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RESPONSABILE DELLA U. O. |
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Cognome e Nome |
Nastruzzi Claudio |
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Qualifica |
Professore Associato |
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Dipartimento |
Scienze Chimiche e Farmaceutiche |
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Settore Scientifico Disciplinare |
Chim 09 |
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E-mail |
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PERSONALE STRUTTURATO |
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Cognome e Nome |
Cortesi Rita |
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Qualifica |
PA |
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Dipartimento |
Scienze Chimiche e Farmaceutiche |
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Ente di appartenenza |
Università di Ferrara |
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E- mail: |
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Cognome e Nome |
Esposito Elisabetta |
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Qualifica |
RTD-B |
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Dipartimento |
Scienze Chimiche e Farmaceutiche |
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Ente di appartenenza |
Università di Ferrara |
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E- mail: |
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PERSONALE NON STRUTTURATO |
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Cognome e Nome |
Sguizzato Maddalena |
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Qualifica |
Assegnista di Ricerca |
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Dipartimento |
Scienze Chimiche e Farmaceutiche |
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Ente di appartenenza |
Università di Ferrara |
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Cognome e Nome |
HALLAN Singh Supandeep |
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Qualifica |
Dottorando |
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Dipartimento |
Scienze Chimiche e Farmaceutiche |
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Ente di appartenenza |
Università di Ferrara |
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LINEE DI RICERCA |
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Nano- and Micro-systems for drug delivery
Controlled release of biological response modifiers. Production and characterization of particulate delivery systems: liposomes, cubosomes, microspheres for gene therapy
Conduits for nerve repair
Development and optimization of different bioencapsulation methods for the production of conduits for nerve repair. Study of new materials for cell encapsulation and identification of new processes allowing the use of these materials under mild and biocompatible conditions
Lab-on-a-chip
Prodution and characterization of nano- and microparticellar system for biopharmaceutical applications on a Lab-on-a-chip based microelectronic technology"
Phytonutrients
Design, production and characterization of microparticles made of enteric resistant polymers to prevent phytonutrients release to the stomach and to the upper small intestine
Lipospheres
Lipidic microspheres, lipospheres (LS) as new type of fat-based encapsulation system developed for drug delivery of bioactive compounds (especially lipophilic compounds). LS combine the advantages of polymeric nanoparticles, fat emulsions and liposomes avoiding some of their disadvantages, such as cytotoxic effects after phagocytosis, toxic effects of organic residues after the production of polymers, lack of large industrial scale production
Multifunctional microcapsules for islets entrapment
We introduced a new approach for the integrated immunoprotection of transplanted islets, irrespective of the islet origin and maturation level. In this approach, the ‘‘islet compartment’’ benefit from a ‘‘chemical/pharmacologic agent compartment’’ constituted of a sustained release formulation able to deliver the included biological response modifiers for long periods of time
Liposomes, micelles and microemulsions as delivery systems for biological response modifiers
Design and performance of specialized delivery systems (SDSs) such as liposomes, micellar solutions and microemulsions
Prototyping
Rapid prototyping technology for the quick production of three-dimensional objects without expensive tooling techniques during the product development stage
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TECNOLOGIE IN POSSESSO DELL'U. O. |
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- Nano- and Micro-systems for drug delivery
- Liposomes, micelles and microemulsions as delivery systems
- Conduits for nerve repair
- Multifunctional microcapsules for islets entrapment
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STRUMENTAZIONE |
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Denominazione
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Struttura ove la strumentazione è allocata
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Responsabile della strumentazione
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HPLC
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Dip. Scienze Chimiche e Farmaceutiche
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Claudio Nastruzzi, Rita Cortesi
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Spray Drier
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Dip. Scienze Chimiche e Farmaceutiche
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Claudio Nastruzzi, Rita Cortesi |
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Vibrating encapsulator
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Dip. Scienze Chimiche e Farmaceutiche
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Claudio Nastruzzi
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DSC
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Dip. CScienze Chimiche e Farmaceuticheo
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Claudio Nastruzzi
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Laser granulometer
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Dip. Scienze Chimiche e Farmaceutiche
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Claudio Nastruzzi
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Zetasizer Nano 90S
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Dip. Scienze Chimiche e Farmaceutiche
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Rita Cortesi
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Rheometer
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Dip. Scienze Chimiche e Farmaceutiche
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Claudio Nastruzzi |
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PUBBLICAZIONI |
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1. Esposito E, Nastruzzi C, Sguizzato M, Cortesi R. Nanomedicines to Treat Skin Pathologies with Natural Molecules. Curr Pharm Des. 2019;25(21):2323-2337. doi: 10.2174/1381612825666190709210703.
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2. Esposito E, Sguizzato M, Drechsler M, Mariani P, Carducci F, Nastruzzi C, Valacchi G, Cortesi R. Lipid nanostructures for antioxidant delivery: a comparative preformulation study. Beilstein J Nanotechnol. 2019 Aug 29;10:1789-1801. doi: 10.3762/bjnano.10.174. eCollection 2019.
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3. Pitingolo G, Taly V, Nastruzzi C. Coins in microfluidics: From mere scale objects to font of inspiration for microchannel circuits. Biomicrofluidics. 2019 Apr 9;13(2):024106. doi: 10.1063/1.5086535. eCollection 2019 Mar.
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4. Pitingolo G, Riaud A, Nastruzzi C, Taly V. Gelatin-Coated Microfluidic Channels for 3D Microtissue Formation: On-Chip Production and Characterization. Micromachines (Basel). 2019 Apr 19;10(4). pii: E265. doi: 10.3390/mi10040265.
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5. Esposito E, Pecorelli A, Sguizzato M, Drechsler M, Mariani P, Carducci F, Cervellati F, Nastruzzi C, Cortesi R, Valacchi G. Production and Characterization of Nanoparticle Based Hyaluronate Gel Containing Retinyl Palmitate for Wound Healing. Curr Drug Deliv. 2018;15(8):1172-1182. doi: 10.2174/1567201815666180518123926.
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6. Mancuso F, Calvitti M, Milardi D, Grande G, Falabella G, Arato I, Giovagnoli S, Vincenzoni F, Mancini F, Nastruzzi C, Bodo M, Baroni T, Castagnola M, Marana R, Pontecorvi A, Calafiore R, Luca G. Testosterone and FSH modulate Sertoli cell extracellular secretion: Proteomic analysis. Mol Cell Endocrinol. 2018 Nov 15;476:1-7. doi: 10.1016/j.mce.2018.04.001. Epub 2018 Apr 25.
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7. Esposito E, Sguizzato M, Bories C, Nastruzzi C, Cortesi R. Production and Characterization of a Clotrimazole Liposphere Gel for Candidiasis Treatment. Polymers (Basel). 2018 Feb 8;10(2). pii: E160. doi: 10.3390/polym10020160.
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8. Mancuso F, Arato I, Lilli C, Bellucci C, Bodo M, Calvitti M, Aglietti MC, dell'Omo M, Nastruzzi C, Calafiore R, Luca G, Marinucci L. Acute effects of lead on porcine neonatal Sertoli cells in vitro. Toxicol In Vitro. 2018 Apr;48:45-52. doi: 10.1016/j.tiv.2017.12.013. Epub 2017 Dec 19.
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9. Esposito E, Sguizzato M, Drechsler M, Mariani P, Carducci F, Nastruzzi C, Cortesi R. Progesterone lipid nanoparticles: Scaling up and in vivo human study. Eur J Pharm Biopharm. 2017 Oct;119:437-446. doi: 10.1016/j.ejpb.2017.07.015. Epub 2017 Jul 29.
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10. Angelozzi M, Penolazzi L, Mazzitelli S, Lambertini E, Lolli A, Piva R, Nastruzzi C. Dedifferentiated Chondrocytes in Composite Microfibers As Tool for Cartilage Repair. Front Bioeng Biotechnol. 2017 Jun 13;5:35. doi: 10.3389/fbioe.2017.00035. eCollection 2017.
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DOTTORATI DI RICERCA |
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Componente U.O.
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Dottorato di Ricerca
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Coordinatore
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Sede
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Nastruzzi Claudio
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Scienze Chimiche
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Alberto Cavazzini
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Ferrara |
| Rita Cortesi |
Scienze Chimiche |
Alberto Cavazzini |
Ferrara |
| Elisabetta Esposito |
Scienze Chimiche |
Alberto Cavazzini |
Ferrara |
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CONGRESSI C.I.B. |
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| Congressi |
Partecipazione |
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CNB4
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CNB5
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CNB6
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