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RESPONSABILE DELLA U. O. |
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Cognome e Nome |
Nastruzzi Claudio |
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Qualifica |
Professore Associato |
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Facoltà |
Farmacia |
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Dipartimento |
Scienze Farmaceutiche |
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Settore Scientifico Disciplinare |
Chim 09 |
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E-mail |
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PERSONALE STRUTTURATO |
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Cognome e Nome |
Menegatti Enea |
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Qualifica |
PO |
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Dipartimento |
Scienze Farmaceutiche |
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Ente di appartenenza |
Università di Ferrara |
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Cognome e Nome |
Cortesi Rita |
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Qualifica |
PA |
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Dipartimento |
Scienze Farmaceutiche |
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Ente di appartenenza |
Università di Ferrara |
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Cognome e Nome |
Bortolotti Fabrizio |
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Qualifica |
Dirigente Tecnico |
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Dipartimento |
Scienze Farmaceutiche |
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Ente di appartenenza |
Università di Ferrara |
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PERSONALE NON STRUTTURATO |
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Cognome e Nome |
Esposito Elisabetta |
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Qualifica |
Assegnista |
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Dipartimento |
Scienze Farmaceutiche |
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Ente di appartenenza |
Università di Ferrara |
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Cognome e Nome |
Tosi Azzurra |
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Qualifica |
Assegnista |
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Dipartimento |
Scienze Farmaceutiche |
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Ente di appartenenza |
Università di Ferrara |
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Cognome e Nome |
Mazzitelli Stefania |
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Qualifica |
Dottorato Ricerca |
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Dipartimento |
Biochimica e Biologia Molecolare |
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Ente di appartenenza |
Università di Ferrara |
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Cognome e Nome |
Focaroli Stefano |
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Qualifica |
Stagista Alta Formazione |
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Dipartimento |
Scienze Farmaceutiche |
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Ente di appartenenza |
Università di Ferrara |
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Cognome e Nome |
Capretto Lorenzo |
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Qualifica |
Dottorato Ricertca |
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Dipartimento |
Chemical Engineering |
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Ente di appartenenza |
Universy of Southampton |
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LINEE DI RICERCA |
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Nano- and Micro-systems for drug delivery
Controlled release of biological response modifiers. Production and characterization of particulate delivery systems: liposomes, microspheres for gene therapy.
Conduits for nerve repair
Development and optimization of different bioencapsulation methods for the production of conduits for nerve repair. Study of new materials for cell encapsulation and identification of new processes allowing the use of these materials under mild and biocompatible conditions.
Lab-on-a-chip
Prodution and characterization of nano- and microparticellar system for biopharmaceutical applications on a Lab-on-a-chip based microelectronic technology".
Phytonutrients
Design, production and characterization of microparticles made of enteric resistant polymers to prevent phytonutrients release to the stomach and to the upper small intestine.
Lipospheres
Lipidic microspheres, lipospheres (LS) as new type of fat-based encapsulation system developed for drug delivery of bioactive compounds (especially lipophilic compounds). LS combine the advantages of polymeric nanoparticles, fat emulsions and liposomes avoiding some of their disadvantages, such as cytotoxic effects after phagocytosis, toxic effects of organic residues after the production of polymers, lack of large industrial scale production
Multifunctional microcapsules for islets entrapment
We introduced a new approach for the integrated immunoprotection of transplanted islets, irrespective of the islet origin and maturation level. In this approach, the ‘‘islet compartment’’ benefit from a ‘‘chemical/pharmacologic agent compartment’’ constituted of a sustained release formulation able to deliver the included biological response modifiers for long periods of time.
Liposomes, micelles and microemulsions as delivery systems for biological response modifiers
Design and performance of specialized delivery systems (SDSs), such as liposomes, micellar solutions and microemulsions.
Prototyping
Rapid prototyping technology for the very quick production of three-dimensional objects, without expensive tooling techniques during the product development stage. |
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TECNOLOGIE IN POSSESSO DELL'U. O. |
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- Nano- and Micro-systems for drug delivery
- Liposomes, micelles and microemulsions as delivery systems
- Conduits for nerve repair
- Multifunctional microcapsules for islets entrapment
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STRUMENTAZIONE |
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Denominazione
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Struttura ove la strumentazione è allocata
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Responsabile della strumentazione
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HPLC
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Dip. Chimica e Tecnol. Farmaco
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Claudio Nastruzzi
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Spray Drier
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Dip. Chimica e Tecnol. Farmaco
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Claudio Nastruzzi
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Vibrating encapsulator
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Dip. Chimica e Tecnol. Farmaco
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Claudio Nastruzzi
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DSC
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Dip. Chimica e Tecnol. Farmaco
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Claudio Nastruzzi
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Laser granulometer
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Dip. Chimica e Tecnol. Farmaco
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Claudio Nastruzzi
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Photon correlation spectrophotometer
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Dip. Chimica e Tecnol. Farmaco
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Claudio Nastruzzi
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Rheometer
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Dip. Chimica e Tecnol. Farmaco
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Claudio Nastruzzi
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Lab cell colture cell
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Dip. Medicina Interna
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Claudio Nastruzzi
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PUBBLICAZIONI |
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1: Fallarino F, Luca G, Calvitti M, Mancuso F, Nastruzzi C, Fioretti MC, Grohmann, U, Becchetti E, Burgevin A, Kratzer R, van Endert P, Boon L, Puccetti P, Calafiore R. Therapy of experimental type 1 diabetes by isolated Sertoli cell xenografts alone. J Exp Med. 2009 Oct 26;206(11):2511-26.
2: Penolazzi L, Tavanti E, Vecchiatini R, Lambertini E, Vesce F, Gambari R, Mazzitelli S, Mancuso F, Luca G, Nastruzzi C, Piva R. Encapsulation of Mesenchymal Stem Cells from Warthon's Jelly in Alginate Microbeads. Tissue Eng Part C Methods. 2009 Apr 29.
3: Mazzitelli S, Tosi A, Balestra C, Nastruzzi C, Luca G, Mancuso F, Calafiore R, Calvitti M. Production and characterization of alginate microcapsules produced by a vibrational encapsulation device. J Biomater Appl. 2008 Sep;23(2):123-45.
4: Perioli L, Pagano C, Mazzitelli S, Rossi C, Nastruzzi C. Rheological and functional characterization of new antiinflammatory delivery systems designed for buccal administration. Int J Pharm. 2008 May 22;356(1-2):19-28.
5: Capretto L, Mazzitelli S, Balestra C, Tosi A, Nastruzzi C. Effect of the gelation process on the production of alginate microbeads by microfluidic chip technology. Lab Chip. 2008 Apr;8(4):617-21. Epub 2008 Feb 25.
6: Cortesi R, Marastoni M, Tomatis R, Menegatti E, Esposito E, Nastruzzi C. Peptide-based cationic molecules for the production of positive charged liposomes and micelles. J Microencapsul. 2008 Mar;25(2):71-81.
7: Luca G, Calvitti M, Nastruzzi C, Bilancetti L, Becchetti E, Angeletti G, Mancuso F, Calafiore R. Encapsulation, in vitro characterization, and in vivo biocompatibility of Sertoli cells in alginate-based microcapsules. Tissue Eng. 2007 Mar;13(3):641-8.
8: Cortesi R, Esposito E, Cuccu I, Romagnoli R, Menegatti E, Zaid AN, Nastruzzi C. Liposomes and micellar dispersions for delivery of benzoheterocyclic derivatives of distamycin A. Drug Deliv. 2007 Jan;14(1):1-8.
9: Tosi A, Mazzitelli S, Bozzuto N, Bertini B, Luca G, Nastruzzi C. Tripalmitin-based cationic lipospheres: preparation, characterization and in Lab-on-a-chip applications. J Control Release. 2006 Nov 28;116(2):e58-60.
10: Luca G, Calvitti M, Nastruzzi C, Macchiarulo G, Becchetti E, Neri LM, Capitani S, Basta G, Brunetti P, Calafiore R, Cameron DF. Effects of simulated microgravity on the morphology and function of neonatal porcine cell clusters cultured with and without Sertoli cells. Cell Transplant. 2006;15(1):55-65
11: Borgatti M, Altomare L, Abonnec M, Fabbri E, Manaresi N, Medoro G, Romani A, Tartagni M, Nastruzzi C, Di Croce S, Tosi A, Mancini I, Guerrieri R, Gambari R. Dielectrophoresis-based 'Lab-on-a-chip' devices for programmable binding of microspheres to target cells. Int J Oncol. 2005 Dec;27(6):1559-66.
12: Puglia C, Esposito E, Menegatti E, Nastruzzi C, Rizza L, Cortesi R, Bonina F. Effect of charge and lipid concentration on in-vivo percutaneous absorption of methyl nicotinate from liposomal vesicles. J Pharm Pharmacol. 2005 Sep;57(9):1169-76.
13: Fundueanu G, Constantin M, Esposito E, Cortesi R, Nastruzzi C, Menegatti E. Cellulose acetate butyrate microcapsules containing dextran ion-exchange resins as self-propelled drug release system. Biomaterials. 2005 Jul;26(20):4337-47.
14: Luca G, Nastruzzi C, Calvitti M, Becchetti E, Baroni T, Neri LM, Capitani S, Basta G, Brunetti P, Calafiore R. Accelerated functional maturation of isolated neonatal porcine cell clusters: in vitro and in vivo results in NOD mice. Cell Transplant. 2005;14(5):249-61.
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DOTTORATI DI RICERCA |
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Componente U.O.
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Dottorato di Ricerca
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Coordinatore
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Sede
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Nastruzzi Claudio
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Dottorato di Ricerca in Bioscienze, Biotecnologie e Biomateriali nelle Malattie Vascolari e Endocrino-Metaboliche
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Paolo Gresele
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Perugia
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CONGRESSI C.I.B. |
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Partecipazione |
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CNB4
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CNB5
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CNB6
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CNB7
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CNB8
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Consorzio (sedi e unità operative) 