palomino RA, Calonghi N, Cevenini R, Vitali B. PLoS One. 2015 Jun 22;10(6):e01312201. Isolation of Vaginal Lactobacilli and Characterization of Anti-Candida Activity.

2. Anal Bioanal Chem. 2013 Jan;405(2-3):795-804Bartolini M, Naldi M, Nicolau DV, van Delft FC, van Zijl J, Snijder J, van den Heuvel EF, Naburgh EP, Calonghi N, Andrisano V.2. Fluorescence biosensing micropatterned surfaces based on immobilized human acetylcholinesterase.

3.Biochim Biophys Acta. 2012 Oct;1821(10):1334-40.Parolin C, Calonghi N, Presta E, Boga C, Caruana P, Naldi M, Andrisano V, Masotti L, Sartor G.in colon cancer.3. Mechanism and stereoselectivity of HDAC I inhibition by (R)-9-hydroxystearic acid

4. Int J Pharm. 2013 Jan 20;440(2):238-49Albertini B, Di Sabatino M, Calonghi N, Rodriguez L, Passerini N.4. Novel multifunctional platforms for potential treatment of cutaneous wounds: development and in vitro characterization.

5. Int J Pharm. 2014 Jul 20;469(1):67-79Albertini B, Di Sabatino M, Melegari C, Passerini N.5. Formulating SLMs as oral pulsatile system for potential delivery of melatonin to pediatric population.

6. Eur J Pharm Sci. 2012 Aug 15;46(5):346-56Di Sabatino M, Albertini B, Kett VL, Passerini N.Spray congealed lipid microparticles with high protein loading: preparation and solid state characterisation.

7. PLoS One. 2012;7(3):e33712Bergamini C, Moruzzi N, Sblendido A, Lenaz G, Fato R.A water soluble CoQ10 formulation improves intracellular distribution and promotes mitochondrial respiration in cultured cells.

8. PLoS One. 2014 Sep 30;9(9):e108112Aldini R, Micucci M, Cevenini M, Fato R, Bergamini C, Nanni C, Cont M, Camborata C, Spinozzi S, Montagnani M, Roda G, D'Errico-Grigioni A, Rosini F, Roda A, Mazzella G, Chiarini A, Budriesi R.8. Antiinflammatory effect of phytosterols in experimental murine colitis model: prevention, induction, remission study.

9. J Med Chem. 2014 Oct 23;57(20):8576-89Nepovimova E, Uliassi E, Korabecny J, Peña-Altamira LE, Samez S, Pesaresi A, Garcia GE, Bartolini M, Andrisano V, Bergamini C, Fato R, Lamba D, Roberti M, Kuca K, Monti B, Bolognesi ML.9. Multitarget drug design strategy: quinone-tacrine hybrids designed to block amyloid-β aggregation and to exert anticholinesterase and antioxidant effects.

10. J Med Chem. 2015 Aug 27;58(16):6422-34Prati F, Bergamini C, Molina MT, Falchi F, Cavalli A, Kaiser M, Brun R, Fato R, Bolognesi ML.10. 2-Phenoxy-1,4-naphthoquinones: From a Multitarget Antitrypanosomal to a Potential Antitumor Profile.


DOTTORATI DI RICERCA

Componente U.O.

Dottorato di Ricerca

Coordinatore

Sede

Calonghi Natalia

Biotechnological and Pharmaceutical Sciencess

Prof. Santi Mario Spampinato

Department of Pharmacy and Biotechnology (FaBiT)

Luppi Barbara

Biotechnological and Pharmaceutical Sciences

Prof. Santi Mario Spampinato

Department of Pharmacy and Biotechnology (FaBiT)

Fato Romana Biotechnological and Pharmaceutical Sciences Prof. Santi Mario Spampinato Department of Pharmacy and Biotechnology (FaBiT)

CONGRESSI C.I.B.

Congressi Partecipazione
CNB4

CNB5

CNB6

CNB7
si
CNB8
si
CNB9
CNB10