Direzione e uffici C.I.B.

Direzione CIB:
Prof. Claudio Schneider
Email: claudio.schneider@Lncib.it

Segreteria CIB:
Prof. Roberto Gambari
Email: roberto.gambari@unife.it

SEGRETERIA ORGANIZZATIVA:
Elisabetta Lambertini
Tel: 0532/974451
Fax: 0532/974484
E-mail: lmblbt@unife.it

AMMINISTRAZIONE:
Vanessa Florit
Area di Ricerca
Padriciano, 99 - 34012 Trieste
Tel: 040/398979
Fax: 040/398990
E-mail: cib@lncib.it

Posta certificata C.I.B.:
cib@poste-certificate.it

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Mecucci Cristina Stampa
       
  RESPONSABILE DELLA U. O.  
 
   
  Cognome e Nome Mecucci Cristina  
  Qualifica
Full Professor in Hematology
 
  Facoltà
Medicine
 
  Dipartimento
Clinical and Experimental Medicine
 
  Settore Scientifico Disciplinare
MED15
 
  E-mail Questo indirizzo e-mail è protetto dallo spam bot. Abilita Javascript per vederlo.  
 
 
  PERSONALE STRUTTURATO    
 
   
  Cognome e Nome Velardi Andrea  
  Qualifica
PO
 
  Dipartimento
Clinical and Experimental Medicine
 
  Ente di appartenenza
University of Perugia
 
     
  Cognome e Nome
Mecucci Cristina
 
  Qualifica
PO
 
  Dipartimento
Clinical and Experimental Medicine
 
  Ente di appartenenza
University of Perugia
 
     
  Cognome e Nome La Starza Roberta  
  Qualifica
RC
 
  Dipartimento
Clinical and Experimental Medicine
 
  Ente di appartenenza
University of Perugia
 
     
  Cognome e Nome Romoli Silvia  
  Qualifica Technician  
  Dipartimento Hematology,Oncology and Radiotherapy  
  Ente di appartenenza Azienda Ospedaliera Perugia  
     
  Cognome e Nome Beacci Donatella  
  Qualifica Technician  
  Dipartimento Hematology, Oncology and Radiotherapy  
  Ente di appartenenza Azienda Ospedaliera Perugia  
     
  Cognome e Nome Crescenzi Barbara  
  Qualifica Biologist  
  Dipartimento Hematology,Oncology and Radiotherapy  
  Ente di appartenenza Azienda Ospedaliera Perugia  
       
  Cognome e Nome Matteucci Caterina  
  Qualifica Biologist  
  Dipartimento Clinical and Experimental Medicine  
  Ente di appartenenza University of Perugia  
 
 
  PERSONALE NON STRUTTURATO  
 
   
  Cognome e Nome Valentina Pierini  
  Qualifica Technician  
  Dipartimento Clinical and Experimental Medicine  
  Ente di appartenenza University of Perugia  
     
  Cognome e Nome
Gianluca Barba
 
  Qualifica Post-doc  
  Dipartimento
Clinical and Experimental Medicine
 
  Ente di appartenenza
University of Perugia
 
     
  Cognome e Nome Paolo Gorello  
  Qualifica Post-doc  
  Dipartimento Clinical and Experimental Medicine  
  Ente di appartenenza University of Perugia  
     
  Cognome e Nome
Lucia Brandimarte
 
  Qualifica
Post-doc
 
  Dipartimento
Clinical and Experimental Medicine
 
  Ente di appartenenza
University of Perugia
 
     
  Cognome e Nome Valeria Nofrini  
  Qualifica
PhD Student
 
  Dipartimento
Clinical and Experimental Medicine
 
  Ente di appartenenza
University of Perugia
 
     
  Cognome e Nome Danika Di Giacomo  
  Qualifica PhD Student  
  Dipartimento Clinical and Experimental Medicine  
  Ente di appartenenza University of Perugia  
     
 
 
  LINEE DI RICERCA    
 
   
  Our Unit is specialized in the genomic analysis of malignant cells using molecular cytogenetics and other advanced genome technologies (CGH, microarrays, sequencing) to integrate conventional cytogenetics.  Our aim is to search for new molecular events related to distinct clinical and/or pathological findings. Moreover we apply large molecular screenings by RT-PCR for emerging fusion genes, in order to be able to establish the incidence of a given rearrangement. All cases are carefully investigated at clinical, haematological and immunological level, according to the guidelines of WHO (World Health Organization) Classification for malignant hemopathies, with the aim of identifying distinct genetic-pathological entities. Our approach is based on restriction mapping of euchromatic and centric/pericentric regions involved in structural rearrangements by using FISH and molecular investigations such as RACE-PCR, and RT-PCR for candidate genes. Moreover we perform mutational analysis by both direct sequencing and DHPLC. We apply our mutational analysis in all cases with normal or failed karyotype, in cases with already known critical mutations, as well as checking for mutations of candidate genes regulating phenotypic features of leukemia subgroups. In order to identify early and aggressive genomic lesions in hematological malignancies we selected two different conditions. One of them is the B clonal lymphoproliferation arising in subjects with a hepatitis C virus infection which is emerging as an interesting model of B lymphomagenesis. Through the identification of clonal aberrations in sequential studies during the follow up of patients, we intend to trace critical steps of malignant transformation leading to a low grade lymphoma, such as marginal zone lymphoma in HCV-infected patients. As far as it concerns the significance of clonality in the context of a myelodyplastic bone marrow we will focus on two conditions: a long-lasting MDS, such as cytopenia with unilineage dysplasia, and the bone marrow insufficiency in Shwachman syndrome which may precede true MDS. We also use a FISH approach to develop new diagnostic tests for leukemic rearrangements by identifying and cloning new genes from rare chromosome rearrangements.
 
 
 
  TECNOLOGIE IN POSSESSO DELL'U. O.  
 
   
 
  • Conventional Cytogenetics
  • Interphase and Metaphase FISH
  • Multicolor FISH
  • Comparative Genomic Hybridization (CGH)
  • Microarray CGH
  • Mutational analysis: DHPLC and sequencing
  • Production and validation of genomic FISH probes
  • Single cell pheno-genotyping (FICTION)
  • Gene cloning
  • Affymetrix tecnology (SNPs)
  • PCR, RT-PCR, RACE-PCR, quantitative PCR
 
 
 
  STRUMENTAZIONE    
 
   
 
Denominazione
Struttura ove la strumentazione è allocata
Responsabile della strumentazione
Karyotyping Systems, Vysis,Metasystem, Applied Imaging
Laboratory of Cytogenetics and Molecular Genetics Hematology University of Perugia
Cristina Mecucci
MultiFISH, Metasystem
Laboratory of Cytogenetics and Molecular Genetics Hematology University of Perugia
Cristina Mecucci
2 Olympus Fluorescence Microscope
Laboratory of Cytogenetics and Molecular Genetics Hematology University of Perugia
Cristina Mecucci
1 Zeiss Fluorescence Microscope
Laboratory of Cytogenetics and Molecular Genetics Hematology University of Perugia
Cristina Mecucci
Microarray Scanner AXON B4000
Laboratory of Cytogenetics and Molecular Genetics Hematology University of Perugia
Cristina Mecucci
CGH, Vysis and Applied Imaging
Laboratory of Cytogenetics and Molecular Genetics Hematology University of Perugia
Cristina Mecucci
DHPLC Transgenomic
Laboratory of Cytogenetics and Molecular Genetics Hematology University of Perugia
Cristina Mecucci
Cell Sorter, Becton Dickinson
Laboratory of Immunology
Andrea Velardi
Affymetrix  Laboratory of Cytogenetics and Molecular Genetics Hematology University of Perugia Cristina Mecucci 
LightCycler 480 II, Roche (Real-Time PCR) Laboratory of Cytogenetics and Molecular Genetics Hematology University of Perugia Cristina Mecucci
 
 
 
  PUBBLICAZIONI    
 
   
 

1. La Starza R, Aventin A, Falzetti D, Wlodarska I, Fernandez Peralta AM, Gonzales-Aguilera JJ, Ciolli S, Martelli MF, Mecucci C. Regions of juxtaposition in unbalanced 1q rearrangements of malignant hemopathies. Leucemia.2001 May;15(5): 861-863.
2. Rosati R, La Starza R,Veronese A, Aventin A, Schwienbacher C, Vallespi T, Negrini M, Martelli MF, Mecucci C. NUP98 is fused to the NSD3 gene in acute myeloid leukemia associated with t(8;11)(p11.2;p15). Blood. 2002 May 15; 99(10): 3857-3860. IF 8,782
3. Crescenzi B, Sacchi S, Marasca R, Temperani P, La Starza R, Matteucci C, Bonacorsi G, Romoli S, Martelli MF, Mecucci C, Emilia G. Distinct genomic events in the myeloid and lymphoid lineages in simultaneous presentation of chronic myeloid leukemia and B-chronic lymphocytic leukemia. Leukemia. 2002 May;16(5): 955-956.
4. La Starza R, Trubia M, Testoni N, Ottaviani E, Belloni E, Crescenzi B, Martelli MF, Flandrin G, Pelicci PG, Mecucci C. Clonal eosinophils are a morphological hallmark of ETV6/ABL1 positive acute myeloid leukemia. Haematologica. 2002 Aug; 87:789-794.
5. La Starza R, Trubia M, Crescenzi B, Matteucci C, Negrini M, Martelli MF, Pelicci PG, Mecucci C. Related Articles, Links C. Human homebox gene HOXC13 is the partner of NUP98 in adult acute myeloid leukemia with t(11;12)(p15;q13) Genes Chromosome Cancer 2003 Apr;36(4):420-3
6. Matteucci C, Galieni P, Leoncini L, Lazzi S, Lauria F, Polito E, Martelli MF, Mecucci C. Typical genomic imbalances in primary MALT lymphoma of the orbit J Pathol. 2003 Aug;200(5):656-60
7. La Starza R, Gorello P, Rosati R, Riezzo A, Veronese A, Ferrazzi E, Martelli MF, Negrini M, Mecucci C. Cryptic insertion producing two NUP98/NSD1 chimeric transcript in adult refractory anemia with an excess of blasts. Genes Chromosomes Cancer 2004 Dec; 41(4):395-9

8. Mancini M, Scappaticci D, Cimino G, Nanni M, Derme V, Elia L, Tafuri A, Vignetti M, Vitale A, Cuneo A, Castoldi G, Saglio G, Pane F, Mecucci C, Camera A, Specchia G, Tedeschi A, Di Raimondo F, Fioritoni G, Fabbiano F, Marmont F, Ferrara F, Cascavilla N, Todeschini G, Nobile F, Kropp MG, Leoni P, Tabilio A, Luppi M, Annino L, Mandelli F, Foa R. A comprehensive genetic classification of adult acute lymphoblastic leukemia (ALL): analysis of the GIMEMA 0496 protocol. Blood 2005 May 1; 105(9):3434-41

9. Falini B, Mecucci C, Tiacci E, Alcalay M, Rosati R, Pasqualucci L, La Starza R, Diverio D, Colombo E, Santucci A, Bigerna B, Pacini R, Pucciarini A, Liso A, Vignetti M, Fazi P, Meani N, Pettirossi V, Saglio G, Mandelli F, Lo Coco F, Pelicci PG, Martelli MF, GIMEMA Acute Leukemia Working Party. Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype. N Engl J Med 2005 Jan 20;352(3):254-66

10. Pane F, Cimino G, Izzo B, Camera A, Vitale A, Quintarelli C, Picardi M, Specchia G, Mancini M, Cuneo A, Mecucci C, Martinelli G, Saglio G, Rotoli B, Mandelli F, Salvatore F, Foa R, GIMEMA group. Significant reduction of the hybrid BCR/ABL transcript after induction and consolidation therapy is a powerful predictor of treatment response in adult Philadelphia-positive acute lymphoblastic leukemia. Leukemia 2005 Apr;19(4):628-35

11. Aversa F, Terenzi A, Tabilio A, Falzetti F, Carotti A, Ballanti S, Felicini R, Falcinelli F, Velardi A, Ruggeri L, Aloisi T, Saab JP, Santucci A, Perruccio K, Martelli MP, Mecucci C, Reisner Y, Martelli MF. Full haplotype-mismatched hematopoietic stem-cell transplantation: a phase II study in patients with acute leukemia at high risk of relapse. J Clin Oncol 2005 May 20;23(15):3447-54

12. Corveleyn A, Wlodarska I, Mecucci C, Marynen P. The der(12)t(12;16) breakpoint in an acute leukemia case targets a Sec7 domain containing protein. Int J Oncol 2005 Apr;26(4):1111-20

13. Alcalay M, Tiacci E, Bergomas R, Bigerna B, Venturini E, Minardi SP, Meani N, Diverio D, Bernard L, Tizzoni L, Volorio S, Luzi L, Colombo E, Lo Coco F, Mecucci C, Falini B, Pelicci PG. Acute myeloid leukemia bearing cytoplasmic nucleophosmin (NPMc+ AML) shows a distinct gene expression profile characterized by up-regulation of genes involved in stem-cell maintenance. Blood 2005 Aug1;106(3):899-902

14. Cazzaniga G, Dell’Oro MG, Mecucci C, Giarin E, Masetti R, Rossi V, Locatelli F, Martelli MF, Basso G, Pession A, Biondi A, Falini B. Nucleophosmin mutations in childhood acute myelogenous leukemia with normal karyotype. Blood 2005 Aug 15;106(4):1419-22

15. La Starza R, Specchia G, Cuneo A, Beacci D, Nozzoli C, Luciano L, Aventin A, Sambani C, Testoni N, Foppoli M, Invernizzi R, Marynen P, Martelli MF, Mecucci C. The hypereosinophilic syndrome: fluorescence in situ hybridization detects the del(4)(q12)-FIP1L1/PDGFRA but not genomic rearrangements of other tyrosine kinases. Haematologica 2005 May;90(5):596-601

16. Noguera NI, Ammatuna E, Zangrilli D, Lavorgna S, Divona M, Buccisano F, Amadori S, Mecucci C, Falini B, Lo Coco F. Simultaneous detection of NPM1 and FLT3-ITD mutations by capillary electrophoresis in acute myeloid leukemia. Leukemia 2005 Aug;19(8):1479-82.

17. La Starza R, Aventin A, Crescenzi B, Gorello P, Specchia G, Cuneo A, Angioni A, Bilhou-Nabera C, Boque C, Foa R, Uyttbroeck A, Talmant P, Cimino G, Martelli MF, Marynen P, Mecucci C, Hagemeijer A. CIZ gene rearrangement in acute leukemia: report of a diagnostic FISH assay and clinical features of nine patients. Leukemia 2005 Jun 30 Leukemia. 2005 Sep;19(9):1696-9.

18. Roti G, La Starza R, Gorello P, Gottardi E, Crescenzi B, Martelli MF, Mecucci C. e6a2 BCR/ABL fusion with criptic der (9)t(9;22) deletions in a patient with chronic myeloid leukemia. Haematologica, Aug 2005; 90(8): 1139-41.

19. Quentmeier H, Martelli MP, Dirks WG, Bolli N, Liso A, MacLeod RA, Nicoletti I, Mannucci R, Pucciarini A, Bigerna B, Martelli MF, Mecucci C, Drexler HG, Falini B. Cell line OCI/AML3 bears exon-12 NPM gene mutation-A and cytoplasmic expression of nucleophosmin. Leukemia, Aug 2005 Leukemia. 2005 Oct;19(10):1760-7.

20. Schnittger S, Schoch C, Kern W, Mecucci C, Tschulik C, Martelli MF, Haferlach T, Hiddemann W, Falini B. Nucleophosmin gene mutations are predictor of favourable prognosis in acute myelogenous leukemia with normal karyotype. Blood, 2005 Dec 1;106(12):3733-9.

21. Sambani C, La Starza R, Pierini V, Vandenberghe P, Gonzales-Aguilera JJ, Rigana H, Koumbi D, Kalliopi N, Manoa C, Stavropoulou C, Georgakakos VN, Pagoni M, Wlodarska I, Mecucci C. Leukemic recombinations involving heterochromatin in myeloproliferative disorders with t(1;9). Cancer Genet Cytogenet 2005 Oct 1;162(1):45-9.

22. Vitale A, Guarini A, Ariola C, Mancini M, Mecucci C, Cuneo A, Pane F, Saglio G, Cimino G, Tafuri A, Meloni G, Fabbiano F, Recchia A, Kropp MG, Krampera M, Cascavilla N, Ferrara F, Romano A, Mazza P, Fozza C, Paoloni F, Vignetti M, Foà R. Adult T-cell acute lymphoblastic leukemia: biologic profile at presentation and correlation with response to induction treatment in patients enrolled in the GIMEMA LAL 0496 protocol. Blood, 2006 Jan 15;107(2):473-9.

23. Falini B, Bigerna B, Pucciarini A, Tiacci E, Mecucci C, Morris SW, Bolli N, Rosati R, Hanissian S, Ma Z, Sun Y, Colombo E, Arber DA, Pacini R, La Starza R, Galletti BV, Liso A, Martelli MP, Diverio D, Pelicci PG, Coco FL, Martelli MF. Aberrant subcellular expression of nucleophosmin and NPM-MLF1 fusion protein in acute myeloid leukaemia carrying t(3;5):A comparison with NPMc+ AML. Leukemia, 2006 Feb; 20(2):368-371.

24. Maserati E, Minelli A, Pressato B, Valli R, Crescenzi B, Stefanelli M, Menna G, Sainati L, Poli F, Panarello C, Zecca M, Curto FL, Mecucci C, Danesino C, Pasquali F. Shwachman sindrome as mutator phenotype responsible for myeloid displasia/neoplasia through karyotype instability and chromosomes 7 and 20 anomalies. Genes Chromosomes Cancer, 2006 Apr;45(4):375-382.

25. Van Zutven LJ, Onen E, Velthuizen SC, Van Drunen E, Von Bergh AR, Van den Heuvel-eibrink MM, Veronese A, Mecucci C, Negrini M, de Greef GE, Beverloo HB. Identification of NUP98 abnormalities in acute leukaemia: JARID1A (12p13) as a new partner gene. Genes Chromosomes Cancer 2006 May;45(5):437-446.

26. Falini B, Bolli N, Shan J, Martelli MP, Liso A, Pucciarini A, Bigerna B, Pasqualucci L, Mannucci R, Rosati R, Gorello P, Diverio D, Roti G, Tiacci E, Cazzaniga G, Biondi A, Schnittger S, Haferlach T, Hiddemann W, Martelli MF, Gu W, Mecucci C, Nicoletti I. Both carboxy-terminus NES motif and mutated tryptophan(s) are crucial for aberrant nuclear export of nucleophosmin leukemic mutants in NPMc+AML. Blood, 2006 Jun 1;107(11):4514-23.

27. Cimino G, Pane F, Elia L, Finolezzi E, Fazi P, Annino L, Meloni G, Mancini M, Tedeschi A, Di Raimondo F, Specchia G, Fioritoni G, Leoni P, Cuneo A, Mecucci C, Saglio G, Mandelli F, Foà R. The role of BCR/ABL isoforms in the presentation and outcome of patients with Philadelphia-positive acute lymphoblastic leucemia: a seven-year update of the GIMEMA 0496 trial. Haematologica 2006; 91(3):377-380.

28. Gorello P, Cazzaniga G, Alberti F, Dell’Oro MG, Gottardi E, Specchia G, Roti G, Rosati R, Martelli MF, Diverio D, Coco FL, Biondi A, Saglio G, Mecucci C, Falini B. Quantitative assessment of minimal residual disease in acute myeloid leukemia carrying nucleophosmin (NPM1) gene mutations. Leukemia, 2006 Jun;20(6):1103-08.

29. Bolli N, Galimberti S, Martelli MP, Tabarrini A, Roti G, Mecucci C, Martelli MF, Petrini M, Falini B. Cytoplasmic nucleophosmin in myeloid sarcoma occurring 20 years after diagnosis of acute myeloid leukemia. Lancet Oncology, 2006 Apr;7(4):350-2.

30. La Starza R, Aventin A, Matteucci C, Crescenzi B, Romoli S, Testoni N, Pierini V, Ciolli S, Sambani C, Locasciulli A, Di Bona E, Lafage-Pochitaloff M, Martelli MF, Marynen P, Mecucci C. Genomic gain at 6p21: a new cryptic molecular rearrangement in secondary myelodysplastic sindrome and acute myeloid leukemia. Leukemia, 2006 Jun;20(6):958-64.

31. Trubia M, Albano F, Cavazzini F, Rege Cambrin G, Quarta G, Fabbiano F, Ciambelli F, Magro D, Hernandez JM, Mancini m, Diverio D, Pelicci PG, Lo Coco F, Mecucci C, Specchia G, Rocchi M, Liso V, Castoldi G, Cuneo A. Characterization of a recurrent translocation t(2;3)(p15-p22;q26) occurring in acute myeloid leukaemia. Leukemia, 2006 Jan;20(1):48-54.

32. Roti G, La Starza R, Ballanti S, Crescenzi B, Romoli S, Foa R, Tartaglia M, Aversa F, Martelli MF, Mecucci C. Acute lymphoblastic leukemia in Noonan sindrome. British Journal of Haematology, 2006 May;133(4):448-50.

33. Roti G, Rosati R, Bonasso R, Gorello P, Diverio D, Martelli MF, Falini B, Mecucci C; Gruppo Italiano Malattie Ematologiche dell’Adulto Working Party. Denaturing high-performance liquid chromatography: a valid approach for identifying NPM1 mutations in acute myeloid leukemia. Journal of Molecular Diagnostics, 2006 May;8(2):254-9.

34. La Starza R, Barba G, Matteucci C, Crescenzi B, Romoli S, Pierini V, Beacci D, Cantaffa R, Martelli MF, MecucciC. Chronic lymphocytic leucemia . Is terminal del(14)(q24) a new marker for prognostic stratification? Leukemia research, 2006 Dec;30(12):1569-72.

35. Falini B, Martelli MP, Bolli N, Bonasso R, Ghia E, Pallotta MT, Diverio D, Nicoletti I, Pacini R, Tabarrini A, Verducci Galletti B, Mannucci R, Roti G, Rosati R, Specchia G, Liso A, Tiacci E, Alcalay M, Luzi L, Volorio S, Bernard L, Guarini A, Amadori S, Mandelli F, Pane F, Lo Coco F, Saglio G, Pelicci PG, Martelli MF, Mecucci C. Immunohistochemistry predicts nucleophosmin (NPM) mutations in acute myeloid leukemia. Blood, 2006 Sep15;108(6):1999-2005.

36. Janssen H, Wlodarska I, Mecucci C, Hagemeijer A, Vandenberghe P, Maryen P, Cools J. Fusion of ETV6 to GOT1 in a case with myelodysplastic syndrome and t(10;12)(q24;p13). Haematologica, 2006;91:949-951.

37. Grisendi S, Mecucci C, Falini B, Pandolfi PP. Nucleophosmin and cancer. Nat Rev Cancer. 2006 Jul;6(7):493-505.

38. Rosati R, La Starza R, Luciano L, Gorello P, Matteucci C, Pierini V, Romoli S, Crescenzi B, Rotoli B, Martelli MF, Pane F, Mecucci C. TPM3/PDGFRB fusion transcript and its reciprocal in chronic eosinophilic leukemia. Leukemia. 2006;20:1623-1624.

39. La Starza R, Crescenzi B, Krause A, Pierini V, Specchia G, Bardi A, Nieddu R, Ariola C, Nanni M, Diverio D, Aventin A, Sborgia M, Martelli MF, Bohlander SK, Mecucci C. Dual-color split signal fluorescence in situ hybridization assays for the detection of CALM/AF10 in t(10;11)(p13;q14-q21)-positive acute leukemia. Haematologica. 2006;91:1248-1251.

40. Pasqualucci L, Liso A, Martelli MP, Bolli N, Pacini R, Tabarrini A, Carini M, Bigena B, Pucciarini A, Mannucci R, Nicoletti I, Tiacci E, Meloni G, Specchia G, Cantore N, Di Raimondo F, Pileri S, Mecucci C, Mandelli F, Martelli MF, Falini B. Mutated nucleophosmin detects clonal multilineage involvement in acute myeloid leukemia: Impact on WHO classification. Blood. 2006 Dec 15;108(13):4146-55

41. Di Noto R, Mirabelli P, Mariotti E, Sacchetti L, Pane F, Rotoli B, Pardo CL, Vecchio LD, Mecucci C, Salvatore F. CMRL-T, a novel T-cell line showing asynchronous phenotype (CD34+/CD1a-/TCRalphabeta+) and dual T-cell receptor beta chain. Leukemia. 2006 Dec;20(12):2175-2177.

42. Deshpande AJ, Cusan M, Rawat VP, Reuter H, Krause A, Pott C, Quintanilla-Martinez L, Kakadia P, Kuchenbauer F, Ahmed F, Delabesse E, Hahn M, Lichter P, Kneba M, Hiddemann W, Macintyre E, Mecucci C, Ludwig WD, Humphries RK, Bohlaner SK, Feuring-Buske M, Buske C. Acute myeloid leukemia is propagated by a leukemic stem cell with lymphoid characteristics in a mouse model of CALM/AF10-positive leukemia. Cancer Cell. 2006 Nov;10(5):363-74.

43. Rosati R, La Starza R, Barba G, Gorello P, Pierini V, Matteucci C, Roti G, Crescenzi B, Romoli S, Aloisi T, Aversa F, Martelli MF, Mecucci C. Cryptic chromosome 9q34 deletion generates TAF-Ialpha/CAN and TAF-Ibeta/CAN fusion transcripts in acute myeloid leukemia. Haematologica. 2007 Feb;92(2):232-5.

44. Falini B, Nicoletti I, Martelli MF, Mecucci C. Acute myeloid leukemia carrying cytoplasmic/mutated nucleophosmin (NPMc+ AML): biological and clinical features. Blood. 2007 Feb;109(3):874-85.

45. Crescenzi B, Chase A, Starza RL, Beacci D, Rosti V, Galli A, Specchia G, Martelli MF, Vandenberghe P, Cools J, Jones AV, Cross NC, Marynen P, Mecucci C. FIP1L1-PDGFRA in chronic eosinophilic leukemia and BCR-ABL1 in chronic myeloid leukemia affect different leukemic cells. Leukemia. 2007 Mar; 21(3):397-402

46. Etienne A, Gelsi-Boyer V, Carbuccia N, Adelaide J, Barba G, La Starza R, Murati A, Eclache V, Birg F, Birnbaum D, Mozziconacci MJ, Mecucci C, Chaffanet M. Combined translocation with ZNF198-FGFR1 gene fusion and deletion of potential tumor suppressors in a myeloproliferative disorder. Cancer Genet Cytogenet. 2007 Mar;173(2):154-8.

47. La Starza R, Rosati R, Roti G, Gorello P, Bardi A, Crescenzi B, Pierini V, Calabrese O, Baens M, Folens C, Cools J, Marynen P, Martelli MF, Mecucci C, Cuneo A. A new NDE1/PDGFRB fusion transcript underlying chronic myelomonocytic leukaemia in Noonan Syndrome. Leukemia. 2007 Apr;21(4):830-3.

48. Falini B, Nicoletti I, Bolli N, Martelli MP, Liso A, Gorello P, Mandelli F, Mecucci C, Martelli MF. Translocations and mutations involving the nucleophosmin (NPM1) gene in lymphomas and leukemias. Haematologica. 2007 Apr;92(4):519-32.

49. Chiaretti S, Tavolato S, Ghia EM, Ariola C, Matteucci C, Elia L, Maggio R, Messina M, Ricciardi MR, Vitale A, Ritz J, Mecucci C, Guarini A, Foa R. Characterization of ABL1 expression in adult T-cell acute lymphoblastic leucemia by oligonucleotide array analysis. Haematologica. 2007 May;92(5):619-26.

50. La Starza R, Crescenzi B, Pierini V, Romoli S, Gorello P, Brandimarte L, Matteucci C, Kropp MG, Barba G, Martelli MF, Mecucci C.A common 93-kb duplicated DNA sequenze at 1q21.2 in acute lymphoblatsic leucemia and Burkitt lymphoma. Cancer Genet Cytogenet. 2007 May;175(1):73-6.

51. Crescenzi B, La Starza R, Nozzoli C, Ciolli S, Matteucci C, Romoli S, Rigacci L, Gorello P, Bosi A, Martelli MF, Marynen P, Mecucci C. Molecular cytogenetic findings in a four-way t(1;12;5;12)(p36;p13;q33;q24) underlying the ETV6-PDGFRB fusion gene in chronic myelomonocytic leukemia. Cancer Genet Cytogenet. 2007 Jul 1;176(1):67-71.

52. Bolli N, Nicoletti I, De Marco MF, Bigerna B, Pucciarini A, Mannucci R, Martelli MP, Liso A, Mecucci C, Fabbiano F, Martelli MF, Henderson BR, Falini B. Born to be exported: COOH-terminal nuclear export signals of different strength censure cytoplasmic accumulation of nucleophosmin leukemic mutants. Cancer Res. 2007 Jul 1;67(13):6230-7.

53. Zhang L, Alsabeh R, Mecucci C, La Starza R, Gorello P, Lee S, Lill M, Schreck R. Rare t(1;11)(q23;p15) in therapy-related myelodysplastic syndrome evolving into acute myelomonocytic leukemia: a case report and review of the literature. Cancer Genet Cytogenet. 2007 Oct 1;178(1):42-8.

54. Shing DC, Trubia M, Marchesi F, Radaelli E, Belloni E, Tapinassi C, Scanzini E, Mecucci C, Crescenzi B, Lahortiga I, Odero MD, Zardo G, Gruszka A, Minucci S, Di Fiore PP, Pelicci PG. Overexpression of sPRDM16 coupled with loss of p53 induces myeloid leukemias in mice. J Clin Invest. 2007 Dec;117(12):3696-707.

55. Gorello P, La Starza R, Brandimarte L, Trisolini SM, Pierini V, Crescenzi B, Limongi MZ, Nanni M, Belloni E, Tapinassi C, Gerbino E, Martelli MF, Foa R, Meloni G, Mecucci C. A PDGFRB-positive acute myeloid malignancy with a new t(5;12)(q33;p13.3) involving the ERC1 gene. Leukemia. 2008 Jan;22(1):216-8 [2007 Aug 9; Epub ahead of print].

56. Matteucci C, Bracci M, Barba G, Carbonari M, Casato M, Visentini M, Pulsoni A, Varasano E, Roti G, Starza RL, Crescenzi B, Martelli MF, Fiorilli M, Mecucci C. Different genomic imbalances in low- and high- grade HCV-related lymphomas. Leukemia. 2008 Jan;22(1):219-22 [2007 Aug 9; Epub ahead of print].

57. Falini B, Mecucci C, Saglio G, Lo Coco F, Diverio D, Brown P, Pane F, Mancini M, Martelli MP, Pileri S, Haferlach T, Haferlach C, Schnittger S. NPM1 mutations and cytoplasmic nucleophosmin are mutually exclusive of recurrent genetic abnormalities: a comparative analysis of 2562 patients with acute myeloid leukemia. Haematologica. 2008 Mar;93(3):439-42.

58. Garzon R, Garofalo M, Martelli MP, Briesewitz R, Wang L, Fernandez-Cymering C, Volinia S, Liu CG, Schnittger S, Haferlach T, Liso A, Diverio D, Mancini M, Meloni G, Foa R, Martelli MF, Mecucci C, Croce CM, Falini B. Distinctive microRNA signature of acute myeloid leukemia bearing cytoplasmic mutated nucleophosmin. Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3945-50.

59. Jankovic D, Gorello P, Liu T, Ehret S, La Starza R, Desjobert C, Baty F, Brutsche M, Jayaraman PS, Santoro A, Mecucci C, Schwaller J. Leukemogenic mechanisms and targets of NUP98/HHEX fusion in acute myeloid leukemia (AML). Blood. 2008 Jun 15;111(12):5672-82.

60. Falini B, Martelli MP, Mecucci C, Liso A, Bolli N, Bigerna B, Pucciarini A, Pileri S, Meloni G, Martelli MF, Haferlach T, Schnittger S. Cytoplasmic mutated nucleophosmin is stable in primary leukemic cells and in a xenotransplant model of NPMc+ acute myeloid leukemia in SCID mice. Haematologica. 2008 May;93(5):775-9

61. Lo-Coco F, Cuneo A, Pane F, Cilloni D, Diverio D, Mancini M, Testoni N, Bardi A, Izzo B, Bolli N, La Starza R, Fazi P, Iacobelli S, Piciocchi A, Vignetti M, Amadori S, Mandelli F, Pelicci PG, Mecucci C, Falini B, Saglio G, for the Acute Leukemia Working Party of the GIMEMA group. Prognostic impact of genetic characterization in the GIMEMA LAM99P multicenter study for newly diagnosed acute myeloid leukemia Haematologica. 2008 Jul;93(7):1017-24. [Epub 2008 May 27]

62. Barba G, Matteucci C, Girolomoni G, Brandimarte L, Varasano E, Martelli MF, Mecucci C. Comparative genomic hybridization identifies 17q11.2 approximately q12 duplication as an early event in cutaneous T-cell lymphomas. Cancer Genet Cytogenet. 2008 Jul;184(1):48-51.

63. Florida G, Falbo V, Censi F, Tosto F, Salvatore M, Baroncini A, Battaglia P, Conti A, Donti E, La Starza R, Nitsch L, Pierluigi M, Piombo G, Susca F, Mancini M, Mecucci C, Calzolari E, Dagna Bricarelli F, Guanti G, Taruscio D. The Italian external quality assessment scheme in classical cytogenetics: four years of activity. Community Genet. 2008;11(5):295-303. [Epub 2008 May 20].

64. Gorello P, Gorello P, Brandimarte L, La Starza R, Pierini V, Bury L, Rosati R, Martelli MF, Vandenberghe P, Wlokarska I, Mecucci C. t(3;11)(q12;p15)/NUP98-LOC348801 fusion transcript in acute myeloid leukemia. Haematologica. 2008 Sep ; 93(9) : 1398-401, [Epub 2008 Jul 4]

65. Aventín A, Sánchez J, Nomdedéu JF, Estany C, Forcada P, La Starza R, Mecucci C. Novel IGHalpha translocations, t(2;14)(q14.3;q32) and t(14;17)(q32;q21), in B-cell precursor acute lymphoblastic leukemia. Cancer Genet Cytogenet. 2008 Aug;185(1):57-9.

66. Bousquet M, Quelen C, Rosati R, Mansat-De Mas V, La Starza R, Bastard C, Lippert E, Talmant P, Lafage-Pochitaloff M, Leroux D, Gervais C, Viguié F, Lai JL, Terre C, Beverlo B, Sambani C, Hagemeijer A, Marynen P, Delsol G, Dastugue N, Mecucci C, Brousset P. Myeloid cell differentiation arrest by miR-125b-1 in myelodysplastic syndrome and acute myeloid leukemia with the t(2;11)(p21;q23) translocation. J Exp Med. 2008 Oct 27;205(11):2499-506. [Epub 2008 Oct 20].

67. Morra E, Barosi G, Bosi A, Ferrara F, Locatelli F, Marchetti M, Martinelli G, Mecucci C, Vignetti M, Tura S. Clinical management of primary non-acute promyelocytic leukemia acute myeloid leukemia: practice Guidelines by the Italian Society of Hematology, the Italian Society of Experimental Hematology and the Italian Group for Bone Marrow Transplantation. Haematologica. 2009 Jan; 94(1): 102-12. [Epub 2008 Nov 10]

68. Crescenzi B, La Starza R, Sambani C, Parcharidou A, Pierini V, Nofrini V, Brandimarte L, Matteucci C, Aversa F, Martelli MF, Mecucci C. Totipotent stem cells bearing del(20q) maintain multipotential differentiation in Shwachman Diamond syndrome. Br J Haematol. 2009 Jan; 144(1): 116-9. [Epub 2008 Nov 11].

69. Roberti MC, La Starza R, Surace C, Sirleto P, Pinto RM, Pierini V, Crescenzi B, Mecucci C, Angioni A. RABGAP1L gene rearrangement resulting from a der(Y)t(Y;1)(q12;q25) in acute myeloid leukemia arising in a child with Klinefelter syndrome. Virchows Arch. 2009 Mar;454(3):311-6. [Epub 2009 Jan 28].

70. Haferlach C, Mecucci C, Schnittger S, Kohlmann A, Mancini M, Cuneo A, Testoni N, Rege-Cambrin G, Santucci A, Vignetti M, Fazi P, Martelli MP, Haferlach T, Falini B. AML with mutated NPM1 carrying a normal or aberrant karyotype show overlapping biological, pathological, immunophenotypic, and prognostic features. Blood. 2009 Oct 1;114(14):3024-32. [Epub 2009 May 8].

71. La Starza R, Brandimarte L, Pierini V, Nofrini V, Gorello P, Crescenzi B, Berchicci L, Matteucci C, Romoli S, Beacci D, Rosati R, Martelli MF, Mecucci C. A NUP98-positive acute myeloid leukemia with a t(11;12)(p15;q13) without HOXC cluster gene involvement. Cancer Genet Cytogenet. 2009 Sep;193(2):109-11.

72. Cavazzini F, Bardi A, Ciccone M, Rigolin GM, Gorello P, La Starza R, Mecucci C, Cuneo A. Trisomy 8 in PDGFRB-negative cells in a patient with imatinib-sensitive chronic myelomonocytic leukemia and t(5;16)(q33;p13), PDGFRB-NDE1 fusion. Cancer Genet Cytogenet. 2009 Oct;194(1):67-9.

73. Gorello P, La Starza R, Varasano E, Chiaretti S, Elia L, Pierini V, Barba G, Brandimarte L, Crescenzi B, Vitale A, Messina M, Grammatico S, Mancini M, Matteucci C, Bardi A, Guarini A, Martelli MF, Foà R, Mecucci C. Combined interphase fluorescence in situ hybridization elucidates the genetic heterogeneity of T-cell acute lymphoblastic leukemia in adults. Haematologica. 2010 Jan;95(1):79-86.

74. Matteucci C, Barba G, Varasano E, Vitale A, Mancini M, Testoni N, Cuneo A, Rege-Cambrin G, Elia L, La Starza R, Pierini V, Brandimarte L, Vignetti M, Foà R, Mecucci C; for the GIMEMA Acute Leukaemia Working Party, Italy. Rescue of genomic information in adult acute lymphoblastic leukaemia (ALL) with normal/failed cytogenetics: a GIMEMA centralized biological study. Br J Haematol. 2010 Apr;149(1):70-8.

75. Falini B, Martelli MP, Pileri SA, Mecucci C. Molecular and alternative methods for diagnosis of acute myeloid leukemia with mutated NPM1: flexibility may help. Haematologica. 2010 Apr;95(4):529-34.

76. Sportoletti P, Baldoni S, Cavalli L, Del Papa B, Bonifacio E, Ciurnelli R, Bell AS, Di Tommaso A, Rosati E, Crescenzi B, Mecucci C, Screpanti I, Marconi P, Martelli MF, Di Ianni M, Falzetti F. NOTCH1 PEST domain mutation is an adverse prognostic factor in B-CLL. Br J Haematol. 2010 Nov;151(4):404-6.

77. GorelloP, La Starza R, Di Giacomo D, Messina M, Puzzolo MC, Crescenzi B, Santoro A, Chiaretti S, Mecucci C. SQSTM1-NUP214: A new gene fusion in adult T-cell acute lymphoblastic leukemia. Haematologica. 2010 Dec;95(12):2161-3.

78. Savage NM, Kota V, Manaloor EJ, Kulharya AS, Pierini V, Mecucci C, Ustun C. Acute leukemia with PICALM-MLLT10 fusion gene: diagnostic and treatment struggle. Cancer Genet Cytogenet. 2010 Oct 15;202(2):129-32.

79. La Starza R, Matteucci C, Gorello P, Brandimarte L, Pierini V, Crescenzi B, Nofrini V, Rosati R, Gottardi E, Saglio G, Santucci A, Berchicci L, Arcioni F, Falini B, Martelli MF, Sambani C, Aventin A, Mecucci C. NPM1 Deletion is Associated with Gross Chromosomal Rearrangements in Leukemia. PLoSONE 2010 Sep 21;5(9):e12855.

 

 
 
 
  DOTTORATI DI RICERCA    
 
   
 
Componente U.O. Dottorato di Ricerca Coordinatore Sede
Mecucci Cristina
Biotecnologie nel trapianto di midollo osseo umano
Falini B
Università di Perugia
Velardi Andrea
Biotecnologie nel trapianto di midollo osseo umano
Falini B
Università di Perugia
       
 
 
 
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Congressi Partecipazione
CNB4
 
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CNB5
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CNB6
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CNB7
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CNB8
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CNB9 X
CNB10