Direzione e uffici C.I.B.

Direzione CIB:
Prof. Claudio Schneider
Email: claudio.schneider@Lncib.it

Segreteria CIB:
Prof. Roberto Gambari
Email: roberto.gambari@unife.it

SEGRETERIA ORGANIZZATIVA:
Elisabetta Lambertini
Tel: 0532/974451
Fax: 0532/974484
E-mail: lmblbt@unife.it

AMMINISTRAZIONE:
Vanessa Florit
Area di Ricerca
Padriciano, 99 - 34012 Trieste
Tel: 040/398979
Fax: 040/398990
E-mail: cib@lncib.it

Posta certificata C.I.B.:
cib@poste-certificate.it

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Ottonello Simone Stampa
RESPONSABILE DELLA U. O.

Cognome e Nome
Ottonello Simone
Qualifica
Professore Ordinario
Facoltà
Dipartimento

Scienze Chimiche, della Vita e della Sostenibilità Ambientale

Settore Scientifico Disciplinare BIO/11
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PERSONALE STRUTTURATO

Cognome e Nome
OTTONELLO Simone
Qualifica
PO
Dipartimento

Scienze Chimiche, della Vita e della Sostenibilità Ambientale

Ente di appartenenza
Università degli Studi di Parma
Cognome e Nome
BOLCHI Angelo
Qualifica
PA
Dipartimento

Scienze Chimiche, della Vita e della Sostenibilità Ambientale

Ente di appartenenza
Università degli Studi di Parma
Cognome e Nome DIECI Giorgio
Qualifica

PO-Direttore di Dipartimento

Dipartimento Scienze Chimiche, della Vita e della Sostenibilità Ambientale

 

Ente di appartenenza
Università degli Studi di Parma
Cognome e Nome MONTANINI Barbara
Qualifica PA
Dipartimento Scienze Chimiche, della Vita e della Sostenibilità Ambientale
Ente di appartenenza Università degli Studi di Parma
Cognome e Nome CAVAZZINI Davide
Qualifica Funzionario tecnico, PhD
Dipartimento Scienze Chimiche, della Vita e della Sostenibilità Ambientale
Ente di appartenenza Università degli Studi di Parma
Cognome e Nome LEVATI Elisabetta
Qualifica Funzionario tecnico, PhD
Dipartimento Scienze Chimiche, della Vita e della Sostenibilità Ambientale
Ente di appartenenza Università degli Studi di Parma

PERSONALE NON STRUTTURATO

Cognome e Nome SPAGNOLI Gloria
Qualifica Assegnista di Ricerca
Dipartimento Scienze Chimiche, della Vita e della Sostenibilità Ambientale
Ente di appartenenza Università degli Studi di Parma
Cognome e Nome SARTINI Sara
Qualifica Borsista
Dipartimento Scienze Chimiche, della Vita e della Sostenibilità Ambientale


Ente di appartenenza Università degli Studi di Parma
Cognome e Nome GARRAPA Valentina
Qualifica Dottoranda
Dipartimento Scienze Chimiche, della Vita e della Sostenibilità Ambientale
Ente di appartenenza Università degli Studi di Parma
Cognome e Nome MINATO Ilaria
Qualifica Dottoranda
Dipartimento Scienze Chimiche, della Vita e della Sostenibilità Ambientale
Ente di appartenenza Università degli Studi di Parma
Cognome e Nome CANTARELLA Simona
Qualifica Dottoranda
Dipartimento Scienze Chimiche, della Vita e della Sostenibilità Ambientale
Ente di appartenenza Università degli Studi di Parma

LINEE DI RICERCA

-Molecular mechanisms of eukaryotic gene transcription

-Drug discovery: identification of protein-protein interaction inhibitors

-Microbial genomics

-Functional genomics

-Molecular mycology

-Gene expression profiling and heterologous functional assays in yeast

-Genomic phenotyping in the yeast Saccharomyces cerevisiae as a tool for the functional analysis of small-molecule xenobiotics (candidate drugs and toxicants)

-Design and production of recombinant peptide immunogens (vaccines) using microbial proteins as molecular scaffolds(vaccines)

-Biomolecular approaches to Alzheimer's disease and other proteopathies: gene expression profiling, therapeutic antibodies, and heterologous functional assays in yeast


TECNOLOGIE IN POSSESSO DELL'U. O.

  • In vitro transcription

  • yeast Bioluminescence Resonance Energy Transfer (yBRET)
  • Transcriptomics and other tools for gene expression analysis
  • Genome-wide phenotyping of the yeast deletion mutant (knockout) strain collection exposed to small-molecule xenobiotics (candidate drugs and toxicants)
  • Design, construction and immunological/preclinical validation of recombinant peptide immunogens (vaccines)
  • Molecular cloning, site-directed mutagenesis
  • Immunoassays (Western blotting; immuno-dot blots; immunoprecipitation; ELISA)
  • Design, production and functional characterization of protein-scaffolded, tandemly repeated bioactive peptides; Thioredoxin Displayed Multipeptide Immunogens (TDMI)
  • Heterologous functional genomics assays in Saccharomyces cerevisiae: "signal trap", "activation trap", "nuclear trap", "yeast two-hybrid"
  • Recombinant protein expression in bacteria and yeast

STRUMENTAZIONE

Denominazione
Struttura ove la strumentazione è allocata
Responsabile della strumentazione
Phosphorimager (Bio-Rad FX)
Dip. Scienze Chimiche, della Vita e della Sostenibilità Ambientale
Dieci
Phosphorimager (Cyclone, Packard)
Dip. Scienze Chimiche, della Vita e della Sostenibilità Ambientale
Bolchi
Sistemi "multipin" per il trasferimento di collezioni ordinate (array) di cellule e macromolecole.
Dip. SScienze Chimiche, della Vita e della Sostenibilità Ambientale
Ottonello
Lettore multipiastra termostatato
Dip. Scienze Chimiche, della Vita e della Sostenibilità Ambientale
Montanini/Levati
Spettrofotometri
Dip. Scienze Chimiche, della Vita e della Sostenibilità Ambientale
Cavazzini
Varie tipologie di sistemi elettroforetici e immunoelettroforetici
Dip. Scienze Chimiche, della Vita e della Sostenibilità Ambientale
Dieci
Termostati, agitatori orbitali, fermentatori, camere di crescita e altri apparati per la crescita di cellule batteriche e fungine, e per la produzione di biomassa
Dip. Scienze Chimiche, della Vita e della Sostenibilità Ambientale
Levati
Software ‘dedicati’ per la progettazione di oligonucleotidi e proteine, per l’analisi di dati ‘microarray’ e per la catalogazione funzionale dei dati di "genomic phenotyping"
Dip. Scienze Chimiche, della Vita e della Sostenibilità Ambientale
Montanini

PUBBLICAZIONI
  1. Dieci G, Ferrari R. (2018) The third (III) road to cell transformation. Cell Cycle 2018 Feb 19:1-2
  2. Pouyanfard S, Spagnoli G, Bulli L, Balz K, Yang F, Odenwald C, Seitz H, Mariz FC, Bolchi A, Ottonello S, Müller M. (2018) Minor Capsid Protein L2 Polytope Induces Broad Protection against Oncogenic and Mucosal Human Papillomaviruses. J Virol. 2018 Jan 30;92(4). pii: e01930-17
  3. Spagnoli G, Pouyanfard S, Cavazzini D, Canali E, Maggi S, Tommasino M, Bolchi A, Müller M, Ottonello S. (2017) Broadly neutralizing antiviral responses induced by a single-molecule HPV vaccine based on thermostable thioredoxin-L2 multiepitope nanoparticles. Sci Rep. 2017 Dec 21;7(1):18000
  4. Verna AE, Franceschi V, Tebaldi G, Macchi F, Menozzi V, Pastori C, Lopalco L, Ottonello S, Cavirani S, Donofrio G. (2017) Induction of Antihuman C-C Chemokine Receptor Type 5 Antibodies by a Bovine Herpesvirus Type-4 Based Vector. Front Immunol. 2017 Oct 25;8:140
  5. Matone A, Derlindati E, Marchetti L, Spigoni V, Dei Cas A, Montanini B, Ardigò D, Zavaroni I, Priami C, Bonadonna RC. (2017) Identification of an early transcriptomic signature of insulin resistance and related diseases in lymphomonocytes of healthy subjects. PLoS One 2017 Aug 12(8):e0182559
  6. Cavazzini D, Grossi G, Levati E, Vallese F, Montanini B, Bolchi A, Zanotti G, Ottonello S. (2017) A family of archaea-like carboxylesterases preferentially expressed in the symbiotic phase of the mycorrhizal fungus Tuber melanosporum. Sci Rep. 2017 Aug 9;7(1):7628
  7. Bosio MC, Fermi B, Dieci G. (2017) Transcriptional control of yeast ribosome biogenesis: A multifaceted role for general regulatory factors. Transcription 2017 Aug 8(4):254-260
  8. Corbel C, Sartini S, Levati E, Colas P, Maillet L, Couturier C, Montanini B, Bach S. (2017) Screening for Protein-Protein Interaction Inhibitors Using a Bioluminescence Resonance Energy Transfer (BRET)-Based Assay in Yeast. SLAS Discov. 2017 Jul 22(6):751-759
  9. Bosio MC, Fermi B, Spagnoli G, Levati E, Rubbi L, Ferrari R, Pellegrini M, Dieci G.(2017) Abf1 and other general regulatory factors control ribosome biogenesis gene expression in budding yeast. Nucleic Acids Res. 2017 May 5;45(8):4493-450
  10. Gerace R, Montanini B, Proietto M, Levati E, De Luca C, Brenna A, Filetici P, Kohler A, Ottonello S, Ballario P. (2017) Photoreceptors in the dark: A functional white collar-like complex and other putative light-sensing components encoded by the genome of the subterranean fungus Tuber melanosporum. Fungal Biol. 2017 Mar;121(3):253-263

11.  Carnevali D, Conti A, Pellegrini M, Dieci G. (2017) Whole-genome expression analysis of mammalian-wide interspersed repeat elements in human cell lines. DNA Res. 2017 Feb 1;24(1):59-69

12.  Fermi B, Bosio MC, Dieci G. (2017) Multiple roles of the general regulatory factor Abf1 in yeast ribosome biogenesis. Curr Genet. 2017 Feb;63(1):65-68

13.  Spagnoli G, Bolchi A, Cavazzini D, Pouyanfard S, Müller M, Ottonello S. (2017) Secretory production of designed multipeptides displayed on a thermostable bacterial thioredoxin scaffold in Pichia pastoris. Protein Expr Purif. 2017 Jan;129:150-157

14.  Mattarozzi M, Manfredi M, Montanini B, Gosetti F, Sanangelantoni AM, Marengo E, Careri M, Visioli G. (2017) A metaproteomic approach dissecting major bacterial functions in the rhizosphere of plants living in serpentine soil. Anal Bioanal Chem. 2017 Jan 409(9):2327-2339

15.  Duranti S, Gaiani F, Mancabelli L, Milani C, Grandi A, Bolchi A, Santoni A, Lugli GA, Ferrario C, Mangifesta M, Viappiani A, Bertoni S, Vivo V, Serafini F, Barbaro MR, Fugazza A, Barbara G, Gioiosa L, Palanza P, Cantoni AM, de’Angelis GL, Barocelli E, De’Angelis N, van Sinderen D, Ventura M, Turroni F (2016). Elucidating the gut microbiome of ulcerative colitis: bifidobacteria as novel microbial biomarkers. FEMS Microbiology Ecology, 2016 Dec vol. 92 (12).

16.  Fisicaro P, Barili V, Montanini B, Acerbi G, Ferracin M, Guerrieri F, Salerno D, Boni C, Massari M, Cavallo MC, Grossi G, Giuberti T, Lampertico P, Missale G, Levrero M, Ottonello S, Ferrari C. (2017) Targeting mitochondrial dysfunction can restore antiviral activity of exhausted HBV-specific CD8 T cells in chronic hepatitis B. Nat Med. 2017 Mar;23(3):327-336

17.  Tebaldi G, Jacca S, Montanini B, Capra E, Rosamilia A, Sala A, Stella A, Castiglioni B, Ottonello S, Donofrio G. (2016) Virus-Mediated Metalloproteinase 1 Induction Revealed by Transcriptome Profiling of Bovine Herpesvirus 4-Infected Bovine Endometrial Stromal Cells. Biol Reprod. 2016 Jul;95(1):12

18.  Fermi B, Bosio MC, Dieci G. (2016) Promoter architecture and transcriptional regulation of Abf1-dependent ribosomal protein genes in Saccharomyces cerevisiae. Nucleic Acids Res. 2016 Jul 44(13):6113-26

19.  Levati E, Sartini S, Ottonello S, Montanini B. (2016) Dry and wet approaches for genome-wide functional annotation of conventional and unconventional transcriptional activators. Comput Struct Biotechnol J. 2016 Jun 29;14:262-70

20.  Conti A, Rota F, Ragni E, Favero C, Motta V, Lazzari L, Bollati V, Fustinoni S, Dieci G. (2016) Hydroquinone induces DNA hypomethylation-independent overexpression of retroelements in human leukemia and hematopoietic stem cells. Biochem Biophys Res Commun 2016 Jun 474(4):691-695

21.  Levati E, Sartini S, Bolchi A, Ottonello S, Montanini B. (2016) Moonlighting transcriptional activation function of a fungal sulfur metabolism enzyme. Sci Rep. 2016 Apr 28;6:25165

22.  Bolchi A, Canali E, Santoni A, Spagnoli G, Viarisio D, Accardi R, Tommasino M, Müller M, Ottonello S. (2015) Thioredoxin-Displayed Multipeptide Immunogens. Methods Mol Biol. 2015;1348:137-51

23.  Seitz H, Ribeiro-Müller L, Canali E, Bolchi A, Tommasino M, Ottonello S, Müller M. (2015) Robust In Vitro and In Vivo Neutralization against Multiple High-Risk HPV Types Induced by a Thermostable Thioredoxin-L2 Vaccine. Cancer Prev Res (Phila). 2015 Oct;8(10):932-41

24.  Tigano M, Ruotolo R, Dallabona C, Fontanesi F, Barrientos A, Donnini C, Ottonello S.(2015) Elongator-dependent modification of cytoplasmic tRNALysUUU is required for mitochondrial function under stress conditions. Nucleic Acids Res. 2015 Sep 30;43(17):8368-80.

25.  Jacca S, Rolih V, Quaglino E, Franceschi V, Tebaldi G, Bolli E, Rosamilia A, Ottonello S, Cavallo F, Donofrio G. (2015) Bovine herpesvirus 4-based vector delivering a hybrid rat/human HER-2 oncoantigen efficiently protects mice from autochthonous Her-2+ mammary cancer. Oncoimmunology. 2015 Aug 31;5(3):e1082705

26.  Fraccia TP, Smith GP, Zanchetta G, Paraboschi E, Yi Y, Walba DM, Dieci G, Clark NA, Bellini T. (2015) Abiotic ligation of DNA oligomers templated by their liquid crystal ordering. Nat Commun. 2015 Jun 6:6424

27.  Morselli M, Pastor WA, Montanini B, Nee K, Ferrari R, Fu K, Bonora G, Rubbi L, Clark AT, Ottonello S, Jacobsen SE, Pellegrini M. (2015) In vivo targeting of de novo DNA methylation by histone modifications in yeast and mouse. Elife. 2015 Apr 7;4:e06205.

28.  Derlindati E, Dei Cas A, Montanini B, Spigoni V, Curella V, Aldigeri R, Ardigò D, Zavaroni I, Bonadonna RC. (2015) Transcriptomic analysis of human polarized macrophages: more than one role of alternative activation? PLoS One 2015 Mar 23;10(3):e0119751

29.  Conti A, Carnevali D, Bollati V, Fustinoni S, Pellegrini M, Dieci G. (2015) Identification of RNA polymerase III-transcribed Alu loci by computational screening of RNA-Seq data. Nucleic Acids Res. 2015 Jan 43(2):817-35

30.  Ruotolo R, Calani L, Brighenti F, Crozier A, Ottonello S, Del Rio D. (2014) Glucuronidation does not suppress the estrogenic activity of quercetin in yeast and human breast cancer cell model systems. Arch Biochem Biophys. 2014 Oct 1;559:62-7

31.  Chen PY, Montanini B, Liao WW, Morselli M, Jaroszewicz A, Lopez D, Ottonello S, Pellegrini M. (2014) A comprehensive resource of genomic, epigenomic and transcriptomic sequencing data for the black truffle Tuber melanosporum. Gigascience. 2014 Oct 30;3:25.

32.  Díaz-Moreno I, Hulsker R, Skubak P, Foerster JM, Cavazzini D, Finiguerra MG, Díaz-Quintana A, Moreno-Beltrán B, Rossi GL, Ullmann GM, Pannu NS, De la Rosa MA, Ubbink M (2014). The dynamic complex of cytochrome c6 and cytochrome f studied with paramagnetic NMR spectroscopy. Biochim Biophys Acta. 2014 Aug;1837(8):1305-15

33.  Mantile F, Trovato M, Santoni A, Barba P, Ottonello S, De Berardinis P, Prisco A. (2014) Alum and squalene-oil-in-water emulsion enhance the titer and avidity of anti-Aβ antibodies induced by multimeric protein antigen (1-11)E2, preserving the Igg1-skewed isotype distribution. PLoS One. 2014 Jul 1;9(7):e101474

34.  Montanini B, Chen PY, Morselli M, Jaroszewicz A, Lopez D, Martin F, Ottonello S, Pellegrini M. (2014) Non-exhaustive DNA methylation-mediated transposon silencing in the black truffle genome, a complex fungal genome with massive repeat element content. Genome Biol. 2014 Jul 31;15(7):411.

35.  Seitz H, Canali E, Ribeiro-Müller L, Pàlfi A, Bolchi A, Tommasino M, Ottonello S, Müller M. (2014) A three component mix of thioredoxin-L2 antigens elicits broadly neutralizing responses against oncogenic human papillomaviruses. Vaccine. 2014 May 7;32(22):2610-7

36.  Brenna A, Montanini B, Muggiano E, Proietto M, Filetici P, Ottonello S, Ballario P.(2014) Integrative gene transfer in the truffle Tuber borchii by Agrobacterium tumefaciens-mediated transformation. AMB Express. 2014 May 29;4:43.

37.  Canali E, Bolchi A, Spagnoli G, Seitz H, Rubio I, Pertinhez TA, Müller M, Ottonello S. (2014) A high-performance thioredoxin-based scaffold for peptide immunogen construction: proof-of-concept testing with a human papillomavirus epitope. Sci Rep. 2014 Apr 22;4:4729

38.  Branca C, Sarnico I, Ruotolo R, Lanzillotta A, Viscomi AR, Benarese M, Porrini V, Lorenzini L, Calzà L, Imbimbo BP, Ottonello S, Pizzi M. (2014) Pharmacological targeting of the β-amyloid precursor protein intracellular domain. Sci Rep. 2014 Apr 9;4:4618

39.  Dieci G, Fermi B, Bosio MC. (2014) Investigating transcription reinitiation through in vitro approaches. Transcription. 2014 Jan 5(1):e27704

40.  Seitz H, Dantheny T, Burkart F, Ottonello S, Müller M. (2013) Influence of oxidation and multimerization on the immunogenicity of a thioredoxin-l2 prophylactic papillomavirus vaccine. Clin Vaccine Immunol. 2013 Jul;20(7):1061-9

41.  Turroni F, Serafini F, Foroni E, Duranti S, O’Connell Motherway M, Taverniti V, Mangifesta M, Milani C, Viappiani A, Roversi T, Sánchez B, Santoni A, Gioiosa L, Ferrarini A, Delledonne M, Margolles A, Piazza L, Palanza P, Bolchi A, Guglielmetti S, van Sinderen D, Ventura M (2013). The role of sortase-dependent pili of Bifidobacterium bifidum PRL2010 in modulating bacterium-host interactions. Proceedings of the national academy of sciences of the united states of america, 2013 Jul vol. 110, p. 11151-11156

42.  Penna I, Vassallo I, Nizzari M, Russo D, Costa D, Menichini P, Poggi A, Russo C, Dieci G, Florio T, Cancedda R, Pagano A. (2013) A novel snRNA-like transcript affects amyloidogenesis and cell cycle progression through perturbation of Fe65L1 (APBB2) alternative splicing. Biochim Biophys Acta. 2013 Jun 1833(6):1511-26

43.  Sivilia S, Lorenzini L, Giuliani A, Gusciglio M, Fernandez M, Baldassarro VA, Mangano C, Ferraro L, Pietrini V, Baroc MF, Viscomi AR, Ottonello S, Villetti G, Imbimbo BP, Calzà L, Giardino L. (2013) Multi-target action of the novel anti-Alzheimer compound CHF5074: in vivo study of long term treatment in Tg2576 mice. BMC Neurosci. 2013 Apr 5;14:44

44.  Dieci G, Conti A, Pagano A, Carnevali D. (2012) Identification of RNA polymerase III-transcribed genes in eukaryotic genomes. Biochim Biophys Acta. 2013 Mar-Apr 1829(3-4):296-305

45.  Dieci G, Bosio MC, Fermi B, Ferrari R. (2013) Transcription reinitiation by RNA polymerase III. Biochim Biophys Acta. 2013 Mar-Apr 1829(3-4):331-41

46.  Ciarlo E, Massone S, Penna I, Nizzari M, Gigoni A, Dieci G, Russo C, Florio T, Cancedda R, Pagano A. (2013) An intronic ncRNA-dependent regulation of SORL1 expression affecting Aβ formation is upregulated in post-mortem Alzheimer's disease brain samples. Dis Model Mech. 2013 Mar 6(2):424-33

47.  Cavazzini D, Meschi F, Corsini R, Bolchi A, Rossi GL, Einsle O, Ottonello S. (2013) Autoproteolytic Activation of a Symbiosis-regulated Truffle Phospholipase A2. J Biol Chem. 2013 Jan 18;288(3):1533-47.

48.  Ciarlo E, Massone S, Penna I, Nizzari M, Gigoni A, Dieci G, Russo C, Florio T, Cancedda R, Pagano A (2012) An intronic ncRNA-dependent regulation of SORL1 expression affecting Abeta formation is upregulated in post-mortem Alzheimer's disease brain samples. Disease models & mechanisms

49.  Imbimbo BP, Ottonello S, Frisardi V, Solfrizzi V, Greco A, Seripa D, Pilotto A, Panza F (2012) Solanezumab for the treatment of mild-to-moderate Alzheimer's disease. Expert review of clinical immunology 8: 135-149

50.  Orioli A, Pascali C, Pagano A, Teichmann M, Dieci G (2012) RNA polymerase III transcription control elements: themes and variations. Gene 493: 185-194

51.  Balducci C, Mehdawy B, Mare L, Giuliani A, Lorenzini L, Sivilia S, Giardino L, Calza L, Lanzillotta A, Sarnico I, Pizzi M, Usiello A, Viscomi AR, Ottonello S, Villetti G, Imbimbo BP, Nistico G, Forloni G, Nistico R (2011) The gamma-secretase modulator CHF5074 restores memory and hippocampal synaptic plasticity in plaque-free Tg2576 mice. J Alzheimers Dis 24: 799-816

52.  Bolchi A, Ruotolo R, Marchini G, Vurro E, di Toppi LS, Kohler A, Tisserant E, Martin F, Ottonello S (2011) Genome-wide inventory of metal homeostasis-related gene products including a functional phytochelatin synthase in the hypogeous mycorrhizal fungus Tuber melanosporum. Fungal Genet Biol 48: 573-584

53.  Bosio MC, Negri R, Dieci G (2011) Promoter architectures in the yeast ribosomal expression program. Transcription 2: 71-77

54.  Ceccaroli P, Buffalini M, Saltarelli R, Barbieri E, Polidori E, Ottonello S, Kohler A, Tisserant E, Martin F, Stocchi V (2011) Genomic profiling of carbohydrate metabolism in the ectomycorrhizal fungus Tuber melanosporum. The New phytologist 189: 751-764

55.  Donofrio G, Taddei S, Franceschi V, Capocefalo A, Cavirani S, Martinelli N, Ottonello S, Ferrari M (2011) Swine adipose stromal cells loaded with recombinant bovine herpesvirus 4 virions expressing a foreign antigen induce potent humoral immune responses in pigs. Vaccine 29: 867-872

56.  Koharudin LM, Viscomi AR, Montanini B, Kershaw MJ, Talbot NJ, Ottonello S, Gronenborn AM (2011) Structure-function analysis of a CVNH-LysM lectin expressed during plant infection by the rice blast fungus Magnaporthe oryzae. Structure 19: 662-674

57.  Massone S, Vassallo I, Castelnuovo M, Fiorino G, Gatta E, Robello M, Borghi R, Tabaton M, Russo C, Dieci G, Cancedda R, Pagano A (2011) RNA polymerase III drives alternative splicing of the potassium channel-interacting protein contributing to brain complexity and neurodegeneration. The Journal of cell biology 193: 851-866

58.  Massone S, Vassallo I, Fiorino G, Castelnuovo M, Barbieri F, Borghi R, Tabaton M, Robello M, Gatta E, Russo C, Florio T, Dieci G, Cancedda R, Pagano A (2011) 17A, a novel non-coding RNA, regulates GABA B alternative splicing and signaling in response to inflammatory stimuli and in Alzheimer disease. Neurobiology of disease 41: 308-317

59.  Montanini B, Levati E, Bolchi A, Kohler A, Morin E, Tisserant E, Martin F, Ottonello S (2011) Genome-wide search and functional identification of transcription factors in the mycorrhizal fungus Tuber melanosporum. The New phytologist 189: 736-750

60.  Orioli A, Pascali C, Quartararo J, Diebel KW, Praz V, Romascano D, Percudani R, van Dyk LF, Hernandez N, Teichmann M, Dieci G (2011) Widespread occurrence of non-canonical transcription termination by human RNA polymerase III. Nucleic acids research 39: 5499-5512

61.  Plett JM, Montanini B, Kohler A, Ottonello S, Martin F (2011) Tapping genomics to unravel ectomycorrhizal symbiosis. Methods in molecular biology (Clifton, NJ 722: 249-281

62.  Rubio I, Seitz H, Canali E, Sehr P, Bolchi A, Tommasino M, Ottonello S, Muller M (2011) The N-terminal region of the human papillomavirus L2 protein contains overlapping binding sites for neutralizing, cross-neutralizing and non-neutralizing antibodies. Virology 409: 348-359

63.  Splivallo R, Ottonello S, Mello A, Karlovsky P (2011) Truffle volatiles: from chemical ecology to aroma biosynthesis. The New phytologist 189: 688-699

64.  Turroni F, Foroni E, Montanini B, Viappiani A, Strati F, Duranti S, Ferrarini A, Delledonne M, van Sinderen D, Ventura M (2011) Global genome transcription profiling of Bifidobacterium bifidum PRL2010 under in vitro conditions and identification of reference genes for quantitative real-time PCR. Applied and environmental microbiology 77: 8578-8587

65.  Turroni F, Foroni E, Serafini F, Viappiani A, Montanini B, Bottacini F, Ferrarini A, Bacchini PL, Rota C, Delledonne M, Ottonello S, van Sinderen D, Ventura M (2011) Ability of Bifidobacterium breve To Grow on Different Types of Milk: Exploring the Metabolism of Milk through Genome Analysis. Applied and environmental microbiology 77: 7408-7417

66.  Yukawa Y, Dieci G, Alzapiedi M, Hiraga A, Hirai K, Yamamoto YY, Sugiura M (2011) A common sequence motif involved in selection of transcription start sites of Arabidopsis and budding yeast tRNA genes. Genomics 97: 166-172

67.  Castelnuovo M, Massone S, Tasso R, Fiorino G, Gatti M, Robello M, Gatta E, Berger A, Strub K, Florio T, Dieci G, Cancedda R, Pagano A (2010) An Alu-like RNA promotes cell differentiation and reduces malignancy of human neuroblastoma cells. Faseb J 24: 4033-4046

68.  Sottini S, Gast P, Blok A, Canters GW, Cavazzini D, Rossi GL, Groenen EJ (2010). A Proton ENDOR Study of Azurin. Appl Magn Reson 37(1-4) 219-227

69.  Franzoni L, Cavazzini D, Rossi GL, Lücke C (2010). New insights on the protein-ligand interaction differences between the two primary cellular retinol carriers. J Lipid Res 2010 Jun 51(6) 1332-43

70.  Martin F, Kohler A, Murat C, Balestrini R, Coutinho PM, Jaillon O, Montanini B, Morin E, Noel B, Percudani R, Porcel B, Rubini A, Amicucci A, Amselem J, Anthouard V, Arcioni S, Artiguenave F, Aury JM, Ballario P, Bolchi A, Brenna A, Brun A, Buee M, Cantarel B, Chevalier G, Couloux A, Da Silva C, Denoeud F, Duplessis S, Ghignone S, Hilselberger B, Iotti M, Marcais B, Mello A, Miranda M, Pacioni G, Quesneville H, Riccioni C, Ruotolo R, Splivallo R, Stocchi V, Tisserant E, Viscomi AR, Zambonelli A, Zampieri E, Henrissat B, Lebrun MH, Paolocci F, Bonfante P, Ottonello S, Wincker P (2010) Perigord black truffle genome uncovers evolutionary origins and mechanisms of symbiosis. Nature 464: 1033-1038

71.  Migeon A, Blaudez D, Wilkins O, Montanini B, Campbell MM, Richaud P, Thomine S, Chalot M (2010) Genome-wide analysis of plant metal transporters, with an emphasis on poplar. Cell Mol Life Sci 67: 3763-3784

72.  Nakahama T, Nakanishi Y, Viscomi AR, Takaya K, Kitamoto K, Ottonello S, Arioka M (2010) Distinct enzymatic and cellular characteristics of two secretory phospholipases A2 in the filamentous fungus Aspergillus oryzae. Fungal Genet Biol 47: 318-331

73.  Preti M, Ribeyre C, Pascali C, Bosio MC, Cortelazzi B, Rougemont J, Guarnera E, Naef F, Shore D, Dieci G (2010) The telomere-binding protein Tbf1 demarcates snoRNA gene promoters in Saccharomyces cerevisiae. Molecular cell 38: 614-620

74.  Ruotolo R, Tosi F, Vernarecci S, Ballario P, Mai A, Filetici P, Ottonello S (2010) Chemogenomic profiling of the cellular effects associated with histone H3 acetylation impairment by a quinoline-derived compound. Genomics 96: 272-280

75.  Teichmann M, Dieci G, Pascali C, Boldina G (2010) General transcription factors and subunits of RNA polymerase III: Paralogs for promoter- and cell type-specific transcription in multicellular eukaryotes. Transcription 1: 130-135

76.  Amaro F, Ruotolo R, Martin-Gonzalez A, Faccini A, Ottonello S, Gutierrez JC (2009) A pseudo-phytochelatin synthase in the ciliated protozoan Tetrahymena thermophila. Comp Biochem Physiol C Toxicol Pharmacol 149: 598-604

77.  Dieci G, Preti M, Montanini B (2009) Eukaryotic snoRNAs: a paradigm for gene expression flexibility. Genomics 94: 83-88

78.  Dieci G, Ruotolo R, Braglia P, Carles C, Carpentieri A, Amoresano A, Ottonello S (2009) Positive modulation of RNA polymerase III transcription by ribosomal proteins. Biochemical and biophysical research communications 379: 489-493

79.  Rubio I, Bolchi A, Moretto N, Canali E, Gissmann L, Tommasino M, Muller M, Ottonello S (2009) Potent anti-HPV immune responses induced by tandem repeats of the HPV16 L2 (20 -- 38) peptide displayed on bacterial thioredoxin. Vaccine 27: 1949-1956

80.  Tavenet A, Suleau A, Dubreuil G, Ferrari R, Ducrot C, Michaut M, Aude JC, Dieci G, Lefebvre O, Conesa C, Acker J (2009) Genome-wide location analysis reveals a role for Sub1 in RNA polymerase III transcription. Proceedings of the National Academy of Sciences of the United States of America 106: 14265-14270

81.  Fantuzzi A, Artali R, Bombieri G, Marchini N, Meneghetti F, Gilardi G, Sadeghi SJ, Cavazzini D, Rossi GL (2009). Redox properties and crystal structures of a Desulfovibrio vulgaris flavodoxin mutant in the monomeric and homodimeric forms. Biochim Biophys Acta 1794 496-505

82.  Ferrari R, Dieci G (2008) The transcription reinitiation properties of RNA polymerase III in the absence of transcription factors. Cellular & molecular biology letters 13: 112-118

83.  Koharudin LM, Viscomi AR, Jee JG, Ottonello S, Gronenborn AM (2008) The evolutionarily conserved family of cyanovirin-N homologs: structures and carbohydrate specificity. Structure 16: 570-584

84.  Martin F, Aerts A, Ahren D, Brun A, Danchin EG, Duchaussoy F, Gibon J, Kohler A, Lindquist E, Pereda V, Salamov A, Shapiro HJ, Wuyts J, Blaudez D, Buee M, Brokstein P, Canback B, Cohen D, Courty PE, Coutinho PM, Delaruelle C, Detter JC, Deveau A, DiFazio S, Duplessis S, Fraissinet-Tachet L, Lucic E, Frey-Klett P, Fourrey C, Feussner I, Gay G, Grimwood J, Hoegger PJ, Jain P, Kilaru S, Labbe J, Lin YC, Legue V, Le Tacon F, Marmeisse R, Melayah D, Montanini B, Muratet M, Nehls U, Niculita-Hirzel H, Oudot-Le Secq MP, Peter M, Quesneville H, Rajashekar B, Reich M, Rouhier N, Schmutz J, Yin T, Chalot M, Henrissat B, Kues U, Lucas S, Van de Peer Y, Podila GK, Polle A, Pukkila PJ, Richardson PM, Rouze P, Sanders IR, Stajich JE, Tunlid A, Tuskan G, Grigoriev IV (2008) The genome of Laccaria bicolor provides insights into mycorrhizal symbiosis. Nature 452: 88-92

85.  Ruotolo R, Marchini G, Ottonello S (2008) Membrane transporters and protein traffic networks differentially affecting metal tolerance: a genomic phenotyping study in yeast. Genome biology 9: R67

86.  Torta F, Elviri L, Careri M, Mangia A, Cavazzini D, Rossi GL (2008). Mass spectrometry and hydrogen/deuterium exchange measurements of alcohol-induced structural changes in cellular retinol-binding protein type I. Rapid Commun Mass Spectrom 22(3) 330-336

87.  Braglia P, Dugas SL, Donze D, Dieci G (2007) Requirement of Nhp6 proteins for transcription of a subset of tRNA genes and heterochromatin barrier function in Saccharomyces cerevisiae. Molecular and cellular biology 27: 1545-1557

88.  Couturier J, Montanini B, Martin F, Brun A, Blaudez D, Chalot M (2007) The expanded family of ammonium transporters in the perennial poplar plant. The New phytologist 174: 137-150

89.  Dieci G, Fiorino G, Castelnuovo M, Teichmann M, Pagano A (2007) The expanding RNA polymerase III transcriptome. Trends Genet 23: 614-622

90.  Imbimbo BP, Del Giudice E, Cenacchi V, Volta R, Villetti G, Facchinetti F, Riccardi B, Puccini P, Moretto N, Grassi F, Ottonello S, Leon A (2007) In vitro and in vivo profiling of CHF5022 and CHF5074 Two beta-amyloid1-42 lowering agents. Pharmacol Res 55: 318-328

91.  Montanini B, Blaudez D, Jeandroz S, Sanders D, Chalot M (2007) Phylogenetic and functional analysis of the Cation Diffusion Facilitator (CDF) family: improved signature and prediction of substrate specificity. BMC Genomics 8: 107

92.  Moretto N, Bolchi A, Rivetti C, Imbimbo BP, Villetti G, Pietrini V, Polonelli L, Del Signore S, Smith KM, Ferrante RJ, Ottonello S (2007) Conformation-sensitive antibodies against alzheimer amyloid-beta by immunization with a thioredoxin-constrained B-cell epitope peptide. The Journal of biological chemistry 282: 11436-11445

93.  Pagano A, Castelnuovo M, Tortelli F, Ferrari R, Dieci G, Cancedda R (2007) New small nuclear RNA gene-like transcriptional units as sources of regulatory transcripts. PLoS genetics 3: e1

94.  Peiter E, Montanini B, Gobert A, Pedas P, Husted S, Maathuis FJ, Blaudez D, Chalot M, Sanders D (2007) A secretory pathway-localized cation diffusion facilitator confers plant manganese tolerance. Proceedings of the National Academy of Sciences of the United States of America 104: 8532-8537

95.  de Jongh TE, Hoffmann M , Einsle O , Cavazzini D , Rossi GL , Ubbink M , Canters GW (2007). Inter- and intramolecular electron transfer in modified azurin dimers. Eur. J. Inorg. Chem. 18 2627-2634

96.  Dieci G, Yukawa Y, Alzapiedi M, Guffanti E, Ferrari R, Sugiura M, Ottonello S (2006) Distinct modes of TATA box utilization by the RNA polymerase III transcription machineries from budding yeast and higher plants. Gene 379: 12-25

97.  Donini S, Percudani R, Credali A, Montanini B, Sartori A, Peracchi A (2006) A threonine synthase homolog from a mammalian genome. Biochemical and biophysical research communications 350: 922-928

98.  Grassi F, Moretto N, Rivetti C, Cellai S, Betti M, Marquez AJ, Maraini G, Ottonello S (2006) Structural and functional properties of lengsin, a pseudo-glutamine synthetase in the transparent human lens. Biochemical and biophysical research communications 350: 424-429

99.  Guffanti E, Ferrari R, Preti M, Forloni M, Harismendy O, Lefebvre O, Dieci G (2006) A minimal promoter for TFIIIC-dependent in vitro transcription of snoRNA and tRNA genes by RNA polymerase III. The Journal of biological chemistry 281: 23945-23957

100. Guffanti E, Percudani R, Harismendy O, Soutourina J, Werner M, Iacovella MG, Negri R,  Dieci G (2006) Nucleosome depletion activates poised RNA polymerase III at unconventional transcription sites in Saccharomyces cerevisiae. The Journal of biological chemistry 281: 29155-29164

101. Montanini B, Gabella S, Abba S, Peter M, Kohler A, Bonfante P, Chalot M, Martin F, Ottonello S (2006) Gene expression profiling of the nitrogen starvation stress response in the mycorrhizal ascomycete Tuber borchii. Fungal Genet Biol 43: 630-641

102. Montanini B, Viscomi AR, Bolchi A, Martin Y, Siverio JM, Balestrini R, Bonfante P, Ottonello S (2006) Functional properties and differential mode of regulation of the nitrate transporter from a plant symbiotic ascomycete. The Biochemical journal 394: 125-134

103. Preti M, Guffanti E, Valitutto E, Dieci G (2006) Assembly into snoRNP controls 5'-end maturation of a box C/D snoRNA in Saccharomyces cerevisiae. Biochemical and biophysical research communications 351: 468-473

104. Tuskan GA, Difazio S, Jansson S, Bohlmann J, Grigoriev I, Hellsten U, Putnam N, Ralph S, Rombauts S, Salamov A, Schein J, Sterck L, Aerts A, Bhalerao RR, Bhalerao RP, Blaudez D, Boerjan W, Brun A, Brunner A, Busov V, Campbell M, Carlson J, Chalot M, Chapman J, Chen GL, Cooper D, Coutinho PM, Couturier J, Covert S, Cronk Q, Cunningham R, Davis J, Degroeve S, Dejardin A, Depamphilis C, Detter J, Dirks B, Dubchak I, Duplessis S, Ehlting J, Ellis B, Gendler K, Goodstein D, Gribskov M, Grimwood J, Groover A, Gunter L, Hamberger B, Heinze B, Helariutta Y, Henrissat B, Holligan D, Holt R, Huang W, Islam-Faridi N, Jones S, Jones-Rhoades M, Jorgensen R, Joshi C, Kangasjarvi J, Karlsson J, Kelleher C, Kirkpatrick R, Kirst M, Kohler A, Kalluri U, Larimer F, Leebens-Mack J, Leple JC, Locascio P, Lou Y, Lucas S, Martin F, Montanini B, Napoli C, Nelson DR, Nelson C, Nieminen K, Nilsson O, Pereda V, Peter G, Philippe R, Pilate G, Poliakov A, Razumovskaya J, Richardson P, Rinaldi C, Ritland K, Rouze P, Ryaboy D, Schmutz J, Schrader J, Segerman B, Shin H, Siddiqui A, Sterky F, Terry A, Tsai CJ, Uberbacher E, Unneberg P, Vahala J, Wall K, Wessler S, Yang G, Yin T, Douglas C, Marra M, Sandberg G, Van de Peer Y, Rokhsar D (2006) The genome of black cottonwood, Populus trichocarpa (Torr. & Gray). Science 313: 1596-1604

105. Careri M, Elviri L, Mangia A, Zagnoni I, Torta F, Cavazzini D, Rossi G L (2006). Mass spectrometry techniques for detection of ligand-dependent changes in the conformational flexibility of cellular retinol-binding protein type I localized by hydrogen/deuterium exchange. Rapid Commun. Mass Spectrom. 20(13) 1973-1980.

106. Fittipaldi M, Warmerdam GC, de Waal EC, Canters GW, Cavazzini D, Rossi GL, Huber M, Groenen EJ (2006). Spin-Density Distribution in the Copper Site of Azurin. Chemphyschem 7(6) 1286-1293.

107. Mittag T , Franzoni L , Cavazzini D , Schaffhausen B , Rossi GL , Gunther UL (2006). Retinol modulates site-specific mobility of apo-cellular retinol-binding protein to promote ligand binding. J. Am. Chem. Soc. 128(30) 9844-9848

108. Bolchi A, Ottonello S, Petrucco S (2005) A general one-step method for the cloning of PCR products. Biotechnology and applied biochemistry 42: 205-209

109. Braglia P, Percudani R, Dieci G (2005) Sequence context effects on oligo(dT) termination signal recognition by Saccharomyces cerevisiae RNA polymerase III. The Journal of biological chemistry 280: 19551-19562

110. Conesa C, Ruotolo R, Soularue P, Simms TA, Donze D, Sentenac A, Dieci G (2005) Modulation of yeast genome expression in response to defective RNA polymerase III-dependent transcription. Molecular and cellular biology 25: 8631-8642

111. Dieci G, Bottarelli L, Ottonello S (2005) A general procedure for the production of antibody reagents against eukaryotic ribosomal proteins. Protein and peptide letters 12: 555-560

112. Gabella S, Abba S, Duplessis S, Montanini B, Martin F, Bonfante P (2005) Transcript profiling reveals novel marker genes involved in fruiting body formation in Tuber borchii. Eukaryot Cell 4: 1599-1602

113. Grimaldi B, de Raaf MA, Filetici P, Ottonello S, Ballario P (2005) Agrobacterium-mediated gene transfer and enhanced green fluorescent protein visualization in the mycorrhizal ascomycete Tuber borchii: a first step towards truffle genetics. Current genetics 48: 69-74

114. Ikeno Y, Konno N, Cheon SH, Bolchi A, Ottonello S, Kitamoto K, Arioka M (2005) Secretory phospholipases A2 induce neurite outgrowth in PC12 cells through lysophosphatidylcholine generation and activation of G2A receptor. The Journal of biological chemistry 280: 28044-28052

115. Miozzi L, Balestrini R, Bolchi A, Novero M, Ottonello S, Bonfante P (2005) Phospholipase A2 up-regulation during mycorrhiza formation in Tuber borchii. The New phytologist 167: 229-238

116. Percudani R, Montanini B, Ottonello S (2005) The anti-HIV cyanovirin-N domain is evolutionarily conserved and occurs as a protein module in eukaryotes. Proteins 60: 670-678

117. Alagaratnam S, van Pouderoyen G, Pijning T, Dijkstra BW, Cavazzini D, Rossi GL, van Dongen WM, van Mierlo CP, van Berkel WJ, Canters GW (2005). A crystallographic study of Cys69Ala flavodoxin II from Azotobacter vinelandii: Structural determinants of redox potential. Protein Sci 14(9) 2284-95.

118. Mittag T, Franzoni L, Cavazzini D, Rossi GL, Günther UL (2005). Novel insights into the mechanism of retinol binding by cellular retinol-binding protein. In "Structure, Dynamics and Function of Biological Macromolecules and Assemblies" (Puglisi J.D. Ed.), NATO Science Series: Life and Behavioural Sciences, IOS Press, Amsterdam. 364 109-122

119. Artali R, Marchini M, Meneghetti F, Cavazzini D, Cassetta A, Sassone C (2005). Structure of S35C Flavodoxin mutant from Desulfovibrio vulgaris in the semiquinone state. Acta Crystallogr. D Biol. Crystallogr. D61 481-484.

120. Ferrari R, Rivetti C, Acker J, Dieci G (2004) Distinct roles of transcription factors TFIIIB and TFIIIC in RNA polymerase III transcription reinitiation. Proceedings of the National Academy of Sciences of the United States of America 101: 13442-13447

121. Ferrari R, Rivetti C, Dieci G (2004) Transcription reinitiation properties of bacteriophage T7 RNA polymerase. Biochemical and biophysical research communications 315: 376-380

122. Guffanti E, Corradini R, Ottonello S, Dieci G (2004) Functional dissection of RNA polymerase III termination using a peptide nucleic acid as a transcriptional roadblock. The Journal of biological chemistry 279: 20708-20716

123. Ruotolo R, Peracchi A, Bolchi A, Infusini G, Amoresano A, Ottonello S (2004) Domain organization of phytochelatin synthase: functional properties of truncated enzyme species identified by limited proteolysis. The Journal of biological chemistry 279: 14686-14693

124. Careri M, Elviri L, Zagnoni I, Cavazzini D, Rossi GL (2004). Complexes between recombinant intracellular carriers of vitamin A and their specific ligands investigated by electrospray-mass spectrometry. Eur J Mass Spectrom (Chichester, Eng) 10(3) 429-436

125. Torta F, Dyuysekina AE, Cavazzini D, Fantuzzi A, Bychkova VE, Rossi GL (2004). Solvent-induced ligand dissociation and conformational states of Cellular Retinol-Binding Protein Type I. Biochim. Biophys. Acta 1703(1) 21-29

126. Cavazzini D, Catizone A, Galdieri M, Ottonello S (2003) Vitamin A metabolism in cultured somatic cells from rat testis. Molecular and cellular biochemistry 252: 165-171

127. Dieci G, Sentenac A (2003) Detours and shortcuts to transcription reinitiation. Trends in biochemical sciences 28: 202-209

128. Giuliodori S, Percudani R, Braglia P, Ferrari R, Guffanti E, Ottonello S, Dieci G (2003) A composite upstream sequence motif potentiates tRNA gene transcription in yeast. Journal of molecular biology 333: 1-20

129. Montanini B, Betti M, Marquez AJ, Balestrini R, Bonfante P, Ottonello S (2003) Distinctive properties and expression profiles of glutamine synthetase from a plant symbiotic fungus. The Biochemical journal 373: 357-368

130. Nakashima S, Ikeno Y, Yokoyama T, Kuwana M, Bolchi A, Ottonello S, Kitamoto K, Arioka M (2003) Secretory phospholipases A2 induce neurite outgrowth in PC12 cells. The Biochemical journal 376: 655-666

131. Rivetti C, Codeluppi S, Dieci G, Bustamante C (2003) Visualizing RNA extrusion and DNA wrapping in transcription elongation complexes of bacterial and eukaryotic RNA polymerases. Journal of molecular biology 326: 1413-1426

132. Ruotolo R, Grassi F, Percudani R, Rivetti C, Martorana D, Maraini G, Ottonello S (2003) Gene expression profiling in human age-related nuclear cataract. Molecular vision 9: 538-548

133. Careri M, Elviri L, Zagnoni I, Cavazzini D, Rossi GL (2003). Acid-induced denaturation of cellular retinol-binding

134.  proteins types I and II studied by electrospray mass spectrometry. Rapid Commun. Mass Spectrom 17(24) 2773-2780.

135. Dieci G, Giuliodori S, Catellani M, Percudani R, Ottonello S (2002) Intragenic promoter adaptation and facilitated RNA polymerase III recycling in the transcription of SCR1, the 7SL RNA gene of Saccharomyces cerevisiae. The Journal of biological chemistry 277: 6903-6914

136. Lanfranco L, Bolchi A, Ros EC, Ottonello S, Bonfante P (2002) Differential expression of a metallothionein gene during the presymbiotic versus the symbiotic phase of an arbuscular mycorrhizal fungus. Plant physiology 130: 58-67

137. Montanini B, Moretto N, Soragni E, Percudani R, Ottonello S (2002) A high-affinity ammonium transporter from the mycorrhizal ascomycete Tuber borchii. Fungal Genet Biol 36: 22-34

138. Petrucco S, Volpi G, Bolchi A, Rivetti C, Ottonello S (2002) A nick-sensing DNA 3'-repair enzyme from Arabidopsis. The Journal of biological chemistry 277: 23675-23683

139. Artali R, Bombieri G, Meneghetti F, Gilardi G, Sadeghi SJ, Cavazzini D, Rossi GL (2002). Comparison of the refined crystal structures of wild-type (1.34 Å) flavodoxin from Desulfovibrio vulgaris and the S35C mutant (1.44 Å) at 100 K. Acta Crystallogr. Sect. D-Biol. Crystallogr.

140. Franzoni L, Lücke C, Pérez C, Cavazzini D, Rademacher M, Ludwig C, Spisni A, Rossi GL, Rüterjans H (2002). Structure and Backbone Dynamics of Apo- and Holo-Cellular Retinol-Binding Protein in Solution. J. Biol. Chem. 277(24) 21983-21997.

141. Van Amsterdam IMC, Ubbink M, Einsle O, Messerschmidt A, Merli A, Cavazzini D, Rossi GL, Canters GW (2002). Dramatic modulation of electron transfer in protein complexes by crosslinking. Nat. Struct. Biol. 9(1) 48-52.

142. Betti M, Petrucco S, Bolchi A, Dieci G, Ottonello S (2001) A plant 3'-phosphoesterase involved in the repair of DNA strand breaks generated by oxidative damage. The Journal of biological chemistry 276: 18038-18045

143. Chiapponi C, Carta A, Petrucco S, Maraini G, Ottonello S (2001) Transcriptional up-regulation of the protooncogenes c-fos and c-jun following vitreous removal and short-term in vitro culture of bovine lenses. Experimental eye research 72: 565-571

144. Dieci G, Corradini R, Sforza S, Marchelli R, Ottonello S (2001) Inhibition of RNA polymerase III elongation by a T10 peptide nucleic acid. The Journal of biological chemistry 276: 5720-5725

145. Folli C, Calderone V, Ottonello S, Bolchi A, Zanotti G, Stoppini M, Berni R (2001) Identification, retinoid binding, and x-ray analysis of a human retinol-binding protein. Proceedings of the National Academy of Sciences of the United States of America 98: 3710-3715

146. Soragni E, Bolchi A, Balestrini R, Gambaretto C, Percudani R, Bonfante P, Ottonello S (2001) A nutrient-regulated, dual localization phospholipase A(2) in the symbiotic fungus Tuber borchii. The EMBO journal 20: 5079-5090

147. Elviri L, Zagnoni I, Careri M, Cavazzini D, Rossi GL (2001). Non-covalent binding of endogenous ligands to recombinant cellular retinol-binding proteins studied by mass spectrometric techniques. Rapid Commun. Mass Spectrom. 15(22) 2186-2192.

148. Balestrini R, Mainieri D, Soragni E, Garnero L, Rollino S, Viotti A, Ottonello S, Bonfante P (2000) Differential expression of chitin synthase III and IV mRNAs in ascomata of Tuber borchii Vittad. Fungal Genet Biol 31: 219-232

149. Dieci G, Bottarelli L, Ballabeni A, Ottonello S (2000) tRNA-assisted overproduction of eukaryotic ribosomal proteins. Protein expression and purification 18: 346-354

150. Dieci G, Percudani R, Giuliodori S, Bottarelli L, Ottonello S (2000) TFIIIC-independent in vitro transcription of yeast tRNA genes. Journal of molecular biology 299: 601-613

151. Ottonello S, Foroni C, Carta A, Petrucco S, Maraini G (2000) Oxidative stress and age-related cataract. Ophthalmologica-International Jour



DOTTORATI DI RICERCA

Componente U.O. Dottorato di Ricerca Coordinatore Sede
prof. Simone Ottonello
Biotecnologie e Bioscienze
prof. Simone Ottonello
Parma
prof. Angelo Bolchi
Biotecnologie e Bioscienze
prof. Simone Ottonello
Parma
prof. Giorgio Dieci
Biotecnologie e Bioscienze
prof. Simone Ottonello
Parma
prof. Barbara Montanini
Biotecnologie e Bioscienze
prof. Simone Ottonello
Parma

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