|
|
|
|
|
RESPONSABILE DELLA U. O. |
|
|
|
|
|
|
Cognome e Nome |
Ragg Enzio M.
|
|
|
Qualifica |
Prof. Straordinario
|
|
|
Facoltà |
Agraria – Università degli Studi –Milano |
|
|
Dipartimento |
Scienze Molecolari Agroalimentari |
|
|
Settore Scientifico Disciplinare |
CHIM/06 (Chimica Organica) |
|
|
E-mail |
Questo indirizzo e-mail è protetto dallo spam bot. Abilita Javascript per vederlo.
|
|
|
|
|
|
PERSONALE STRUTTURATO |
|
|
|
|
|
|
|
Cognome e Nome |
Ragg Enzio M. |
|
|
Qualifica |
PO
|
|
|
Dipartimento |
Scienze Molecolari Agroalimentari
|
|
|
Ente di appartenenza |
Università degli Studi - Milano
|
|
|
 |
|
|
|
Cognome e Nome |
Bellucci Maria Cristina |
|
|
Qualifica |
RU |
|
|
Dipartimento |
Scienze Molecolari Agroalimentari
|
|
|
Ente di appartenenza |
Università degli Studi - Milano
|
|
|
|
|
|
|
Cognome e Nome |
Mazzini Stefania
|
|
|
Qualifica |
RU
|
|
|
Dipartimento |
Scienze Molecolari Agroalimentari
|
|
|
Ente di appartenenza |
Università degli Studi - Milano
|
|
|
|
|
|
|
Cognome e Nome |
Mondelli Rosanna |
|
|
Qualifica |
PO |
|
|
Dipartimento |
Scienze Molecolari Agroalimentari
|
|
|
Ente di appartenenza |
Università degli Studi - Milano
|
|
|
|
|
|
|
Cognome e Nome |
Scaglioni Leonardo |
|
|
Qualifica |
RU
|
|
|
Dipartimento |
Scienze Molecolari Agroalimentari
|
|
|
Ente di appartenenza |
Università degli Studi - Milano
|
|
|
|
|
|
|
Cognome e Nome |
|
|
|
Qualifica |
|
|
|
Dipartimento |
|
|
|
Ente di appartenenza |
|
|
|
|
|
|
PERSONALE NON STRUTTURATO |
|
|
|
|
|
|
Cognome e Nome |
Galbusera Valerio
|
|
|
Qualifica |
Dottorando |
|
|
Dipartimento |
Scienze Molecolari Agroalimentari
|
|
|
Ente di appartenenza |
Università degli Studi - Milano
|
|
|
|
|
|
|
Cognome e Nome |
|
|
|
Qualifica |
|
|
|
Dipartimento |
|
|
|
Ente di appartenenza |
|
|
|
|
|
|
|
Cognome e Nome |
|
|
|
Qualifica |
|
|
|
Dipartimento |
|
|
|
Ente di appartenenza |
|
|
|
|
|
|
|
Cognome e Nome |
|
|
|
Qualifica |
|
|
|
Dipartimento |
|
|
|
Ente di appartenenza |
|
|
|
|
|
|
|
Cognome e Nome |
|
|
|
Qualifica |
|
|
|
Dipartimento |
|
|
|
Ente di appartenenza |
|
|
|
|
|
|
|
Cognome e Nome |
|
|
|
Qualifica |
|
|
|
Dipartimento |
|
|
|
Ente di appartenenza |
|
|
|
|
|
|
LINEE DI RICERCA |
|
|
|
|
|
|
|
1. Structure and Dynamics of Biopolymers by NMR spectroscopy and computational chemistry. Research aims: development of spectroscopic and computational methodologies for the study of complex biological systems. Our group deals with the quantitative measurement of geometrical (torsion angles and interatomic distances) and dynamical parameters (overall and internal correlation times), to be utilised as restraints in molecular dynamics simulations of solvated systems. The three-dimensional structure and the intrinsic mobility of macromolecules in solution are actually two important features for a deep understanding of molecular recognition mechanisms.
2. Studies on DNA-xenobiotic Molecular Recognition for the design of new antitumour agents. Research topics: QSAR studies on novel topoisomerase inhibitors. Photodynamic activity of perylenequinones. Studies on the interaction between oligonucleotide and N-heterocyclic systems. Structural analysis of ligand-DNA complexes, together with association constants and mean residence time measurements.
3. Conformational Analysis of natural and synthetic peptides with potential antitumoural activity. Research topics: Structure-function relationship studies on serine protease inhibitors from leguminous plants. Anti-angiogenic peptides.
4. Isolation and Structural Characterisation of biologically active secondary metabolites. Research aims: novel natural substances endowed with antifeedant and insecticide activity extracted from forage plants. Many plants produce a wide variety of secondary metabolites with toxic, repellent or antifeedant activity towards phytophagous insects, which may be utilised with success in agriculture. Our research aims at the screening of selected secondary metabolites (“metabolic profiling”) by their structural elucidation and measurement of their efficacy againts agriculturally relevant insect species.
|
|
|
|
|
|
TECNOLOGIE IN POSSESSO DELL'U. O. |
|
|
|
|
|
|
- High-field homo- and hetero-nuclear NMR Spectroscopy in solution and solid state
- Microimaging System MRI (from Aprile 2006)
- Computing workstations for molecular dynamics simulation of solvated proteins and nucleic acids
|
|
|
|
|
|
STRUMENTAZIONE |
|
|
|
|
|
|
|
|
Denominazione
|
Struttura ove la strumentazione è allocata
|
Responsabile della strumentazione
|
|
NMR Spectrometer Bruker Avance 600
|
DISMA
|
E.M. Ragg
|
|
NMR Spectrometer Bruker AMX 300
|
DISMA
|
L. Scaglioni
|
|
Workstation Silicon Graphics IRIS35
|
DISMA
|
L. Scaglioni
|
|
NMR Microprobe 1mm 1H/13C/15N
|
DISMA
|
E.M. Ragg
|
|
Microimaging (MRI) accessory 600MHz 5-10 mm
|
DISMA
|
E.M. Ragg
|
|
|
|
|
|
|
PUBBLICAZIONI |
|
|
|
|
|
|
|
1. Mele A, Romano G, Giannone M, Ragg E, Fronza G, Raos G, Marcon V. The Local Structure of Ionic Liquids: Cation-Cation NOE Interactions and Internuclear Distances in Neat [BMIM][BF(4)] and [BDMIM][BF(4)]. Angew Chem Int Ed Engl. 2006 Jan 13 (ed. on-line)
2. Arnone, A.; Bava, A.; Fronza, G.; Nasini, G.; Ragg, E. Concavine, an unusual diterpenic alkaloid produced by the fungus Clitocybe concava Tetrahedron Letters 46(46) 2005
3. Koepler O, Mazzini S, Bellucci MC, Mondelli R, Baro A, Laschat S, Hotfilder M, Viseur C, Frey W. : Synthesis and DNA binding properties of novel benzo[b]isoquino[2,3-h]-naphthyridines. Org Biomol Chem. 2005;3(15):2848-58.
4. Mazzini S, Scaglioni L, Mondelli R, Rocchi R, Biondi L, Gobbo M. . Conformational study on glycosylated asparagine-oligopeptides by NMR spectroscopy and molecular dynamics calculations. J Pept Sci. 2005; 11(8):452-62.
5. Mazzini S, Bellucci MC, Dallavalle S, Fraternali F, Mondelli R. Mode of binding of camptothecins to double helix oligonucleotides. Org Biomol Chem. 2004; 2(4):505-13.
6. Volonterio A. Bellosta S. Bravin F. Bellucci MC. Bruche L. Colombo G. Malpezzi L. Mazzini S. Meille SV. Meli M. Ramirez De Arellano C. Zanda M. Synthesis, structure and conformation of partially-modified retro- and retro-inverso psi[NHCH(CF3)]Gly peptides. Chemistry-A European Journal. 2003; 9(18):4510-22,
7. Mazzini S, Bellucci MC, Mondelli R. Mode of binding of the cytotoxic alkaloid berberine with the double helix oligonucleotide d(AAGAATTCTT)(2). Bioorg Med Chem. 2003;11(4):505-14.
8. Chillemi F. Francescato P. Ragg E. Cattaneo MG. Pola S. Vicentini L. Studies on the structure-activity relationship of endostatin: synthesis of human endostatin peptides exhibiting potent antiangiogenic activities. Journal of Medicinal Chemistry. 2003; 46(19):4165-72
9. Geroni C. Marchini S. Cozzi P. Galliera E. Ragg E. Colombo T. Battaglia R. Howard M. D'Incalci M. Broggini M. Brostallicin, a novel anticancer agent whose activity is enhanced upon binding to glutathione. Cancer Research. 2002; 62(8):2332-6
10. Tagliavini F, Forloni G, Colombo L, Rossi G, Girola L, Canciani B, Angeretti N, Giampaolo L, Peressini E, Awan T, De Gioia L, Ragg E, Bugiani O, Salmona M. Tetracycline affects abnormal properties of synthetic PrP peptides and PrP(Sc) in vitro. J Mol Biol. 2000;300(5):1309-22.
|
|
|
|
|
|
DOTTORATI DI RICERCA |
|
|
|
|
|
|
|
| Componente U.O. |
Dottorato di Ricerca |
Coordinatore |
Sede |
|
E.M. Ragg
|
Biotecnologie degli Alimenti
|
Luciano Piergiovanni
|
Milano
|
|
|
|
|
|
|
|
|
|
|
CONGRESSI C.I.B. |
|
|
|
|
|
|
|
| Congressi |
Partecipazione |
|
CNB4
|
|
|
CNB5
|
|
|
CNB6
|
|
|
CNB7
|
|
|
CNB8
|
|
| CNB9 |
|
| CNB10 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Consorzio (sedi e unità operative) 
Polesine Web Design