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RESPONSABILE DELLA U. O. |
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Cognome e Nome |
Raugei Giovanni |
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Qualifica |
Full Professor (P.O.) |
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Facoltà |
Medicine |
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Dipartimento |
Department of Biochemical Sciences |
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Settore Scientifico Disciplinare |
BIO/11 |
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E-mail |
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PERSONALE STRUTTURATO |
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Cognome e Nome |
CAMICI GUIDO |
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Qualifica |
FULL PROFESSOR
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Dipartimento |
Biochemical Sciences |
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Ente di appartenenza |
University of Florence, Italy |
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Cognome e Nome |
CAPPUGI GIANNI |
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Qualifica |
FULL PROFESSOR |
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Dipartimento |
Biochemical Sciences |
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Ente di appartenenza |
University of Florence, Italy |
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Cognome e Nome |
CASELLI ANNA
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Qualifica |
RESEARCHER |
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Dipartimento |
Biochemical Sciences |
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Ente di appartenenza |
University of Florence, Italy |
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Cognome e Nome |
CHIARUGI PAOLA
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Qualifica |
FULL PROFESSOR
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Dipartimento |
Biochemical Sciences |
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Ente di appartenenza |
University of Florence, Italy |
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Cognome e Nome |
CHITI FABRIZIO |
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Qualifica |
ASSOCIATED PROFESSOR
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Dipartimento |
Biochemical Sciences |
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Ente di appartenenza |
University of Florence, Italy |
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Cognome e Nome |
CIRRI PAOLO
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Qualifica |
ASSOCIATED PROFESSOR
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Dipartimento |
Biochemical Sciences |
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Ente di appartenenza |
University of Florence, Italy |
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Cognome e Nome |
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Qualifica |
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Dipartimento |
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Ente di appartenenza |
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Cognome e Nome |
GIANNONI ELISA
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Qualifica |
ASSOCIATED PROFESSOR
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Dipartimento |
Biochemical Sciences |
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Ente di appartenenza |
University of Florence, Italy |
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Cognome e Nome |
MANAO GIAMPAOLO
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Qualifica |
FULL PROFESSOR
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Dipartimento |
Biochemical Sciences |
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Ente di appartenenza |
University of Florence, Italy |
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Cognome e Nome |
MARZOCCHINI RICCARDO |
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Qualifica |
RESEARCHER
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Dipartimento |
Biochemical Sciences |
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Ente di appartenenza |
University of Florence, Italy |
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Cognome e Nome |
NASSI PAOLO ANTONIO |
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Qualifica |
FULL PROFESSOR
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Dipartimento |
Biochemical Sciences |
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Ente di appartenenza |
University of Florence, Italy |
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Cognome e Nome |
PAOLA BRUNI |
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Qualifica |
FULL PROFESSOR
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Dipartimento |
Biochemical Sciences |
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Ente di appartenenza |
University of Florence, Italy |
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Cognome e Nome |
PAOLI PAOLO |
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Qualifica |
RESEARCHER
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Dipartimento |
Biochemical Sciences |
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Ente di appartenenza |
University of Florence, Italy |
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Cognome e Nome |
PAZZAGLI LUIGIA
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Qualifica |
ASSOCIATED PROFESSOR |
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Dipartimento |
Biochemical Sciences |
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Ente di appartenenza |
University of Florence, Italy |
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Cognome e Nome |
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Qualifica |
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Dipartimento |
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Ente di appartenenza |
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Cognome e Nome |
RAUGEI GIOVANNI |
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Qualifica |
FULL PROFESSOR |
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Dipartimento |
Biochemical Sciences |
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Ente di appartenenza |
University of Florence, Italy |
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Cognome e Nome |
TADDEI MARIA LETIZIA |
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Qualifica |
RESEARCHER
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Dipartimento |
Biochemical Sciences |
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Ente di appartenenza |
University of Florence, Italy |
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Cognome e Nome |
TADDEI NICCOLO’
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Qualifica |
FULL PROFESSOR
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Dipartimento |
Biochemical Sciences |
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Ente di appartenenza |
University of Florence, Italy |
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Cognome e Nome |
TREVES CRISTINA
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Qualifica |
FULL PROFESSOR
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Dipartimento |
Biochemical Sciences |
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Ente di appartenenza |
University of Florence, Italy |
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Cognome e Nome |
VINCENZINI MARIA TERESA
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Qualifica |
FULL PROFESSOR |
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Dipartimento |
Biochemical Sciences |
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Ente di appartenenza |
University of Florence, Italy |
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PERSONALE NON STRUTTURATO |
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Cognome e Nome |
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Dipartimento |
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Cognome e Nome |
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Qualifica |
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Dipartimento |
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Ente di appartenenza |
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Cognome e Nome |
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LINEE DI RICERCA |
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Antibodies: this topic deals with a study on the immunoreactivity of the major allergens purified from Polistes gallicus venom.
Enzymology: this topic deals with studies on the structure-function relationships in the phosphomonohydrolase superfamily enzymes. The final goal is to produce high affinity selective inhibitors.
Molecular basis of diseases: this topic deals with: i) the ephrin signal transduction pathways and function in normal and oncogenic development; ii) the role of reactive oxygen species in cancer progression and invasion; iii) the role of the poly-(ADP-ribose) polymerase and of redox sensitive protein kinases in the heart damage that follows post-ischemic reperfusion injury; iv) the role of proteins secreted by phytotoxic fungi in plant diseases.
Protein folding and misfolding: this topic deals with the study of the molecular basis of protein folding, misfolding and aggregation as well as to the structure of amyloid.
Proteomics: the proteomic technology is applied to study the complex signal proteins that involves phosphorylation as well as reversible-oxidation.
Signal transduction: This topic deals with: i) the reactive oxygen species as intracellular messengers and as stress agents; ii) the molecular mechanisms governing cell migration and proliferation in normal and cancer cells; iii) the study of the biological activity and molecular mechanism of action of sphingosine 1-phosphate in skeletal muscle and staminal cells; iv) the study of the role of lipid rafts in the regulation of sphingosine 1-phosphate metabolism and its evoked response. An additional research deals with the study of the molecular action of the 1,25-dihydroxyvitamin D3 and D3-derivatives with low calcemic activity in cultured cells. |
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TECNOLOGIE IN POSSESSO DELL'U. O. |
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- Recombinant DNA technologies
- Amino acid analysis and protein sequencing technologies
- Immuno-based technologies
- Technologies for protein folding analysis
- Technologies for proteome analysis
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STRUMENTAZIONE |
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Denominazione
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Struttura ove la strumentazione è allocata
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Responsabile della strumentazione
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MALDI-TOF MASS SPECTROMETER
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Department of Biochemical Sciences, University of Florence
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Dott. Anna Caselli
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Amino acid analyzer
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Department of Biochemical Sciences, University of Florence
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Prof. Luigia Pazzagli
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Protein sequencer
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Department of Biochemical Sciences, University of Florence
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Prof. Giampaolo Manao
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Stopped-flow instrument
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Department of Biochemical Sciences, University of Florence
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Prof. Fabrizio Chiti
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Laser light-scattering
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Department of Biochemical Sciences, University of Florence
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Prof. Fabrizio Chiti
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Circular dichroism spectrometer
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Department of Biochemical Sciences, University of Florence
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Prof. Niccolò Taddei
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FT-IR spectrometer
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Department of Biochemical Sciences, University of Florence
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Prof. Niccolò Taddei
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Ultracentrifuge
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Department of Biochemical Sciences, University of Florence
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Dott. Riccardo Marzocchini
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Preparative centrifuges
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Department of Biochemical Sciences, University of Florence
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Dott. Riccardo Marzocchini
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Liquid scintillation counter
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Department of Biochemical Sciences, University of Florence
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Prof. Giovanni Raugei
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HPLC instruments
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Department of Biochemical Sciences, University of Florence
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Prof. Luigia Pazzagli
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PUBBLICAZIONI |
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1. Stio M, Celli A, Treves C. Synergistic anti-proliferative effects of vitamin D derivatives and 9-cis retinoic acid in SH-SY5Y human neuroblastoma cells. J Steroid Biochem Mol Biol. 2001 Jun; 77(4-5):213-22.
2 Chiti F, Stefani M, Taddei N, Ramponi G, Dobson CM. Rationalization of the effects of mutations on peptide and protein aggregation rates. Nature. 2003 Aug 14;424(6950):805-8.
3. Paoli P, Pazzagli L, Giannoni E, Caselli A, Manao G, Camici G, Ramponi G. A nucleophilic catalysis step is involved in the hydrolysis of aryl phosphate monoesters by human CT acylphosphatase. J Biol Chem. 2003 Jan 3;278(1):194-9. Epub 2002 Oct 29
4. Chiarugi P, Cirri P. Redox regulation of protein tyrosine phosphatases during receptor tyrosine kinase signal transduction. Trends Biochem Sci. 2003 Sep;28(9):509-14. Review.
5. Pantera B, Hoffman DR, Carresi L, Cappugi G, Turillazzi S, Manao G, Severino M, Spadolini I, Orsomando G, Moneti G, Pazzagli L. Characterization of the major allergens purified from the venom of the paper wasp Polistes gallicus. Biochim Biophys Acta. 2003 Oct 13;1623(2-3):72-81.
6. Fiorillo C, Ponziani V, Giannini L, Cecchi C, Celli A, Nediani C, Perna AM, Liguori P, Nassi N, Formigli L, Tani A, Nassi P. Beneficial effects of poly (ADP-ribose) polymerase inhibition against the reperfusion injury in heart transplantation. Free Radic Res. 2003 Mar;37(3):331-9.
7. Chiarugi P, Taddei ML, Schiavone N, Papucci L, Giannoni E, Fiaschi T, Capaccioli S, Raugei G, Ramponi G. LMW-PTP is a positive regulator of tumor onset and growth. Oncogene. 2004 May 13;23(22):3905-14.
8. Malentacchi F, Marzocchini R, Gelmini S, Orlando C, Serio M, Ramponi G, Raugei G. Up-regulated expression of low molecular weight protein tyrosine phosphatases in different human cancers. Biochem Biophys Res Commun. 2005 Sep 2;334(3):875-83.
9. Donati C, Meacci E, Nuti F, Becciolini L, Farnararo M, Bruni P. Sphingosine 1-phosphate regulates myogenic differentiation: a major role for S1P2 receptor. FASEB J. 2005 Mar;19(3):449-51. Epub 2004 Dec 29.
10. Catarzi S, Biagioni C, Giannoni E, Favilli F, Marcucci T, Iantomasi T, Vincenzini MT. Redox regulation of platelet-derived-growth-factor-receptor: role of NADPH-oxidase and c-Src tyrosine kinase. Biochim Biophys Acta. 2005 Sep 10;1745(2):166-75. Epub 2005 Mar 22.
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DOTTORATI DI RICERCA |
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| Componente U.O. |
Dottorato di Ricerca |
Coordinatore |
Sede |
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Paola Bruni
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Biochemistry and Applied Biology
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Massimo Stefani
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Department of Biochemical Sciences, University of
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Guido Camici
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Biochemistry and Applied Biology
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Massimo Stefani
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Department of Biochemical Sciences, University of
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Gianni Cappugi
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Biochemistry and Applied Biology
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Massimo Stefani
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Department of Biochemical Sciences, University of
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Paola Chiarugi
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Biochemistry and Applied Biology
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Massimo Stefani
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Department of Biochemical Sciences, University of
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Fabrizio Chiti
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Biochemistry and Applied Biology
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Massimo Stefani
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Department of Biochemical Sciences, University of
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Paolo Cirri
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Biochemistry and Applied Biology
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Massimo Stefani
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Dipartimento di Scienze Biochimiche
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Giampaolo Manao
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Biochemistry and Applied Biology
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Massimo Stefani
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Dipartimento di Scienze Biochimiche
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Paolo Antonio Nassi
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Clinical and Preventive Pediatry
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Paolo Antonio Nassi
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Department of Pediatry, University of Florence
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Luigia Pazzagli
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Biochemistry and Applied Biology
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Massimo Stefani
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Department of Biochemical Sciences, University of
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Giovanni Raugei
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Biochemistry and Applied Biology
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Massimo Stefani
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Department of Biochemical Sciences, University of
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Niccolò Taddei
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Biochemistry and Applied Biology
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Massimo Stefani
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Department of Biochemical Sciences, University of
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Cristina Treves
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Clinical and Preventive Pediatry
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Paolo Antonio Nassi
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Department of Pediatry, University of Florence
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Vincenzini Maria Teresa
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Biochemistry and Applied Biology
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Massimo Stefani
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Department of Biochemical Sciences, University of
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CONGRESSI C.I.B. |
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| Congressi |
Partecipazione |
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CNB4
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CNB5
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CNB6
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CNB7
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CNB8
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| CNB10 |
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Consorzio (sedi e unità operative) 